Decrease in Cytochrome P4502E1 as Assessed by the Rate of Chlorzoxazone Hydroxylation in Alcoholics during the Withdrawal Phase

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1991 • 1,173 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Carbohydrate-Deficient Transferrin in Serum: a New Marker of Potentially Harmful Alcohol Consumption Reviewed

1991 • 667 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

1989 • 320 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

1977 • 261 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity

1992 • 221 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

1993 • 216 citations

The induction of a specific form of cytochrome P-450 (P-450j) by fasting

1987 • 212 citations

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics

1994 • 167 citations

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

1993 • 156 citations

Induction of cytochrome P450IIE1 in the obese overfed rat.

1991 • 143 citations

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

1989 • 131 citations

Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1

1993 • 125 citations

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

1993 • 117 citations

Induction of Cytochrome P450 2E1 during Chronic Ethanol Exposure Occurs via Transcription of the Cyp 2E1 Gene When Blood Alcohol Concentrations Are High

1993 • 107 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA,

1993 • 94 citations

Evaluation of Carbohydrate‐deficient Transferrin Compared with Tf Index and Other Markers of Alcohol Abuse

1989 • 67 citations

Comparison of Levels of Cytochromes P‐450, CYP1A2, CYP2E1, and Their Related Monooxygenase Activities in Human Surgical Liver Samples

1993 • 65 citations

High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans

1993 • 64 citations

Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content.

1992 • 57 citations

Differences in the duration of the enhancement of liver mixed-function oxidase activities in ethanol-fed rats after withdrawal

1985 • 40 citations

Positive Correlation between Cytochrome P450 2E1 mRNA Level and Serum Estradiol Level in Human Uterine Endometrium

1994 • 10 citations