Transgene‐induced gene silencing in plants

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

Epigenetic mechanisms of gene regulation

1996 • 1,097 citations

Initiation and Maintenance of Virus-Induced Gene Silencing

1998 • 972 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

1990 • 962 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

Arabidopsis thaliana DNA Methylation Mutants

1993 • 674 citations

Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants

1989 • 544 citations

Review Article: The Silence of Genes in Transgenic Plants

1997 • 455 citations

Plants combat infection by gene silencing

1997 • 384 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.

1996 • 375 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

Repeat-induced G-C to A-T Mutations in Neurospora

1989 • 353 citations

Non-Mendelian Mutation Allowing Ureidosuccinic Acid Uptake in Yeast

1971 • 316 citations

RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia

1997 • 308 citations

Isolation of quelling-defective ( qde ) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa

1997 • 307 citations

Suppression of beta-1,3-glucanase transgene expression in homozygous plants.

1992 • 303 citations

Transgene‐mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover

1994 • 297 citations

Expression of single copies of a strongly expressed 35S transgene can be silenced post‐transcriptionally

1996 • 291 citations

Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity

1996 • 286 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

RNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants

1996 • 284 citations

Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis

1993 • 283 citations

A GENETIC CHANGE ASSOCIATED WITH THE R LOCUS IN MAIZE WHICH IS DIRECTED AND POTENTIALLY REVERSIBLE

1956 • 280 citations

Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants

1990 • 280 citations

Endogenous and environmental factors influence 35S promoter methylation of a maize A1 gene construct in transgenic petunia and its colour phenotype

1992 • 271 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance

1993 • 262 citations

Position-effect variegation and the new biology of heterochromatin

1994 • 244 citations

Cosuppression, Flower Color Patterns, and Metastable Gene Expression States

1995 • 243 citations

Post-transcriptional gene silencing in plants

1997 • 241 citations

Arabidopsis Mutants Impaired in Cosuppression

1998 • 238 citations

Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes

1994 • 233 citations

Differences in DNA‐methylation are associated with a paramutation phenomenon in transgenic petunia

1993 • 219 citations

Transgene and gene suppression: telling us something new?

1995 • 218 citations

Transcriptional and Posttranscriptional Plant Gene Silencing in Response to a Pathogen

1998 • 217 citations

A model for RNA-mediated gene silencing in higher plants.

1998 • 213 citations

The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

1997 • 196 citations

Distinct phenotypes generated by overexpression and suppression of S-adenosyl-L-methionine synthetase reveal developmental patterns of gene silencing in tobacco.

1994 • 191 citations

RNA-Mediated Virus Resistance in Transgenic Plants: Exploitation of a Cellular Pathway Possibly Involved in RNA Degradation

1994 • 186 citations

Identification of plant genetic loci involved in a posttranscriptional mechanism for meiotically reversible transgene silencing.

1994 • 184 citations

Post‐transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats

1997 • 180 citations

Infection of Tobacco orArabidopsisPlants by CMV Counteracts Systemic Post-transcriptional Silencing of Nonviral (Trans)Genes

1998 • 178 citations

Regulated inactivation of homologous gene expression in transgenic Nicotiana sylvestris plants containing a defense-related tobacco chitinase gene

1992 • 164 citations

The methylation patterns of chromosomal integration regions influence gene activity of transferred DNA in Petunia hybrida

1992 • 161 citations

Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis

1998 • 157 citations

Gene inactivation triggered by recognition between DNA repeats

1994 • 144 citations

Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

1992 • 141 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes

1996 • 128 citations

RIGS (repeat-induced gene silencing) in Arabidopsis is transcriptional and alters chromatin configuration.

1996 • 126 citations

Epigenetic variants of a transgenic petunia line show hypermethylation in transgene DNA: an indication for specific recognition of foreign DNA in transgenic plants

1994 • 121 citations

Transgenes are dispensable for the RNA degradation step of cosuppression

1998 • 120 citations

Identification of a general silencer for 19S and 35S promoters in a transgenic tobacco plant : 90 bp of homology in the promoter sequence are sufficient for trans-inactivation

1993 • 117 citations

Frequencies, Timing, and Spatial Patterns of Co-Suppression of Nitrate Reductase and Nitrite Reductase in Transgenic Tobacco Plants

1996 • 110 citations

Co-suppression of nitrate reductase host genes and transgenes in transgenic tobacco plants

1994 • 107 citations

A Transcriptionally Active State Is Required for Post-Transcriptional Silencing (Cosuppression) of Nitrate Reductase Host Genes and Transgenes.

1997 • 89 citations

The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence

1997 • 83 citations

Transgene inactivation inPetunia hybrida is influenced by the properties of the foreign gene

1995 • 82 citations

Cytosine methylation at CG and CNG sites is not a prerequisite for the initiation of transcriptional gene silencing in plants, but it is required for its maintenance

1998 • 71 citations

Condensation of chromatin in transcriptional regions of an inactivated plant transgene: evidence for an active role of transcription in gene silencing

1997 • 63 citations

Do transgene arrays form heterochromatin in vertebrates?

1997 • 58 citations

Sequence homology requirements for transcriptional silencing of 35S transgenes and post-transcriptional silencing of nitrite reductase (trans)genes by the tobacco 271 locus

1996 • 45 citations

Promoter-dependent trans-inactivation in transgenic tobacco plants : kinetic aspects of gene silencing and gene reactivation

1994 • 45 citations

Silencing of a beta-1,3-glucanase transgene is overcome during seed formation.

1997 • 29 citations

Gene inactivation in Arabidopsis thaliana is not accompanied by an accumulation of repeat-induced point mutations

1994 • 21 citations

Efficient DNA pairing in a Neurospora mutant defective in chromosome pairing

1991 • 20 citations

Nitrite reductase silencing as a tool for selecting spontaneous haploid plants

1995 • 5 citations

Deleted Work

1955 • 0 citations