The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

CpG Islands in vertebrate genomes

1987 • 3,315 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

The essentials of DNA methylation

1992 • 960 citations

Effects of DNA methylation on DNA-binding proteins and gene expression

1993 • 732 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state

1994 • 499 citations

Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts

1992 • 493 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein.

1994 • 447 citations

Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.

1993 • 368 citations

Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes

1992 • 360 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1995 • 220 citations

Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells

1996 • 192 citations

Epstein-Barr virus small nuclear RNAs are not expressed in permissively infected cells in AIDS-associated leukoplakia.

1990 • 184 citations

Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma

1992 • 183 citations

Epstein-Barr Virus (EBV) in Endemic Burkitt's Lymphoma: Molecular Analysis of Primary Tumor Tissue

1998 • 176 citations

Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA

1990 • 164 citations

Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease

1996 • 162 citations

Persistence of the Entire Epstein-Barr Virus Genome Integrated into Human Lymphocyte DNA

1984 • 156 citations

Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.

1991 • 153 citations

Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines.

1995 • 150 citations

5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael

1989 • 149 citations

Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein

1996 • 144 citations

The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated

1992 • 129 citations

Transcriptional Activation of the Epstein-Barr Virus Latency C Promoter after 5-Azacytidine Treatment: Evidence that Demethylation at a Single CpG Site Is Crucial

1995 • 125 citations

The Role of Methylation in the Phenotype-dependent Modulation of Epstein-Barr Nuclear Antigen 2 and Latent Membrane Protein Genes in Cells Latently Infected with Epstein-Barr Virus

1989 • 125 citations

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes.

1989 • 122 citations

Three transcriptionally distinct forms of epstein-barr virus latency in somatic cell hybrids: Cell phenotype dependence of virus promoter usage

1992 • 114 citations

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes.

1991 • 109 citations

Epstein-Barr virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas

1993 • 101 citations

Clonality, expression and methylation patterns of the Epstein-Barr virus genomes in lethal midline granulomas classified as peripheral angiocentric T cell lymphomas

1994 • 88 citations

Host-Cell-Determined Methylation of Specific Epstein-Barr Virus Promoters Regulates the Choice between Distinct Viral Latency Programs

1997 • 81 citations

The Epstein-Barr virus (EBV) nuclear antigen 1 BamHI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle

1992 • 77 citations

CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease

1996 • 76 citations

Constitutive Activation of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Gene Transcription by IRF1 and IRF2 during Restricted EBV Latency

1997 • 73 citations

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication

1993 • 70 citations

Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma

1997 • 69 citations

Transcriptional Initiation Is Controlled by Upstream GC-Box Interactions in a TATAA-Less Promoter

1990 • 61 citations

Transcription of the Epstein-Barr virus gene EBNA-1 from different promoters in nasopharyngeal carcinoma and B-lymphoblastoid cells

1992 • 60 citations

Host cell phenotype-dependent methylation patterns of Epstein--Barr virus DNA

1991 • 60 citations

Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virus BamHI W promoter in Burkitt lymphoma lines

1992 • 59 citations

Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes

1997 • 59 citations

Reciprocal regulation of the Epstein-Barr virus BamHI-F promoter by EBNA-1 and an E2F transcription factor.

1994 • 59 citations

Sequence-Specific Methylation Inhibits the Activity of the Epstein-Barr Virus LMP 1 and BCR2 Enhancer-Promoter Regions

1994 • 52 citations

Host-cell-phenotype-dependent control of the BCR2/BWR1 promoter complex regulates the expression of Epstein-Barr virus nuclear antigens 2-6.

1992 • 51 citations

The Epstein-Barr virus BamHI F promoter is an early lytic promoter: lack of correlation with EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines

1995 • 50 citations

Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter

1997 • 49 citations

Identification of a Novel Promoter Located Within theBamHI Q Region of the Epstein-Barr Virus Genome for the EBNA 1 Gene

1995 • 48 citations

RNA polymerase III-transcribed EBER 1 and 2 transcription units are expressed and hypomethylated in the major Epstein-Barr virus-carrying cell types

1992 • 43 citations

Transcription of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene occurs before induction of the BCR2 (Cp) EBNA gene promoter during the initial stages of infection in B cells

1996 • 39 citations

The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element

1997 • 33 citations

B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1

1997 • 32 citations

Characterization of the Epstein-Barr virus Fp promoter

1995 • 28 citations

Reciprocal Regulation of the Epstein-Barr Virus BamHI-F Promoter by EBNA-1 and an E2F Transcription Factor

1994 • 26 citations

Host factors LR1 and Sp1 regulate the Fp promoter of Epstein-Barr virus.

1995 • 23 citations

Regulation of Epstein-Barr Virus BamHI-H Divergent Promoter by DNA Methylation

1993 • 19 citations

A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with type I and II latency from those arising during induction of the viral lytic cycle

1996 • 17 citations

Epstein-Barr virus (EBV) gene expression in lymphoid B cells during acute infectious mononucleosis (IM) and clonality of the directly growing cell lines

1997 • 10 citations

Dual EBNA1 promoter usage by Epstein-Barr virus in human B-cell lines expressing unique intermediate cellular phenotypes

1994 • 8 citations

Deleted Work

1955 • 0 citations