Ribonuclease Dicer Cleaves Triplet Repeat Hairpins into Shorter Repeats that Silence Specific Targets

MicroRNAs

2004 • 33,206 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9

2001 • 1,191 citations

Single Processing Center Models for Human Dicer and Bacterial RNase III

2004 • 985 citations

Recruitment of human muscleblind proteins to (CUG)n expansions associated with myotonic dystrophy

2000 • 880 citations

RNAi-mediated pathways in the nucleus

2005 • 839 citations

Post-transcriptional gene silencing by double-stranded RNA

2001 • 833 citations

Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles

2005 • 791 citations

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

2002 • 622 citations

Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues.

1995 • 576 citations

Sequence requirements for micro RNA processing and function in human cells

2003 • 538 citations

RNAi: The Nuts and Bolts of the RISC Machine

2005 • 474 citations

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR

2000 • 240 citations

RNA structure of trinucleotide repeats associated with human neurological diseases

2003 • 210 citations

Structural Features of MicroRNA (miRNA) Precursors and Their Relevance to miRNA Biogenesis and Small Interfering RNA/Short Hairpin RNA Design

2004 • 183 citations

RNA pathogenesis of the myotonic dystrophies

2004 • 182 citations

CUG Repeats Present in Myotonin Kinase RNA Form Metastable “Slippery” Hairpins

1997 • 162 citations

Molecular medicine for the brain: silencing of disease genes with RNA interference

2004 • 126 citations

CAG Repeats Containing CAA Interruptions Form Branched Hairpin Structures in Spinocerebellar Ataxia Type 2 Transcripts

2004 • 122 citations

The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer

2003 • 119 citations

Cytoplasmic and Nuclear Retained DMPK mRNAs Are Targets for RNA Interference in Myotonic Dystrophy Cells

2005 • 110 citations

Dynamic mutation: possible mechanisms and significance in human disease

1997 • 97 citations

Facile FMR1 mRNA structure regulation by interruptions in CGG repeats

2005 • 88 citations

Molecular Architecture of CAG Repeats in Human Disease Related Transcripts

2004 • 79 citations

Structures of trinucleotide repeats in human transcripts and their functional implications

2003 • 77 citations

Imperfect CAG Repeats Form Diverse Structures in SCA1 Transcripts

2004 • 44 citations

Structure Analysis of MicroRNA Precursors

2006 • 20 citations

CAG and CTG repeat polymorphism in exons of human genes shows distinct features at the expandable loci

2007 • 19 citations

Possible Involvement of the RNAi Pathway in Trinucleotide Repeat Expansion Diseases

2005 • 15 citations

Structural Characteristics of Trinucleotide Repeats in Transcripts

2006 • 5 citations