Inhibition of Human T Cell Leukaemia Virus Type I Long Terminal Repeat Expression by DNA Methylation: Implications for Latency

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

DNA methylation and gene activity

1988 • 904 citations

Cationic liposome-mediated RNA transfection.

1989 • 804 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

DNA methylation patterns Formation and function

1984 • 312 citations

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

1985 • 283 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

1993 • 258 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Firefly luciferase luminescence assays using scintillation counters for quantitation in transfected mammalian cells

1988 • 199 citations

Infectivity and methylation of retroviral genomes is correlated with expression in the animal

1981 • 165 citations

Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia.

1984 • 162 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency.

1990 • 150 citations

Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection

1984 • 99 citations

Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression.

1987 • 69 citations

Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.

1992 • 63 citations

Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells

1980 • 57 citations

Human T-lymphotropic virus type I transcriptional regulation by methylation.

1990 • 39 citations

Adult T Cell Leukemia/Lymphoma

1991 • 33 citations

Transcriptional block of HTLV-I LTR by sequence-specific methylation

1991 • 32 citations

Methylation pattern of human T‐cell leukemia virus in vivo and in vitro: pX and LTR regions are hypomethylated in vivo

1985 • 25 citations

Quantitation of transient gene expression after electroporation

1992 • 22 citations

Transcription inhibition of SV40 by in vitro DNA methylation

1990 • 9 citations