DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

Evolution by Gene Duplication

1970 • 6,000 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

DNA methylation and gene activity

1988 • 904 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Zinc fingers: Gilt by association

1988 • 799 citations

Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants

1989 • 544 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

Evolution by Gene Duplication

1971 • 443 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolution

1981 • 373 citations

Of urfs and orfs : a primer on how to analyze devised amino acid sequences

1986 • 370 citations

Rearrangement of duplicated DNA in specialized cells of Neurospora

1987 • 366 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

McrA and McrB restriction phenotypes of someE.colistrains and implications for gene cloning

1988 • 337 citations

Hen's Teeth and Horse's Toes

1983 • 309 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

Structure of the Drosophila DNA topoisomerase II gene

1989 • 153 citations

MEIOTIC RECOMBINATION BETWEEN DUPLICATED GENETIC ELEMENTS IN SACCHAROMYCES CEREVISIAE

1985 • 106 citations

Type II restriction—modification systems

1988 • 77 citations

Memories of mother and father

1987 • 73 citations

Biochemical characterization of topoisomerase I purified from avian erythrocytes

1983 • 70 citations

Fingering too many proteins

1988 • 61 citations

Methylated bases in mycoplasmal DNA

1980 • 59 citations

The zinc finger region of simian virus 40 large T antigen

1989 • 57 citations

Two-dimensional DNA electrophoresis applied to the study of DNA methylation and the analysis of genome size in Myxococcus xanthus

1982 • 54 citations

Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells.

1985 • 51 citations

DNA methylation in wheat

1987 • 42 citations