Epigenetics: Regulation Through Repression

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Nested Retrotransposons in the Intergenic Regions of the Maize Genome

1996 • 1,392 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

A viral suppressor of gene silencing in plants

1998 • 897 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

A Counterdefensive Strategy of Plant Viruses

1998 • 815 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1999 • 806 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

Maintenance of genomic methylation requires a SWI2/SNF2-like protein

1999 • 689 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Ploidy Regulation of Gene Expression

1999 • 646 citations

DNA methylation and chromatin modification

1999 • 641 citations

RNAi in C. elegans : Soaking in the Genome Sequence

1998 • 635 citations

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

1998 • 591 citations

Genetic instability of plant tissue cultures: breakdown of normal controls.

1994 • 588 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

Transgene‐induced gene silencing in plants

1998 • 490 citations

Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid

1998 • 460 citations

Plant Paralog to Viral Movement Protein That Potentiates Transport of mRNA into the Phloem

1999 • 459 citations

X-Chromosome inactivation: a repeat hypothesis

1998 • 455 citations

Demethylation-Induced Developmental Pleiotropy in Arabidopsis

1996 • 450 citations

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized

1999 • 419 citations

Developmental abnormalities and epimutations associated with DNA hypomethylation mutations.

1996 • 371 citations

The somatic replication of DNA methylation

1981 • 368 citations

Listening to the silent genes: transgene silencing, gene regulation and pathogen control

1999 • 367 citations

The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis

1998 • 360 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Polycombing the Genome: PcG, trxG, and Chromatin Silencing

1998 • 352 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

DNA modification of a maize transposable element correlates with loss of activity.

1986 • 331 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Creation of genomic methylation patterns

1996 • 313 citations

Isolation of quelling-defective ( qde ) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa

1997 • 307 citations

Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity

1996 • 286 citations

Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis

1993 • 283 citations

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1998 • 274 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance

1993 • 262 citations

Chromosomal Inheritance of Epigenetic States in Fission Yeast During Mitosis and Meiosis

1996 • 258 citations

Isolation of an RNA-Directed RNA Polymerase–Specific cDNA Clone from Tomato

1998 • 251 citations

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

1997 • 250 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent

1997 • 245 citations

RNAi and double-strand RNA

1999 • 242 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

Homologous Association of Oppositely Imprinted Chromosomal Domains

1996 • 238 citations

Arabidopsis Mutants Impaired in Cosuppression

1998 • 238 citations

Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome

1997 • 237 citations

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression

1998 • 235 citations

Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism

1999 • 235 citations

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

1999 • 228 citations

DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

1990 • 227 citations

The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse

1996 • 227 citations

RNA and the Epigenetic Regulation of X Chromosome Inactivation

1998 • 227 citations

An RNA-Based Information Superhighway in Plants

1998 • 225 citations

A Novel Imprinted Gene, Encoding a RING Zinc-Finger Protein, and Overlapping Antisense Transcript in the Prader-Willi Syndrome Critical Region

1999 • 225 citations

Taming of transposable elements by homology-dependent gene silencing

1999 • 221 citations

Transcriptional and Posttranscriptional Plant Gene Silencing in Response to a Pathogen

1998 • 217 citations

Dependence of Enhancer-Mediated Transcription of the Immunoglobulin μ Gene on Nuclear Matrix Attachment Regions

1994 • 216 citations

A model for RNA-mediated gene silencing in higher plants.

1998 • 213 citations

A DNA Methyltransferase Homolog With a Chromodomain Exists in Multiple Polymorphic Forms in Arabidopsis

1998 • 207 citations

Sources and Frequency of Somaclonal Variation

1994 • 207 citations

Altered DNA methylation and genome instability: A new pathway to cancer?

1997 • 204 citations

Mechanisms of genomic imprinting

1999 • 203 citations

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.

1991 • 195 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1997 • 189 citations

An Inverted Repeat Triggers Cytosine Methylation of Identical Sequences in Arabidopsis

1999 • 187 citations

Methylation analysis of CGG sites in the CpG island of the human FMR1 gene

1992 • 183 citations

Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion?

1997 • 180 citations

Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation

1999 • 178 citations

Infection of Tobacco orArabidopsisPlants by CMV Counteracts Systemic Post-transcriptional Silencing of Nonviral (Trans)Genes

1998 • 178 citations

A change of ploidy can modify epigenetic silencing.

1996 • 169 citations

The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?

1998 • 165 citations

Transgene Repeat Arrays Interact With Distant Heterochromatin and Cause Silencing in cis and trans

1997 • 159 citations

Gene Silencing

1999 • 157 citations

Plant transposable elements and the genome

1994 • 153 citations

Rapid structural and epigenetic changes in polyploid and aneuploid genomes

1999 • 151 citations

Nonmethylated Transposable Elements and Methylated Genes in a Chordate Genome

1999 • 151 citations

Homologous chromosome pairing in wheat

1999 • 149 citations

Position-Dependent Methylation and Transcriptional Silencing of Transgenes in Inverted T-DNA Repeats: Implications for Posttranscriptional Silencing of Homologous Host Genes in Plants

1998 • 143 citations

Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin

1998 • 139 citations

Paramutation and transgene silencing: a common response to invasive DNA?

1996 • 139 citations

Paramutation and related allelic interactions

1997 • 135 citations

Interchromosomal Transfer of Epigenetic States in Ascobolus: Transfer of DNA Methylation Is Mechanistically Related to Homologous Recombination

1996 • 132 citations

Transvection and other homology effects

1999 • 131 citations

Genomic Imprinting and Cancer

2006 • 128 citations

High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome

1993 • 126 citations

Inactive chromatin spreads from a focus of methylation.

1993 • 124 citations

Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis

1997 • 121 citations

Epigenetic Variation Illustrated by DNA Methylation Patterns of the Fragile-X Gene FMR1

1997 • 120 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

Molecular and cytogenetic characterization of a transgene locus that induces silencing and methylation of homologous promoters intrans

1999 • 109 citations

Host cis -Mediated Extinction of a Retrovirus Permissive for Expression in Embryonal Stem Cells during Differentiation

1998 • 105 citations

Paramutation of the r1 Locus of Maize Is Associated With Increased Cytosine Methylation

1998 • 97 citations

Activation of systemic acquired silencing by localised introduction of DNA

1999 • 96 citations

Paramutation and Chromosome Organization

1960 • 95 citations

Transcription complex disruption caused by a transition in chromatin structure.

1991 • 95 citations

Association of homologous chromosomes during floral development

1997 • 92 citations

Epigenetic phenomena: Epigenetic phenomena: Paramutation and gene silencing in plants

1996 • 91 citations

Methylation of the viral genome in an in vitro model of herpes simplex virus latency.

1982 • 88 citations

Somaclonal Variation: The Myth of Clonal Uniformity

1985 • 87 citations

Trans-Sensing Effects: The Ups and Downs of Being Together

1998 • 83 citations

Host-Cell-Determined Methylation of Specific Epstein-Barr Virus Promoters Regulates the Choice between Distinct Viral Latency Programs

1997 • 81 citations

Homologous association of the Bithorax-Complex during embryogenesis: consequences for transvection in Drosophila melanogaster

1998 • 80 citations

The trithorax-group and Polycomb-group chromatin modifiers: implications for disease

1999 • 79 citations

The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

1998 • 78 citations

Genetics: A touch of elegance with RNAi

1999 • 75 citations

The Mystique of Epigenetics

1998 • 74 citations

Polyploidy and transposons

1998 • 74 citations

Methylation of replicating and post-replicated mouse L-cell DNA.

1983 • 70 citations

Core promoter elements can regulate transcription on a separate chromosome in trans

1999 • 67 citations

The role of Xist in X-inactivation

1998 • 66 citations

Genomic Imprinting in Plants

1999 • 65 citations

Gene Silencing in Higher Plants and Related Phenomena in Other Eukaryotes

1995 • 55 citations

Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila

1998 • 53 citations

Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes

1998 • 51 citations

Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment

1998 • 47 citations

Chromosomal imprinting in plants

1998 • 45 citations

Parental nucleosomes segregated to newly replicated chromatin are underacetylated relative to those assembled de novo

1993 • 45 citations

MIP: An Epigenetic Gene Silencing Process in Ascobolus immersus

1995 • 45 citations

Chromatin Silencing and Arabidopsis Development: A Role for Polycomb Proteins

1999 • 43 citations

Do unintended antisense transcripts contribute to sense cosuppression in plants?

1999 • 32 citations

Enhanced transcription factor access to arrays of histone H3/H4 tetramer⋅DNA complexes in vitro : Implications for replication and transcription

1998 • 31 citations

Intercellular Connections Are Developmentally Controlled to Help Move Molecules through the Plant

1999 • 28 citations

Phloem transport: Are you chaperoned?

1999 • 23 citations

Signalling in gene silencing

1999 • 22 citations

Inhibition of Human T Cell Leukaemia Virus Type I Long Terminal Repeat Expression by DNA Methylation: Implications for Latency

1994 • 18 citations

Structure prediction: Folding proteins by pattern recognition

1997 • 18 citations

Effect of hexamethylene bisacetamide and cyclosporin A on recovery of herpes simplex virus type 2 from the in vitro model of latency in a human neuroblastoma cell line.

1990 • 12 citations

Evolution of the X chromosome

1990 • 11 citations

Resistance to Methylation de novo of the Human Cytomegalovirus Immediate Early Enhancer in a Model for Virus Latency and Reactivation in vitro

1987 • 10 citations

Too much latitude for Rapoport's rule?

1998 • 9 citations