Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Implication of free radical mechanisms in ethanol-induced cellular injury

1992 • 614 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

1996 • 278 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators

1994 • 202 citations

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics

1994 • 167 citations

In vivo formation of a free radical metabolite of ethanol.

1990 • 164 citations

Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols

1991 • 146 citations

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

1995 • 146 citations

Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

1997 • 143 citations

A simple test for predisposition to LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification.

1991 • 135 citations

Spin trapping of free radical species produced during the microsomal metabolism of ethanol

1988 • 131 citations

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population

1993 • 129 citations

Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake.

1994 • 124 citations

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

1993 • 117 citations

Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis

1995 • 116 citations

Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics

1996 • 113 citations

Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers.

1993 • 100 citations

Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol

1997 • 89 citations

Decrease in Cytochrome P4502E1 as Assessed by the Rate of Chlorzoxazone Hydroxylation in Alcoholics during the Withdrawal Phase

1995 • 80 citations

Human liver microsomal cytochrome P-450IIE1. Imnunological evaluation of its contribution to microsomal ethanol oxidation, carboti tetrachloride reduction and NADPH oxidase activity

1989 • 71 citations

Food Nutrition and Chemical Toxicity

1992 • 71 citations

Cytochromes P4502E1 and P4501A1 Genotypes and Susceptibility to Cirrhosis or Upper Aerodigestive Tract Cancer in Alcoholic Caucasians

1996 • 70 citations

[12] Chlorzoxazone: An in vitro and in vivo substrate probe for liver CYP2E1

1996 • 66 citations

Comparison of Levels of Cytochromes P‐450, CYP1A2, CYP2E1, and Their Related Monooxygenase Activities in Human Surgical Liver Samples

1993 • 65 citations

The Alcohol-altered Liver Membrane Antibody and Hepatitis C Virus Infection in the Progression of Alcoholic Liver Disease

1993 • 65 citations

High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans

1993 • 64 citations

Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxyIation of chlorzoxazone

1994 • 51 citations

Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease

1997 • 44 citations

[11] Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance

1994 • 27 citations

[24] Genetic polymorphism of human cytochrome P450 2E1

1996 • 20 citations