Biogenesis of small RNAs in animals

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Genome sequencing in microfabricated high-density picolitre reactors

2005 • 7,594 citations

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

2008 • 5,001 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

MicroRNA genes are transcribed by RNA polymerase II

2004 • 4,200 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

2007 • 3,587 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

2005 • 2,666 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS

2006 • 2,583 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

MicroRNA biogenesis: coordinated cropping and dicing

2005 • 2,443 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila

2007 • 2,410 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

Genetic and Functional Diversification of Small RNA Pathways in Plants

2004 • 1,553 citations

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

2008 • 1,544 citations

Intronic microRNA precursors that bypass Drosha processing

2007 • 1,542 citations

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

2005 • 1,527 citations

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

2006 • 1,510 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

Selective Blockade of MicroRNA Processing by Lin28

2008 • 1,422 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

2004 • 1,370 citations

miR2Disease: a manually curated database for microRNA deregulation in human disease

2008 • 1,367 citations

RNA polymerase III transcribes human microRNAs

2006 • 1,359 citations

MicroRNAs in Cancer

2008 • 1,339 citations

Widespread microRNA repression by Myc contributes to tumorigenesis

2007 • 1,300 citations

A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline

2006 • 1,277 citations

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

2004 • 1,254 citations

SMAD proteins control DROSHA-mediated microRNA maturation

2008 • 1,197 citations

A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila

2007 • 1,136 citations

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

2008 • 1,107 citations

Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

2005 • 1,106 citations

MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline

2007 • 1,094 citations

A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish

2007 • 1,089 citations

Methylation as a Crucial Step in Plant microRNA Biogenesis

2005 • 1,082 citations

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

2008 • 1,077 citations

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

2007 • 1,052 citations

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

2008 • 1,036 citations

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

2008 • 1,031 citations

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

2007 • 1,013 citations

The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila

2007 • 1,000 citations

Single Processing Center Models for Human Dicer and Bacterial RNase III

2004 • 985 citations

Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control

2007 • 970 citations

Human embryonic stem cells express a unique set of microRNAs

2004 • 960 citations

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal

1998 • 955 citations

The Small RNA Profile during Drosophila melanogaster Development

2003 • 955 citations

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

2008 • 930 citations

Structural Basis for Double-Stranded RNA Processing by Dicer

2006 • 925 citations

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

2008 • 876 citations

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

2001 • 853 citations

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

2008 • 849 citations

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

2006 • 835 citations

A novel class of small RNAs in mouse spermatogenic cells

2006 • 827 citations

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

2004 • 815 citations

Processing of intronic microRNAs

2007 • 810 citations

Functions of microRNAs and related small RNAs in plants

2006 • 805 citations

Mammalian Mirtron Genes

2007 • 782 citations

A Human snoRNA with MicroRNA-Like Functions

2008 • 779 citations

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

2008 • 774 citations

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

2005 • 753 citations

Muscle-specific microRNA miR-206 promotes muscle differentiation

2006 • 752 citations

An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing

2008 • 747 citations

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

2001 • 745 citations

Characterization of the piRNA Complex from Rat Testes

2006 • 728 citations

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

2008 • 726 citations

Computational identification of DrosophilamicroRNA genes

2003 • 724 citations

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

2004 • 717 citations

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals

2008 • 712 citations

RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila

2006 • 695 citations

Specialization and evolution of endogenous small RNA pathways

2007 • 694 citations

MicroRNA-directed transcriptional gene silencing in mammalian cells

2008 • 691 citations

Plant microRNA: A small regulatory molecule with big impact

2005 • 690 citations

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

2003 • 690 citations

Myogenic factors that regulate expression of muscle-specific microRNAs

2006 • 686 citations

An endogenous small interfering RNA pathway in Drosophila

2008 • 682 citations

The role of PACT in the RNA silencing pathway

2006 • 679 citations

A Hexanucleotide Element Directs MicroRNA Nuclear Import

2007 • 666 citations

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

2008 • 665 citations

TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

2005 • 650 citations

Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression

2007 • 643 citations

Elucidation of the Small RNA Component of the Transcriptome

2005 • 638 citations

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

2005 • 629 citations

Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

2008 • 629 citations

Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome

2006 • 618 citations

The dsRNA protein kinase PKR: Virus and cell control

2007 • 600 citations

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

2004 • 592 citations

A Protein Sensor for siRNA Asymmetry

2004 • 584 citations

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

2003 • 569 citations

The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster

2006 • 568 citations

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

2008 • 564 citations

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

2008 • 555 citations

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

2006 • 553 citations

piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells

2000 • 541 citations

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

2007 • 540 citations

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

2005 • 537 citations

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

2007 • 535 citations

Structure of the guide-strand-containing argonaute silencing complex

2008 • 521 citations

The Drosophila RNA Methyltransferase, DmHen1, Modifies Germline piRNAs and Single-Stranded siRNAs in RISC

2007 • 521 citations

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

2005 • 518 citations

Structural requirements for pre-microRNA binding and nuclear export by Exportin 5

2004 • 476 citations

Structure and conserved RNA binding of the PAZ domain

2003 • 468 citations

Post-transcriptional regulation of microRNA expression

2006 • 457 citations

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

2008 • 455 citations

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression

2008 • 445 citations

Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi- interacting RNAs at their 3′ ends

2007 • 444 citations

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

2005 • 421 citations

DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs

2007 • 417 citations

Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

2007 • 411 citations

In vitro reconstitution of the human RISC-loading complex

2008 • 410 citations

Posttranscriptional Crossregulation between Drosha and DGCR8

2009 • 409 citations

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

2005 • 406 citations

Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis

2008 • 400 citations

Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors

2007 • 397 citations

Slicer function of Drosophila Argonautes and its involvement in RISC formation

2005 • 389 citations

Cleavage of the siRNA passenger strand during RISC assembly in human cells

2006 • 386 citations

RNA editing of the microRNA‐151 precursor blocks cleavage by the Dicer–TRBP complex

2007 • 383 citations

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

2008 • 380 citations

Sorting of Drosophila Small Silencing RNAs

2007 • 370 citations

Primary microRNA transcripts are processed co-transcriptionally

2008 • 369 citations

Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster

2007 • 346 citations

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

2003 • 343 citations

Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

2004 • 342 citations

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

2008 • 334 citations

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

2008 • 329 citations

Drosophila PIWI associates with chromatin and interacts directly with HP1a

2007 • 328 citations

aubergineencodes aDrosophilapolar granule component required for pole cell formation and related to eIF2C

2001 • 321 citations

Frequency and fate of microRNA editing in human brain

2008 • 316 citations

Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila

2005 • 316 citations

zucchini and squash Encode Two Putative Nucleases Required for rasiRNA Production in the Drosophila Germline

2007 • 312 citations

Retracted: Post‐transcriptional regulation of the let‐7 microRNA during neural cell specification

2006 • 310 citations

Efficient Processing of Primary microRNA Hairpins by Drosha Requires Flanking Nonstructured RNA Sequences

2005 • 297 citations

The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis

2008 • 295 citations

Heme is involved in microRNA processing

2006 • 284 citations

Endogenous RNA Interference Provides a Somatic Defense against Drosophila Transposons

2008 • 279 citations

MicroRNA precursors in motion: exportin-5 mediates their nuclear export

2004 • 273 citations

Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs

2004 • 272 citations

Editor meets silencer: crosstalk between RNA editing and RNA interference

2006 • 272 citations

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing

2006 • 265 citations

Gene silencing mechanisms mediated by Aubergine–piRNA complexes in Drosophila male gonad

2007 • 263 citations

Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini

2007 • 262 citations

Plant and animal microRNAs: similarities and differences

2005 • 261 citations

Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA

2001 • 258 citations

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

2008 • 238 citations

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

2002 • 236 citations

Evidence for a piwi-Dependent RNA Silencing of the gypsy Endogenous Retrovirus by the Drosophila melanogaster flamenco Gene

2004 • 236 citations

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

2008 • 236 citations

Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing

2008 • 235 citations

Maelstrom, aDrosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage

2003 • 233 citations

Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

2001 • 230 citations

The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated

2007 • 224 citations

Human microRNA prediction through a probabilistic co-learning model of sequence and structure

2005 • 219 citations

Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline

2005 • 217 citations

let-7 regulates Dicer expression and constitutes a negative feedback loop

2008 • 215 citations

Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

2008 • 213 citations

Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA

2002 • 196 citations

Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing

2000 • 193 citations

Small RNAs: Regulators and guardians of the genome

2007 • 190 citations

Localization of the Developmental Timing Regulator Lin28 to mRNP Complexes, P-bodies and Stress Granules

2007 • 188 citations

Ribonuclease Dicer Cleaves Triplet Repeat Hairpins into Shorter Repeats that Silence Specific Targets

2007 • 185 citations

Characterization of endogenous human argonautes and their miRNA partners in RNA silencing

2008 • 181 citations

Sequence Relationships among C. elegans, D. melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology

2008 • 177 citations

Argonaute Loading Improves the 5′ Precision of Both MicroRNAs and Their miRNA∗ Strands in Flies

2008 • 172 citations

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

2003 • 164 citations

Exportin-5 Mediates Nuclear Export of Minihelix-containing RNAs

2003 • 164 citations

Regulatory Relationship among piwi, pumilio, and bag-of-marbles in Drosophila Germline Stem Cell Self-Renewal and Differentiation

2005 • 152 citations

RNAi‐directed assembly of heterochromatin in fission yeast

2005 • 148 citations

Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production

2008 • 147 citations

Exon Tethering in Transcription by RNA Polymerase II

2006 • 147 citations

MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans

2007 • 140 citations

A novel type of RNase III family proteins in eukaryotes

2000 • 138 citations

The RNA Interference Proteins and Vasa Locus are Involved in the Silencing of Retrotransposons in the Female Germline ofDrosophila melanogaster

2004 • 136 citations

Crystal structure of human DGCR8 core

2007 • 108 citations

Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins

2007 • 108 citations

Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans

2007 • 91 citations

Bioinformatic discovery of microRNA precursors from human ESTs and introns

2006 • 59 citations

Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location

2002 • 42 citations

Genomic defence with a slice of pi

2007 • 36 citations

Deleted Work

1955 • 0 citations