The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

Effects of DNA methylation on DNA-binding proteins and gene expression

1993 • 732 citations

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

1993 • 584 citations

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

1992 • 502 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

DNA Methylation Specifies Chromosomal Localization of MeCP2

1996 • 343 citations

Capturing genes encoding membrane and secreted proteins important for mouse development.

1995 • 321 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Storage of Two-Cell Mouse Embryos in Vitro

1969 • 314 citations

Removal of repeated sequences from hybridisation probes

1985 • 293 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

5-Methylcytosine localised in mammalian constitutive heterochromatin

1974 • 267 citations

A simple method for subcloning DNA fragments from gel slices

1990 • 221 citations

Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

1982 • 184 citations

Anin situtransgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis

1989 • 148 citations

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

1983 • 98 citations

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

1990 • 67 citations

Genetic and Physical Mapping of a Gene Encoding a Methyl CpG Binding Protein, Mecp2, to the Mouse X Chromosome

1994 • 56 citations

Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off.

1991 • 34 citations

A rapid and efficient method for freezing and recovering clones of embryonic stem cells

1992 • 25 citations