Resistance to Methylation de novo of the Human Cytomegalovirus Immediate Early Enhancer in a Model for Virus Latency and Reactivation in vitro

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

1964 • 2,108 citations

A simple method for DNA restriction site mapping

1976 • 1,025 citations

5-Methylcytosine in Eukaryotic DNA

1981 • 744 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Transcriptionally active chromatin

1984 • 361 citations

Negative regulation of viral enhancers in undifferentiated embryonic stem cells

1985 • 347 citations

Structural analysis of the major immediate early gene of human cytomegalovirus

1984 • 342 citations

Temporal Patterns of Human Cytomegalovirus Transcription: Mapping the Viral RNAs Synthesized at Immediate Early, Early, and Late Times After Infection

1982 • 311 citations

Normal rat cell lines deficient in nuclear thymidine kinase

1981 • 307 citations

Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.

1984 • 296 citations

Organization and expression of the immediate early genes of human cytomegalovirus

1983 • 288 citations

Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1

1985 • 270 citations

Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components

1985 • 245 citations

DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.

1981 • 231 citations

Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169

1983 • 199 citations

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity

1985 • 199 citations

Cytomegalovirus Replicates in Differentiated But Not in Undifferentiated Human Embryonal Carcinoma Cells

1984 • 196 citations

DNA Methylation--A Regulatory Signal in Eukaryotic Gene Expression

1981 • 192 citations

Eukaryotic DNA methylation

1983 • 192 citations

Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression

1983 • 187 citations

Human cytomegalovirus DNA: Restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs

1981 • 171 citations

The structure of the major immediate early gene of human cytomegalovirus strain AD169

1985 • 170 citations

Latent Infection and the Elusive Cytomegalovirus

1983 • 161 citations

Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection

1981 • 159 citations

Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.

1985 • 145 citations

Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes

1985 • 145 citations

Predominant immediate-early transcripts of human cytomegalovirus AD 169

1984 • 137 citations

Monoclonal antibodies to cytomegalovirus: rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia

1982 • 134 citations

Chromatin Structure and de Novo Methylation of Sperm DNA: Implications for Activation of the Paternal Genome

1985 • 119 citations

Autoregulation of the human cytomegalovirus major immediate-early gene

1985 • 107 citations

Methylation, expression and chromosomal position of genes in mammals

1984 • 100 citations

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

1983 • 98 citations

5-methylcytosine is localized in nucleosomes that contain histone H1.

1983 • 97 citations

Constitutive and retinoic acid-inducible expression of cytomegalovirus immediate-early genes in human teratocarcinoma cells

1986 • 91 citations

Methylation of the viral genome in an in vitro model of herpes simplex virus latency.

1982 • 88 citations

The effect of site specific methylation on restriction endonuclease digestion

1985 • 84 citations

Immediate early antigens in human cytomegalovirus infected cells

1977 • 76 citations

Alteration of apparent restriction endonuclease recognition specificities by DNA methylases

1984 • 75 citations

Immunoprecipitation of virus-specific immediate-early and early polypeptides from cells lytically infected with human cytomegalovirus strain AD 169

1981 • 72 citations

Hhalmethylase and restriction endonuclease as probes for B to Z DNA conformational changes in d(GCGC) sequences

1984 • 71 citations

Primary DNA Sequence Determines Sites of Maintenance and De Novo Methylation by Mammalian DNA Methyltransferases

1986 • 65 citations

Chromosomal Position and Specific Demethylation in Enhancer Sequences of Germ Line-Transmitted Retroviral Genomes During Mouse Development

1985 • 60 citations

Immediate-early proteins of human cytomegalovirus strains AD169, Davis, and towne differ in electrophoretic mobility

1981 • 52 citations

Evidence for Early Nuclear Antigens in Cytomegalovirus-Infected Cells

1976 • 47 citations

Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate-early gene products by protein synthesis inhibition

1986 • 45 citations

Human cytomegalovirus-induced immediate early antigens: analysis in sodium dodecyl sulfate-polyacrylamide gel electrophoresis after immunoprecipitation

1979 • 42 citations

DNA methylation: sequences flanking C-G pairs modulate the specificity of the human DNA methylase

1985 • 40 citations

Cytomegalovirus Infection of Human Teratocarcinoma Cells in Culture

1985 • 39 citations

Cytomegalovirus and Immunity

1982 • 35 citations

Transcriptional Activation of the Major Immediate Early Transcription Unit of Human Cytomegalovirus by Heat-shock, Arsenite and Protein Synthesis Inhibitors

1987 • 29 citations

Human cytomegalovirus-induced chromatin factors responsible for changes in template activity and structure of infected cell chromatin

1978 • 29 citations

Induction of Pre‐Early Nuclear Antigen(s) in HEL Cells Infected with Human Cytomegalovirus

1979 • 26 citations

Comparison of the Immediate Early Polypeptides of Human Cytomegalovirus Isolates

1981 • 23 citations

Chromatin pattern consisting of repeating bipartite structures in WI-38 cells infected with human cytomegalovirus

1978 • 21 citations

Development of Early Nuclear Antigen in Cytomegalovirus Infected Cells in the Presence of RNA and Protein Synthesis Inhibitors

1978 • 19 citations