A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Frailty in Older Adults: Evidence for a Phenotype

2001 • 20,411 citations

Toward an experimental ecology of human development.

1977 • 8,460 citations

Mild Cognitive Impairment

1999 • 8,417 citations

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

2003 • 8,039 citations

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*

2000 • 6,211 citations

Protective and Damaging Effects of Stress Mediators

1998 • 6,197 citations

Epigenetic programming by maternal behavior

2004 • 5,974 citations

Effects of stress throughout the lifespan on the brain, behaviour and cognition

2009 • 5,509 citations

Acute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research.

2004 • 5,374 citations

Socioeconomic Status and Child Development

2002 • 4,987 citations

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions

2000 • 4,657 citations

Stress, Adaptation, and Disease: Allostasis and Allostatic Load

1998 • 4,336 citations

Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain

2007 • 4,139 citations

Constructions of masculinity and their influence on men's well-being: a theory of gender and health

2000 • 3,721 citations

Stress and the Individual

1993 • 3,458 citations

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

2009 • 3,349 citations

Caregiving as a Risk Factor for Mortality

1999 • 3,251 citations

The concept of allostasis in biology and biomedicine

2003 • 3,027 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.

2000 • 3,008 citations

Ecological models of human development

1994 • 2,895 citations

Accelerated telomere shortening in response to life stress

2004 • 2,832 citations

Drug Addiction, Dysregulation of Reward, and Allostasis

2001 • 2,820 citations

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

2001 • 2,667 citations

Risky families: Family social environments and the mental and physical health of offspring.

2002 • 2,622 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

Antipsychotic-Induced Weight Gain: A Comprehensive Research Synthesis

1999 • 2,382 citations

Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite

2004 • 2,291 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Allostatic load biomarkers of chronic stress and impact on health and cognition

2009 • 2,161 citations

What is self-rated health and why does it predict mortality? Towards a unified conceptual model

2009 • 2,161 citations

Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities

2009 • 2,161 citations

Adipokines: inflammation and the pleiotropic role of white adipose tissue

2004 • 2,127 citations

Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study

1990 • 2,107 citations

“Weathering” and Age Patterns of Allostatic Load Scores Among Blacks and Whites in the United States

2005 • 2,089 citations

Regional Development of the Brain in Early Life

1968 • 2,076 citations

Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter

2003 • 2,053 citations

The Influence of Social Hierarchy on Primate Health

2005 • 1,975 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2000 • 1,925 citations

Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy

2002 • 1,922 citations

Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity

2005 • 1,910 citations

Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat

1999 • 1,909 citations

Impact of Gender, Menstrual Cycle Phase, and Oral Contraceptives on the Activity of the Hypothalamus-Pituitary-Adrenal Axis

1999 • 1,825 citations

The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.

2000 • 1,784 citations

Psychiatric and Physical Morbidity Effects of Dementia Caregiving: Prevalence, Correlates, and Causes

1995 • 1,783 citations

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

1996 • 1,759 citations

Protective and Damaging Effects of Mediators of Stress: Elaborating and Testing the Concepts of Allostasis and Allostatic Load

1999 • 1,726 citations

Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators

2008 • 1,715 citations

15-year longitudinal study of blood pressure and dementia

1996 • 1,706 citations

Allostasis and Allostatic Load Implications for Neuropsychopharmacology

2000 • 1,699 citations

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

2002 • 1,691 citations

Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration

2008 • 1,688 citations

Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause

2007 • 1,677 citations

Prevalence of Depression During Pregnancy: Systematic Review

2004 • 1,638 citations

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

2004 • 1,637 citations

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

2009 • 1,636 citations

Mental Health: New Understanding, New Hope

2001 • 1,636 citations

Is Caregiving Hazardous to One's Physical Health? A Meta-Analysis.

2003 • 1,632 citations

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

1998 • 1,613 citations

The link between childhood trauma and depression: Insights from HPA axis studies in humans

2008 • 1,594 citations

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

2002 • 1,579 citations

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

2001 • 1,567 citations

Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials

1995 • 1,526 citations

Protection and Damage from Acute and Chronic Stress: Allostasis and Allostatic Overload and Relevance to the Pathophysiology of Psychiatric Disorders

2004 • 1,516 citations

Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

2010 • 1,508 citations

Sex differences in HPA axis responses to stress: a review

2004 • 1,497 citations

Hippocampal Volume and Depression: A Meta-Analysis of MRI Studies

2004 • 1,491 citations

The perseverative cognition hypothesis: A review of worry, prolonged stress-related physiological activation, and health

2006 • 1,463 citations

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1999 • 1,384 citations

The neurobiological consequences of early stress and childhood maltreatment

2003 • 1,376 citations

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

1999 • 1,371 citations

Depression and Risk for Alzheimer Disease

2006 • 1,348 citations

Handbook of Life Stress, Cognition and Health

1989 • 1,343 citations

Second-Generation (Atypical) Antipsychotics and Metabolic Effects

2005 • 1,335 citations

Addiction and the Brain Antireward System

2007 • 1,317 citations

Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure

1995 • 1,301 citations

The metabolic consequences of sleep deprivation

2007 • 1,285 citations

Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report

1997 • 1,264 citations

Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging

2001 • 1,262 citations

Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis

2005 • 1,258 citations

Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease

2005 • 1,240 citations

Price of Adaptation—Allostatic Load and Its Health Consequences

1997 • 1,234 citations

Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function

2004 • 1,200 citations

Allostasis : a new paradigm to explain arousal pathology

1988 • 1,160 citations

Midlife cardiovascular risk factors and risk of dementia in late life

2005 • 1,154 citations

Developmental ecology through space and time: A future perspective.

2004 • 1,148 citations

A new view on hypocortisolism

2005 • 1,147 citations

Intellectual Impairment in Children Exposed to Polychlorinated Biphenyls in Utero

1996 • 1,137 citations

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

2003 • 1,125 citations

Depression and cortisol responses to psychological stress: A meta-analysis

2005 • 1,122 citations

COMT val ¹⁵⁸ met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

2003 • 1,103 citations

Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis

2004 • 1,101 citations

Mood disorders and allostatic load

2003 • 1,091 citations

The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease

2004 • 1,080 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

1997 • 1,067 citations

Effects of Aerobic Exercise on Mild Cognitive Impairment

2010 • 1,066 citations

Protective and damaging effects of stress mediators: central role of the brain

2006 • 1,057 citations

Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18

1996 • 1,036 citations

Spousal caregivers of dementia victims: longitudinal changes in immunity and health.

1991 • 1,003 citations

Prevalence and Impact of Caregiving: A Detailed Comparison Between Dementia and Nondementia Caregivers

1999 • 986 citations

A Role for Brain Stress Systems in Addiction

2008 • 986 citations

The Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline

2004 • 981 citations

Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study

2006 • 966 citations

Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.

1999 • 964 citations

Course of illness, hippocampal function, and hippocampal volume in major depression

2003 • 962 citations

Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

2007 • 949 citations

Lead Exposure and Cardiovascular Disease—A Systematic Review

2006 • 947 citations

The effects of sex and hormonal status on the physiological response to acute psychosocial stress

2005 • 945 citations

Aerobic fitness is associated with hippocampal volume in elderly humans

2009 • 940 citations

HEALTH PSYCHOLOGY: What is an Unhealthy Environment and How Does It Get Under the Skin?

1997 • 932 citations

Developmental psychopathology: Concepts and challenges

2000 • 919 citations

Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome

2005 • 898 citations

Estrogen Actions Throughout the Brain

2002 • 897 citations

Slow-wave sleep and the risk of type 2 diabetes in humans

2008 • 856 citations

The potential of transdisciplinary research for sustaining and extending linkages between the health and social sciences

1992 • 856 citations

Depression and memory impairment: A meta-analysis of the association, its pattern, and specificity.

1995 • 850 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

A meta-analysis of structural brain abnormalities in PTSD

2006 • 840 citations

The transactional model of development: How children and contexts shape each other.

2009 • 838 citations

Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load

2001 • 836 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Changes in Proinflammatory Cytokine Activity after Menopause

2002 • 826 citations

Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression

2002 • 798 citations

Research strategies for capturing transactional models of development: The limits of the possible

2003 • 793 citations

An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease

2003 • 793 citations

Effect of Stress on the Activity of the Hypothalamic-Pituitary-Gonadal Axis: Peripheral and Central Mechanisms1

1991 • 788 citations

Effect of spiritual well-being on end-of-life despair in terminally-ill cancer patients

2003 • 786 citations

Gonadal Steroid Hormone Receptors and Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis

1994 • 781 citations

Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis

2005 • 780 citations

Aggregation of vascular risk factors and risk of incident Alzheimer disease

2005 • 769 citations

Enhanced memory for emotional material following stress-level cortisol treatment in humans

2001 • 759 citations

H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

2003 • 758 citations

Sex differences in stress responses: social rejection versus achievement stress

2002 • 752 citations

Alcoholism: Allostasis and Beyond

2003 • 738 citations

Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause

2007 • 736 citations

Sex, stress and the hippocampus: allostasis, allostatic load and the aging process

2002 • 725 citations

Functional Cross‐Talk Between the Hypothalamic‐Pituitary‐Gonadal and ‐Adrenal Axes

2002 • 714 citations

Consistent sex differences in cortisol responses to psychological stress.

1992 • 714 citations

Definition of Metabolic Syndrome

2004 • 712 citations

The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES)

1994 • 710 citations

Inflammatory Proteins in Plasma and the Risk of Dementia

2004 • 709 citations

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

1968 • 700 citations

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

2008 • 692 citations

Inflammatory markers and cognition in well-functioning African-American and white elders

2003 • 686 citations

Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study

2002 • 679 citations

Childhood poverty, chronic stress, and adult working memory

2009 • 674 citations

Glucocorticoids, depression, and mood disorders: structural remodeling in the brain

2005 • 671 citations

Neurobiological mechanisms for opponent motivational processes in addiction

2008 • 669 citations

Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

1998 • 669 citations

Effects of Prenatal and Postnatal Methylmercury Exposure From Fish Consumption on Neurodevelopment

1998 • 668 citations

Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

2005 • 667 citations

Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [¹¹C]Raclopride

2004 • 664 citations

The Interaction of Stressful Life Events and a Serotonin Transporter Polymorphism in the Prediction of Episodes of Major Depression

2005 • 652 citations

Psychiatric and Physical Morbidity Effects of Caregiving

1990 • 641 citations

Developmental systems and psychopathology

2000 • 634 citations

Gain in the Caregiving Experience: Where Are We? What Next?

1997 • 633 citations

Bone Lead Levels and Delinquent Behavior

1996 • 628 citations

The brain and the stress axis: The neural correlates of cortisol regulation in response to stress

2009 • 620 citations

A multimethodological analysis of cumulative risk and allostatic load among rural children.

2003 • 610 citations

Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans

1993 • 607 citations

Hot Flashes: Epidemiology and Physiology^a

1990 • 596 citations

Caregiving and risk of coronary heart disease in U.S. women

2003 • 595 citations

Anxiety Disorders During Pregnancy and the Postpartum Period

2006 • 591 citations

The Biological Embedding of Early Experience and Its Effects on Health in Adulthood

1999 • 587 citations

Can poverty get under your skin? Basal cortisol levels and cognitive function in children from low and high socioeconomic status

2001 • 585 citations

Intake of Mercury From Fish, Lipid Peroxidation, and the Risk of Myocardial Infarction and Coronary, Cardiovascular, and Any Death in Eastern Finnish Men

1995 • 585 citations

Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load

2006 • 578 citations

Neurobiological mechanisms in the transition from drug use to drug dependence

2003 • 575 citations

Stress and the Hypothalamic Pituitary Adrenal Axis in the Developmental Course of Schizophrenia

2008 • 574 citations

Sex-Specific Effects of Social Support on Cortisol and Subjective Responses to Acute Psychological Stress

1995 • 570 citations

Religiosity/spirituality and health: A critical review of the evidence for biological pathways.

2003 • 566 citations

Basal cortisol levels and cognitive deficits in human aging

1994 • 564 citations

HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression

2007 • 562 citations

Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways

2006 • 559 citations

The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.

1992 • 557 citations

Developmental determinants of sensitivity and resistance to stress

2005 • 555 citations

Stress hormones and human memory function across the lifespan

2004 • 545 citations

Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state

2000 • 540 citations

Neurocognitive Effects of Clozapine, Olanzapine, Risperidone, and Haloperidol in Patients With Chronic Schizophrenia or Schizoaffective Disorder

2002 • 536 citations

The Decline in Blood Lead Levels in the United States

1994 • 531 citations

Hormones and mood: from menarche to menopause and beyond

2003 • 526 citations

The past achievements and future promises of developmental psychopathology: the coming of age of a discipline

2008 • 521 citations

Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991)

1994 • 519 citations

One-year Age Changes in MRI Brain Volumes in Older Adults

2000 • 515 citations

Interleukin-6 and risk of cognitive decline

2002 • 510 citations

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

2004 • 509 citations

Social Relationships, Gender, and Allostatic Load Across Two Age Cohorts

2002 • 500 citations

Expanding stress theory: Prolonged activation and perseverative cognition

2005 • 491 citations

Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder

2003 • 480 citations

Allostatic load, social status and stress hormones: the costs of social status matter

2004 • 473 citations

Oestrogen as a neuroprotective hormone

2002 • 472 citations

MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health.

2001 • 472 citations

Allostatic load in bipolar disorder: Implications for pathophysiology and treatment

2007 • 470 citations

Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes

2007 • 470 citations

A 32-Year Prospective Study of Change in Body Weight and Incident Dementia

2005 • 469 citations

Gender differences in chronic major and double depression

2000 • 467 citations

Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment

2004 • 465 citations

Health effects of caregiving: The caregiver health effects study: An ancillary study of the cardiovascular health study

1997 • 460 citations

Allostatic load as a predictor of functional decline

2002 • 459 citations

The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1987 • 456 citations

Fifteen Years after “Wingspread”—Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go

2008 • 447 citations

Intrathecal inflammation precedes development of Alzheimer's disease

2003 • 447 citations

Regulation of Adult Neurogenesis by Antidepressant Treatment

2001 • 446 citations

Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity

2001 • 446 citations

Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years

2006 • 442 citations

Neurobiological substrates for the dark side of compulsivity in addiction

2008 • 435 citations

Blood Lead Below 0.48 μmol/L (10 μg/dL) and Mortality Among US Adults

2006 • 427 citations

Diverse patterns of neuroendocrine activity in maltreated children

2001 • 424 citations

Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences

2000 • 423 citations

Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD

2001 • 423 citations

INDUCTION OF CORTICOTROPIN-RELEASING HORMONE GENE EXPRESSION BY GLUCOCORTICOIDS: IMPLICATION FOR UNDERSTANDING THE STATES OF FEAR AND ANXIETY AND ALLOSTATIC LOAD

1998 • 422 citations

Distribution of Corticosteroid Receptors in the Rhesus Brain: Relative Absence of Glucocorticoid Receptors in the Hippocampal Formation

2000 • 422 citations

Catechol-O-Methyltransferaseval¹⁵⁸metGenotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex

2005 • 421 citations

Adverse Effects of Atypical Antipsychotics

2007 • 413 citations

Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder

2001 • 406 citations

Psychological and metabolic stress: A recipe for accelerated cellular aging?

2009 • 405 citations

Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis

2008 • 400 citations

Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity

2004 • 398 citations

Toxicokinetics of bone lead.

1991 • 396 citations

Early life influences on life‐long patterns of behavior and health

2003 • 395 citations

A Longitudinal Study of Hippocampal Volume, Cortisol Levels, and Cognition in Older Depressed Subjects

2004 • 393 citations

A meta-analysis of cortisol response to challenge in human aging: importance of gender

2004 • 393 citations

Metabolic Cardiovascular Syndrome and Risk of Dementia in Japanese-American Elderly Men

2000 • 390 citations

Exposure of the U.S. population to lead, 1991-1994.

1998 • 383 citations

Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia

2006 • 382 citations

Allostasis and Allostatic Load

2007 • 380 citations

Allostasis, amygdala, and anticipatory angst

1994 • 378 citations

Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders

2002 • 377 citations

Association Between Sleep and Blood Pressure in Midlife

2009 • 377 citations

Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies

2005 • 374 citations

Hippocampal volume in geriatric depression

2000 • 371 citations

The Long-Term Effects of Parental Divorce on the Mental Health of Young Adults: A Developmental Perspective

1995 • 363 citations

Increase in Urinary Cortisol Excretion and Memory Declines: MacArthur Studies of Successful Aging1

1997 • 361 citations

Impact of Maternal Seafood Diet on Fetal Exposure to Mercury, Selenium, and Lead

1992 • 358 citations

Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999–2002

2007 • 356 citations

What is stress?

1956 • 355 citations

Evolution of concepts of stress

2007 • 351 citations

Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder

2007 • 351 citations

Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging

2003 • 349 citations

Nicotine-Haloperidol Interactions and Cognitive Performance in Schizophrenics

1996 • 346 citations

Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly

2003 • 343 citations

Cumulative risk, maternal responsiveness, and allostatic load among young adolescents.

2007 • 342 citations

Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder

2004 • 342 citations

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

2005 • 342 citations

Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment

2004 • 339 citations

Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function

2007 • 338 citations

Allostasis and the human brain: Integrating models of stress from the social and life sciences.

2010 • 338 citations

Serum inflammatory proteins and cognitive decline in older persons

2005 • 332 citations

Neural correlates of epigenesis

2006 • 330 citations

A rationale for lowering the blood lead action level from 10 to 2μg/dL

2006 • 330 citations

A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder

2001 • 330 citations

The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function

2002 • 327 citations

Androgen regulation of adrenocorticotropin and corticosterone secretion in the male rat following novelty and foot shock stressors

1994 • 325 citations

The Differential Impacts of Early Physical and Sexual Abuse and Internalizing Problems on Daytime Cortisol Rhythm in School‐Aged Children

2010 • 324 citations

Child development and long-term outcomes: A population health perspective and summary of successful interventions

1996 • 323 citations

Trends in Blood Lead Levels and Blood Lead Testing Among US Children Aged 1 to 5 Years, 1988–2004

2009 • 316 citations

A Review of Psychoendocrine Research on the Sympathetic-Adrenal Medullary System

1968 • 316 citations

Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges

2004 • 313 citations

Systemic Markers of Inflammation and Cognitive Decline in Old Age

2007 • 311 citations

Socio-economic status, cortisol and allostatic load: a review of the literature

2009 • 310 citations

Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

2005 • 309 citations

Vascular factors predict rate of progression in Alzheimer disease

2007 • 306 citations

Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus

2007 • 306 citations

Focal Gray Matter Changes in Schizophrenia across the Course of the Illness: A 5-Year Follow-Up Study

2007 • 304 citations

Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia

2008 • 301 citations

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

1996 • 291 citations

Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics

2004 • 291 citations

Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial

1998 • 287 citations

Continued Decline in Blood Lead Levels Among Adults in the United States

2005 • 285 citations

The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction

2008 • 285 citations

Greater Cortical Gray Matter Density in Lithium-Treated Patients with Bipolar Disorder

2007 • 285 citations

Cytokine profiles in bipolar affective disorder: Focus on acutely ill patients

2006 • 283 citations

Blood Lead Levels in the US Population

1994 • 283 citations

Age differences in allostatic load: an index of physiological dysregulation

2003 • 282 citations

Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition

2000 • 278 citations

Plasma Total Cholesterol Level as a Risk Factor for Alzheimer Disease

2003 • 276 citations

Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast

2006 • 276 citations

Preventive Health Behaviors among Spousal Caregivers

1997 • 275 citations

Association of Anticholinergic Load With Impairment of Complex Attention and Memory in Schizophrenia

2004 • 274 citations

In Harm’s Way: Toxic Threats to Child Development

2002 • 270 citations

Reduction in Allostatic Load in Older Adults Is Associated With Lower All-Cause Mortality Risk: MacArthur Studies of Successful Aging

2006 • 264 citations

Site-Specific Role of Catechol-O-Methyltransferase in Dopamine Overflow within Prefrontal Cortex and Dorsal Striatum

2007 • 263 citations

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

2008 • 262 citations

Associations of Salivary Cortisol With Cognitive Function in the Baltimore Memory Study

2007 • 261 citations

Gender differences in hypothalamic–pituitary–adrenal (HPA) axis reactivity

2006 • 259 citations

Blood Lead, Blood Pressure, and Hypertension in Perimenopausal and Postmenopausal Women

2003 • 250 citations

The testosterone–cortisol ratio: A hormonal marker for proneness to social aggression

2009 • 249 citations

Diabetes mellitus in midlife and the risk of dementia three decades later

2004 • 249 citations

Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure

2003 • 249 citations

Immune variations in bipolar disorder: phasic differences

2007 • 245 citations

History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease

2008 • 242 citations

Physical Activity and Incident Cognitive Impairment in Elderly Persons

2010 • 241 citations

Combinations of biomarkers predictive of later life mortality

2006 • 238 citations

Immune‐inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine

1994 • 238 citations

The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease

2009 • 234 citations

The Amygdala: Corticotropin-Releasing Factor, Steroids, and Stress

1996 • 233 citations

Adolescents’ cortisol responses to awakening and social stress; Effects of gender, menstrual phase and oral contraceptives. The TRAILS study

2009 • 231 citations

Effects of Childhood Sexual Abuse on Neuropsychological and Cognitive Function in College Women

2006 • 229 citations

The Long-Term Effects of Parental Divorce on the Mental Health of Young Adults: A Developmental Perspective

1995 • 228 citations

Evidence of basal pituitary–adrenal overactivity in first episode, drug naïve patients with schizophrenia

2003 • 228 citations

Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women1

1999 • 223 citations

Effect of testosterone on abdominal adipose tissue in men.

1991 • 222 citations

Hierarchies of Life Histories and Associated Health Risks

1999 • 221 citations

Social Structure, Life Stress, and Depressive Symptoms in a High School-Age Population

1992 • 218 citations

Reduced Antibody Responses to Vaccinations in Children Exposed to Polychlorinated Biphenyls

2006 • 218 citations

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons

2006 • 217 citations

The Metabolic Syndrome and Development of Cognitive Impairment Among Older Women

2009 • 217 citations

Androgen Receptor Gene CAG Repeat Length and Body Mass Index Modulate the Safety of Long-Term Intramuscular Testosterone Undecanoate Therapy in Hypogonadal Men

2007 • 217 citations

Can Antidepressants Be Used to Treat the Schizophrenia Prodrome?

2007 • 216 citations

Heart rate response is longer after negative emotions than after positive emotions

2003 • 216 citations

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

2008 • 216 citations

Brain imaging evidence of preclinical Alzheimer's disease in normal aging

2006 • 214 citations

Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication

1995 • 212 citations

Age effects on atrophy rates of entorhinal cortex and hippocampus

2005 • 212 citations

Frailty syndrome and the risk of vascular dementia: The Italian Longitudinal Study on Aging

2012 • 211 citations

Neurocognitive Aging and Cardiovascular Fitness: Recent Findings and Future Directions

2004 • 211 citations

The neurocognitive effects of low-dose haloperidol: a two-year comparison with risperidone

2002 • 209 citations

Fibrinogen Is Associated With an Increased Risk of Alzheimer Disease and Vascular Dementia

2005 • 208 citations

Deficits in Verbal Declarative Memory Function in Women With Childhood Sexual Abuse-Related Posttraumatic Stress Disorder

2004 • 207 citations

Relationship of Lead, Mercury, Mirex, Dichlorodiphenyldichloroethylene, Hexachlorobenzene, and Polychlorinated Biphenyls to Timing of Menarche Among Akwesasne Mohawk Girls

2005 • 207 citations

Metabolic Syndrome and Cognitive Decline in Elderly Latinos: Findings from the Sacramento Area Latino Study of Aging Study

2007 • 206 citations

Association between late-life body mass index and dementia

2009 • 204 citations

Role of PDGF in fibrotic diseases and systemic sclerosis

2008 • 201 citations

Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study

2007 • 200 citations

Clozapine decreases smoking in patients with chronic schizophrenia

1995 • 200 citations

A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment

2004 • 199 citations

Cortisol and Cytokines in Chronic and Treatment-Resistant Patients with Schizophrenia: Association with Psychopathology and Response to Antipsychotics

2005 • 198 citations

Anxiety disorders in women

2003 • 198 citations

Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues.

1992 • 197 citations

Links between cognitive impairment in insulin resistance: An explanatory model

2005 • 197 citations

Women and heart disease

1998 • 196 citations

Allostatic Load and Frailty in Older Adults

2009 • 191 citations

Chronic work stress and exhaustion is associated with higher allostastic load in female school teachers

2008 • 190 citations

A Prospective Study on Cortisol, Dehydroepiandrosterone Sulfate, and Cognitive Function in the Elderly

1998 • 190 citations

The metabolic syndrome is associated with decelerated cognitive decline in the oldest old

2007 • 189 citations

Deficits in Hippocampal and Anterior Cingulate Functioning During Verbal Declarative Memory Encoding in Midlife Major Depression

2004 • 188 citations

The Serotonin Transporter Promoter Polymorphism Is Associated with Cortisol Response to Psychosocial Stress

2009 • 188 citations

Maternal Care Modulates the Relationship between Prenatal Risk and Hippocampal Volume in Women But Not in Men

2007 • 187 citations

Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans.

1992 • 187 citations

Psychosocial Modulation of Cytokine-Induced Natural Killer Cell Activity in Older Adults

1996 • 186 citations

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population

2007 • 185 citations

Heritability of hippocampal size in elderly twin men: Equivalent influence from genes and environment

2001 • 183 citations

The neurobiology and neuroendocrinology of stress

2002 • 183 citations

Twenty-six–Year Change in Total Cholesterol Levels and Incident Dementia

2007 • 183 citations

A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers

2010 • 181 citations

Prenatal Exposure to Polychlorinated Biphenyls: A Neuropsychologic Analysis

2008 • 179 citations

The impact of social experience on neurobiological systems: illustration from a constructivist view of child maltreatment

2002 • 178 citations

Psychosocial stress and the insulin resistance syndrome

1996 • 178 citations

Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium

2008 • 175 citations

Circadian Rhythm of Salivary Cortisol in Holocaust Survivors With and Without PTSD

2005 • 175 citations

Maternal stress modulates the effects of developmental lead exposure.

2004 • 175 citations

A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon

2006 • 174 citations

Sleep and Depression in Cancer Caregivers

2000 • 173 citations

Allostatic load and work conditions

2003 • 171 citations

Verbal memory performance of patients with a first depressive episode and patients with unipolar and bipolar recurrent depression

2003 • 171 citations

Hypothalamic-Pituitary-Adrenal Axis Dysregulation and Memory Impairments in Type 2 Diabetes

2007 • 171 citations

Effects of Chronic Stress on Memory Decline in Cognitively Normal and Mildly Impaired Older Adults

2009 • 169 citations

Prevalence of Metabolic Syndrome Associated with Body Burden Levels of Dioxin and Related Compounds among Japan’s General Population

2008 • 167 citations

Mood and neuropsychological function in depression: the role of corticosteroids and serotonin

1998 • 167 citations

Endocrine and metabolic dysfunction in yellow perch, Perca flavescens, exposed to organic contaminants and heavy metals in the ST. Lawrence river

1995 • 167 citations

Neuroendocrinological Mechanisms of Actions of Antidepressant Drugs

2006 • 166 citations

Cynical hostility: Developmental factors, psychosocial correlates, and health behaviors.

1991 • 166 citations

Epigenetic mechanisms in schizophrenia

2009 • 166 citations

Metabolic Syndrome and Dementia Risk in a Multiethnic Elderly Cohort

2007 • 165 citations

Twin study of the 24-h cortisol profile: evidence for genetic control of the human circadian clock

1993 • 165 citations

Impact of a Child's Chronic Illness on Maternal Sleep and Daytime Functioning

2006 • 164 citations

Chronic Stress‐Induced Effects of Corticosterone on Brain: Direct and Indirect

2004 • 161 citations

Endogenous sex hormone levels and cognitive function in aging men

2005 • 161 citations

Caregiving Strain and Estimated Risk for Stroke and Coronary Heart Disease Among Spouse Caregivers

2010 • 160 citations

Long–term Psychosocial effects of parental divorce

2006 • 160 citations

The relationship between testosterone and molecular markers of inflammation in older men.

2005 • 160 citations

Sleep Complaints in Older Women Who Are Family Caregivers

1999 • 159 citations

Hormone therapy, timing of initiation, and cognition in women aged older than 60 years: the REMEMBER pilot study

2006 • 159 citations

Hippocampal volume is as variable in young as in older adults: Implications for the notion of hippocampal atrophy in humans

2006 • 157 citations

Lifetime Low-Level Exposure to Environmental Lead and Children's Emotional and Behavioral Development at Ages 11-13 Years: The Port Pirie Cohort Study

1999 • 157 citations

Patient Suffering and Caregiver Compassion: New Opportunities for Research, Practice, and Policy

2007 • 157 citations

Serum cholesterol and risk of Alzheimer disease

2005 • 155 citations

Social Inequalities in Biomarkers of Cardiovascular Risk in Adolescence

2005 • 153 citations

Ambulatory Blood Pressure and Heart Rate Responses to the Stress of Work and Caregiving in Older Women

1994 • 152 citations

Food Intake and Reward Mechanisms in Patients with Schizophrenia: Implications for Metabolic Disturbances and Treatment with Second-Generation Antipsychotic Agents

2006 • 152 citations

Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism

2004 • 152 citations

Reproductive Period and Risk of Dementia in Postmenopausal Women

2001 • 150 citations

Weight gain associated with the −759C/T polymorphism of the 5HT2C receptor and olanzapine

2005 • 149 citations

Long-Term Outcomes of Early Childhood Programs: Analysis and Recommendations

1995 • 149 citations

A comparative analysis of measurement approaches for physiological dysregulation in an older population

2005 • 144 citations

Influence of menopause on diabetes and diabetes risk

2009 • 144 citations

Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect

2006 • 144 citations

High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder

2003 • 143 citations

Do Chronic Stressors Lead to Physiological Dysregulation? Testing the Theory of Allostatic Load

2007 • 142 citations

The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects

2006 • 140 citations

A Prospective Study of Dehydroepiandrosterone Sulfate and Cognitive Function in an Older Population: The Rancho Bernardo Study

1994 • 140 citations

Effect of Prenatal Exposure to Polychlorinated Biphenyls on Incidence ofAcute Respiratory Infections in Preschool Inuit Children

2006 • 138 citations

Blood Lead Levels and Major Depressive Disorder, Panic Disorder, and Generalized Anxiety Disorder in US Young Adults

2009 • 136 citations

Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children

2004 • 135 citations

Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome

2009 • 134 citations

Immunologic effects of dioxin: new results from Seveso and comparison with other studies.

2002 • 134 citations

Excitability of Dopamine Neurons: Modulation and Physiological Consequences

2006 • 134 citations

Salivary cortisol and memory function in human aging

2005 • 132 citations

Using Basic Science to Design a Clinical Trial: Baseline Characteristics of Women Enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)

2009 • 131 citations

Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder

2007 • 131 citations

Neurobehavioral Effects of Developmental Methylmercury Exposure

1995 • 130 citations

Social relationships and allostatic load in Taiwanese elderly and near elderly

2004 • 130 citations

Neuroleptic dysphoria: towards a new synthesis

2004 • 129 citations

Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study

2009 • 129 citations

Cynical hostility: Developmental factors, psychosocial correlates, and health behaviors.

1991 • 129 citations

Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Alzheimer's Disease: Lack of Association Between Longitudinal and Cross-Sectional Findings

1998 • 128 citations

Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging

2010 • 128 citations

Sex differences and the HPA axis: implications for psychiatric disease.

1998 • 128 citations

Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer’s disease

2009 • 128 citations

Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study.

1997 • 128 citations

Behavioral Problems in Dementia Patients and Salivary Cortisol Patterns in Caregivers

2005 • 127 citations

A comparison of primary stressors, secondary stressors, and depressive symptoms between elderly caregiving husbands and wives: The caregiver health effects study.

2000 • 127 citations

Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia

2006 • 127 citations

Inflammation and Rate of Cognitive Change in High-Functioning Older Adults

2008 • 126 citations

Gender differences in the link between childhood socioeconomic conditions and heart attack risk in adulthood

2007 • 125 citations

Cognitive function in unaffected twins discordant for affective disorder

2006 • 124 citations

Variations in Heritability of Cortisol Reactivity to Stress as a Function of Early Familial Adversity Among 19-Month-Old Twins

2008 • 122 citations

Complexity and human health: the case for a transdisciplinary paradigm.

1998 • 122 citations

Religious Service Attendance and Allostatic Load Among High-Functioning Elderly

2007 • 121 citations

Oxidative Damage and Schizophrenia: The Potential Benefit by Atypical Antipsychotics

2004 • 120 citations

Fish Consumption, Mercury Exposure, and Heart Diseases

2004 • 120 citations

The dioxin-like pollutant PCB 126 (3,3′,4,4′,5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats

2004 • 120 citations

The Critical Period Hypothesis: Can It Explain Discrepancies in the Oestrogen‐Cognition Literature?

2006 • 119 citations

Toward Transdisciplinary Research

2008 • 119 citations

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

2009 • 118 citations

Dementia Patient Suffering and Caregiver Depression

2008 • 118 citations

Oxidative Stress During Treatment With First- and Second-Generation Antipsychotics

2005 • 117 citations

Cortisol Secretion and Alzheimer’s Disease Progression

1997 • 117 citations

The 24-Hour Profiles of Cortisol, Prolactin, and Growth Hormone Secretion in Mania

1994 • 116 citations

Immunologic variables in acute mania of bipolar disorder

2004 • 116 citations

The neurotrophic and neuroprotective effects of psychotropic agents

2009 • 115 citations

Preliminary evidence that estrogen protects against age-related hippocampal atrophy

2002 • 114 citations

Lifetime Consequences of Combined Maternal Lead and Stress

2008 • 113 citations

Interactions of Chronic Lead Exposure and Intermittent Stress: Consequences for Brain Catecholamine Systems and Associated Behaviors and HPA Axis Function

2005 • 113 citations

Activation of indices of cell-mediated immunity in bipolar mania

1999 • 112 citations

Environmental stress, psychological stress and allostatic load

2006 • 112 citations

Organochlorines Affect the Steroid Hormone Cortisol in Free-Ranging Polar Bears (Ursus maritimus) at Svalbard, Norway

2004 • 110 citations

Allostasis: a neural behavioral perspective

2003 • 110 citations

Psychosocial factors associated with cardiovascular reactivity in older adults.

1993 • 109 citations

The relation of environmental contaminants exposure to behavioral indicators in Inuit preschoolers in Arctic Quebec

2009 • 109 citations

A comparison of primary stressors, secondary stressors, and depressive symptoms between elderly caregiving husbands and wives: The caregiver health effects study.

2000 • 109 citations

Corticosteroids, the Aging Brain and Cognition

1999 • 109 citations

Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women

1999 • 108 citations

Altered circadian cortisol secretion in Alzheimer's disease: Clinical and neuroradiological aspects

2001 • 106 citations

Urinary cortisol excretion as a predictor of incident cognitive impairment

2005 • 105 citations

LITHIUM TREATMENT AND WEIGHT GAIN

1976 • 104 citations

Perceived stress and physiological dysregulation in older adults

2005 • 103 citations

In vivo testing of the functional integrity of the corticosterone‐producing axis in mudpuppy (amphibia) exposed to chlorinated hydrocarbons in the wild

1997 • 103 citations

Sleep disturbances in spousal caregivers of individuals with Alzheimer's disease

2007 • 103 citations

Sleep in Spousal Caregivers of People With Alzheimer's Disease

2005 • 101 citations

Regulation of dendritic cells by female sex steroids: Relevance to immunity and autoimmunity

2007 • 101 citations

Metabolic Syndrome and Risk of Dementia in Older Adults

2010 • 101 citations

Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause

2007 • 99 citations

How Are Biomarkers Related to Physical and Mental Well-Being?

2004 • 98 citations

Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women

2004 • 98 citations

Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children

2007 • 96 citations

Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia

2003 • 95 citations

Is the Estrogen Controversy Over? Deconstructing the Women's Health Initiative Study: A Critical Evaluation of the Evidence

2005 • 94 citations

Relocation of children after divorce and children's best interests: New evidence and legal considerations.

2003 • 94 citations

Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients.

1999 • 93 citations

Depression, traumatic stress and interleukin-6

2009 • 93 citations

The Testicular Effects of Tumor Necrosis Factor

1990 • 92 citations

Increased Levels of Nitric Oxide, Cortisol and Adrenomedullin in Patients with Chronic Schizophrenia

2007 • 92 citations

Postpartum onset obsessive-compulsive disorder: diagnosis and management

2004 • 92 citations

Distressing Emotions in Female Caregivers of People With AIDS, Age-Related Dementias, and Advanced-Stage Cancers

2009 • 91 citations

Plasma cortisol levels in elderly female subjects with Alzheimer’s disease: a cross-sectional and longitudinal study

2000 • 90 citations

Midlife C-reactive protein and risk of cognitive decline: A 31-year follow-up

2008 • 88 citations

Sex-Related Differences in Stimulated Hypothalamic-Pituitary-Adrenal Axis during Induced Gonadal Suppression

2005 • 88 citations

Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics

2005 • 88 citations

Allostatic Load in Women With and Without PTSD Symptoms

2006 • 87 citations

Platelet serotonin, plasma cortisol, and dexamethasone suppression test in schizophrenic patients

1999 • 86 citations

Lithium Augmentation Increases the ACTH and Cortisol Response in the Combined DEX/CRH Test in Unipolar Major Depression,

2002 • 86 citations

Bivariate Genetic Modeling of Cardiovascular Stress Reactivity: Does Stress Uncover Genetic Variance?

2007 • 85 citations

Spironolactone in the treatment of polycystic ovary syndrome: Effects on clinical features, insulin sensitivity and lipid profile

2005 • 84 citations

Self-rated recovery from work stress and allostatic load in women

2006 • 84 citations

Inflammatory, Lipid, Thrombotic, and Genetic Markers of Coronary Heart Disease Risk in the Women's Health Initiative Trials of Hormone Therapy

2008 • 83 citations

Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia

2002 • 82 citations

Impaired cortisol secretion in yellow perch (Perca flavescens) from lakes contaminated by heavy metals: in vivo and in vitro assessment

1997 • 82 citations

Low-Level Lead Exposure Selectively Enhances Dopamine Overflow in Nucleus Accumbens: AnIn VivoElectrochemistry Time Course Assessment

1998 • 82 citations

Does Caregiving Stress Affect Cognitive Function in Older Women?

2003 • 81 citations

Measurement of cumulative physiological dysregulation in an older population

2006 • 81 citations

Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics

2009 • 81 citations

Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment

2008 • 81 citations

Screening tools for depression in primary care: The effects of culture, gender, and somatic symptoms on the detection of depression

2001 • 80 citations

Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse

2003 • 80 citations

Assessing the cumulative effects of stress: The association between job stress and allostatic load in a large sample of Chinese employees

2007 • 80 citations

Neurobehavioral effects of developmental methylmercury exposure.

1995 • 80 citations

Peripheral Levels of Fibrinogen, C-Reactive Protein, and Plasma Viscosity Predict Future Cognitive Decline in Individuals Without Dementia

2009 • 79 citations

Menstrual cycle status and adrenocortical reactivity to pyschological stress☆

1976 • 79 citations

Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood

2006 • 79 citations

Pharmacogenetics of antipsychotic-induced weight gain

2004 • 78 citations

The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia

2006 • 77 citations

Hippocampal volume is an independent predictor of cognitive performance in CADASIL

2007 • 77 citations

Physiological dysregulation and changes in health in an older population

2006 • 77 citations

Metabolism, mood and cognition in aging: The importance of lifestyle and dietary intervention

2005 • 77 citations

Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response

2007 • 76 citations

Allostatic Load and Frailty in the Women's Health and Aging Studies

2008 • 76 citations

Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups

2004 • 75 citations

Interactions between methylsulfonyl PCBs and the glucocorticoid receptor.

1998 • 75 citations

The relation of low-level prenatal lead exposure to behavioral indicators of attention in Inuit infants in Arctic Quebec

2007 • 73 citations

Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine

2005 • 73 citations

Nicotine Decreases Bradykinesia-rigidity in Haloperidol-treated Patients with Schizophrenia

2002 • 72 citations

Sex Hormones, Insulin Sensitivity, and Diabetes Mellitus

2004 • 72 citations

Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein

2009 • 71 citations

Prenatal and early childhood blood lead levels and cardiovascular functioning in 9½ year old children

2005 • 71 citations

Apolipoprotein E genotyping as a potential biomarker for mercury neurotoxicity

2003 • 70 citations

Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment

2003 • 70 citations

Effects of dietary PCB exposure on adrenocortical function in captive American kestrels (Falco sparverius).

2003 • 69 citations

ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia

2004 • 69 citations

PCB126 Induces Differential Changes in Androgen, Cortisol, and Aldosterone Biosynthesis in Human Adrenocortical H295R Cells

2005 • 68 citations

Early Age at Menarche and Allostatic Load: Data from the Third National Health and Nutrition Examination Survey

2005 • 68 citations

Heritability of daytime cortisol levels and cortisol reactivity in children

2008 • 67 citations

Sociodemographic aspects of human susceptibility to toxic chemicals:

1997 • 67 citations

Higher Basal Cortisol Predicts Verbal Memory Loss in Postmenopausal Women: Rancho Bernardo Study

2000 • 67 citations

Clozapine Enhances Neurocognition and Clinical Symptomatology More Than Standard Neuroleptics

2001 • 66 citations

Metabolic Syndrome and Cognitive Decline in Chinese Older Adults: Results From the Singapore Longitudinal Ageing Studies

2008 • 65 citations

Genetic influences on cardiovascular stress reactivity

2009 • 65 citations

Cellular immune responses to acute stress in female caregivers of dementia patients and matched controls.

1998 • 65 citations

Estrogen and cerebral blood flow: a mechanism to explain the impact of estrogen on the incidence and treatment of Alzheimer's disease.

2000 • 64 citations

Relationships Between Caregiver Stress and Self-Care Behaviors in Response to Symptoms

2007 • 64 citations

Effect of estrogen on cerebral glucose metabolism in postmenopausal women

2000 • 64 citations

Aβ42-to-Aβ40- and Angiotensin-converting Activities in Different Domains of Angiotensin-converting Enzyme

2009 • 63 citations

A life-span perspective on women's careers, health, and well-being

2007 • 63 citations

Smallpox Revisited

2002 • 63 citations

Predicting Mortality From Clinical and Nonclinical Biomarkers

2006 • 62 citations

Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study

2007 • 61 citations

Elevated C‐Reactive Protein Is Related to Cognitive Decline in Older Adults with Cardiovascular Disease

2008 • 61 citations

Is burnout related to allostatic load?

2007 • 61 citations

The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects

2004 • 60 citations

Major system toxicities and side effects of anticonvulsants.

2001 • 59 citations

Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment

2009 • 59 citations

The Effects of Maltreatment and Neuroendocrine Regulation on Memory Performance

2010 • 59 citations

Cognitive and Noncognitive Symptoms in Dementia Patients: Relationship to Cortisol and Dehydroepiandrosterone

1998 • 59 citations

Effect of psychotropic agents upon the blastogenic response of human t-lymphocytes.

1977 • 59 citations

Oestrogens in rheumatic diseases: friend or foe?

2008 • 58 citations

Acute changes in circulating hormones in older patients with impaired ventricular function undergoing on-pump coronary artery bypass grafting

2005 • 58 citations

Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release

2005 • 58 citations

Markers of inflammation and cognitive decline in an African‐Caribbean population

2007 • 58 citations

Pharmacotherapy for schizophrenia and co-occurring substance use disorders

2003 • 58 citations

Stress: Neurobiology and Neuroendocrinology

1991 • 57 citations

Is Sticky Blood Bad for the Brain?

2009 • 57 citations

Role of glucocorticoids in the regulation of dopaminergic neurotransmission.

2004 • 57 citations

The Health Impact of Living with a Cognitively Impaired Elderly Spouse

1992 • 56 citations

Lipids and Lipoproteins in Women

1997 • 56 citations

Mercury in hair and blood from residents of Phnom Penh (Cambodia) and possible effect on serum hormone levels

2007 • 56 citations

Cadmium Exposure Is Associated With Elevated Blood C-Reactive Protein and Fibrinogen in the U. S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)

2009 • 55 citations

Lifelong Endocrine Fluctuations and Related Cognitive Disorders

2005 • 55 citations

The BDNF Val66Met polymorphism: Relation to familiar risk of affective disorder, BDNF levels and salivary cortisol

2009 • 55 citations

Switch from neuroleptics to clozapine does not influence pituitary–gonadal axis hormone levels in male schizophrenic patients

1999 • 55 citations

Influence of maternal ingestion of aroclor 1254� (PCB) or firemaster BP-6� (PBB) on unstimulated and stimulated corticosterone levels in young rats

1992 • 54 citations

How gene–stress–behavior interactions can promote adolescent alcohol use: The roles of predrinking allostatic load and childhood behavior disorders

2006 • 54 citations

Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study.

2004 • 54 citations

Effects of haloperidol and amisulpride on motor and cognitive skill learning in healthy volunteers

1997 • 53 citations

Using Biologic Markers in Blood to Assess Exposure to Multiple Environmental Chemicals for Inner-City Children 3–6 Years of Age

2005 • 53 citations

Male caregivers of spouses with Alzheimer's disease: Risk factors and health status

2001 • 52 citations

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

2005 • 52 citations

Acute procoagulant stress response as a dynamic measure of allostatic load in alzheimer caregivers

2003 • 51 citations

MENTAL HEALTH AND SLEEP OF OLDER WIFE CAREGIVERS FOR SPOUSES WITH ALZHEIMER'S DISEASE AND RELATED DISORDERS

2006 • 51 citations

Levels and confounders of morning cortisol collected from adolescents in a naturalistic (school) setting

2008 • 49 citations

Genetic Dominance Influences Blood Biomarker Levels in a Sample of 12,000 Swedish Elderly Twins

2009 • 49 citations

Vascular risk factors and cognitive decline among elderly male twins

2006 • 49 citations

Hyperlipidemia in Persons Using Antipsychotic Medication

2004 • 49 citations

Allostatic Load is Associated with Symptoms in Chronic Fatigue Syndrome Patients

2006 • 48 citations

The prevalence of cortical gray matter atrophy may be overestimated in the healthy aging brain.

2009 • 48 citations

Influence of low level maternal Pb exposure and prenatal stress on offspring stress challenge responsivity

2008 • 47 citations

Allostatic Load and Clinical Risk as Related to Sense of Coherence in Middle-Aged Women

2006 • 47 citations

State and trait related predictors of serum cortisol to DHEA(S) molar ratios and hormone concentrations in schizophrenia patients

2006 • 47 citations

Behavioral Versus Genetic Correlates of Lipoproteins and Adiposity in Identical Twins Discordant for Exercise

2005 • 46 citations

Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy

2001 • 46 citations

Increase in epinephrine excretion is associated with cognitive decline in elderly men: MacArthur studies of successful aging

2005 • 45 citations

Protective environments and health status: Cross-talk between human and animal studies

2005 • 45 citations

Chronic Fatigue Syndrome and High Allostatic Load

2006 • 45 citations

Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment

2009 • 44 citations

Risk Assessment for Children and Other Sensitive Populations

1999 • 43 citations

Altered Stress-Induced Cortisol Levels in Goats Exposed to Polychlorinated Biphenyls (PCB 126 and PCB 153) During Fetal and Postnatal Development

2009 • 43 citations

Biopsychological Markers of Distress in Informal Caregivers

2004 • 42 citations

Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Stimulation Test in Studies of Depression, Alcoholism, and Suicidal Behavior

2006 • 42 citations

Neuroendocrine biomarkers, allostatic load, and the challenge of measurement: A commentary on Gersten

2007 • 42 citations

Prediction of depressive relapse in remitted bipolar patients using corticotrophin‐releasing hormone challenge test

1997 • 41 citations

Testosterone: a natural tonic for the failing heart?

2000 • 41 citations

Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments

2006 • 41 citations

Sleep Disturbances, Daytime Sleepiness, and Quality of Life in Adults with Growth Hormone Deficiency

2010 • 40 citations

Social rehabilitation of separation-induced depressive disorders in monkeys

1976 • 40 citations

Composite estimates of physiological stress, age, and diabetes in American Samoans

2007 • 39 citations

Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action

2008 • 39 citations

Chronic Fatigue Syndrome and High Allostatic Load: Results From a Population-Based Case-Control Study in Georgia

2009 • 38 citations

The dexamethasone suppression test in schizophrenia

1998 • 38 citations

Prophecies of childhood: How children’s social environments and biological propensities affect the health of populations

2004 • 37 citations

Blood lead (Pb) levels: Further evidence for an environmental mechanism explaining the association between socioeconomic status and psychophysiological dysregulation in children.

2009 • 37 citations

Inhibition by chlorpromazine of lymphokine‐specific mRNA expression in human thymocytes

1989 • 36 citations

Cholesterol and serotonin transporter polymorphism interactions in late-life depression

2009 • 36 citations

Early-Life Conditions And Mechanisms Of Population Health Vulnerabilities

2007 • 36 citations

Can endocrine disruptors influence neuroplasticity in the aging brain?

2007 • 34 citations

Relations of caregiving stress and health depend on the health indicators used and gender

2006 • 34 citations

Allostatic Load of Men and Women in Early Middle Age

2005 • 33 citations

Salivary cortisol in unaffected twins discordant for affective disorder

2008 • 32 citations

A Canadian Multicenter Trial Assessing Memory and Executive Functions in Patients With Schizophrenia Spectrum Disorders Treated With Olanzapine

2003 • 31 citations

Job stress related to glyco‐lipid allostatic load, adiponectin and visfatin

2007 • 31 citations

The effect of dopamine partial agonists on the nicotine dependency in patients with schizophrenia

2009 • 30 citations

An angiotensin-1 converting enzyme polymorphism is associated with allostatic load mediated by C-reactive protein, interleukin-6 and cortisol

2008 • 30 citations

Interdisciplinary Research

2008 • 30 citations

Menopause, mild psychological stress and salivary cortisol: Influence of long-term hormone replacement therapy (HRT)

2006 • 30 citations

Influence of chronic lead exposure on hormone levels in developing rats

1990 • 30 citations

The Effects of Testosterone on Cognition in Elderly Men: A Review

2008 • 28 citations

A school-based strategy to assess children's environmental exposures and related health effects in economically disadvantaged urban neighborhoods

2000 • 28 citations

Analysis of Behavioral Disturbances Among Community-Dwelling Elderly With Alzheimer Disease

2000 • 28 citations

Lead remediation and changes in human lead exposure: some physiological and biokinetic dimensions

2003 • 26 citations

Longitudinal study of the mental health of caregivers caring for elderly patients with dementia: Effect of institutional placement on mental health

1997 • 26 citations

Ontogenic development of murine fetal thymocytes is accelerated by 3,3′,4,4′-tetrachlorobiphenyl

1993 • 25 citations

Partial androgen deficiency and neuropsychiatric symptoms in aging men.

2005 • 25 citations

Sex Hormones, Insulin Resistance and High-Density Lipoprotein Cholesterol Levels in Children

2010 • 25 citations

The link between angiotensin-converting enzyme genotype and pulmonary artery pressure in patients with COPD

2005 • 25 citations

Hormone Replacement Therapy and Coronary Heart Disease in Women: A Review of the Evidence

2002 • 25 citations

The impact of sleep interruptions on vital measurements and chronic fatigue of female caregivers providing home care in Japan

2006 • 25 citations

Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults

2008 • 22 citations

The Need for a Transdisciplinary, Global Health Framework

2011 • 21 citations

Investigations of Vitamin D Receptor Polymorphism Affecting Workers’ Susceptibility to Lead

2004 • 21 citations

Allostatic Load in Women With and Without PTSD Symptoms

2006 • 20 citations

World Psychiatric Association perspectives on person-centered psychiatry and medicine

2010 • 20 citations

Is There Such Thing as a Schizophrenic Stomach?

2006 • 20 citations

A population-based assessment of blood lead levels in relation to inflammation

2010 • 20 citations

Bone-marrow derived progenitor cells are associated with psychosocial determinants of health after controlling for classical biological and behavioral cardiovascular risk factors

2008 • 18 citations

Personality traits in unaffected twins discordant for affective disorder

2006 • 17 citations

Serum androgen levels and their association to depression and Alzheimer dementia in a cohort of 75-year-old men over 5 years: results of the VITA study

2009 • 17 citations

Self-Conscious Emotions, General Emotional Distress, and Expressed Emotion in Family Members of Patients With Schizophrenia

2010 • 15 citations

Peripheral biomarker composite associated with smaller hippocampal volume

2008 • 14 citations

Stress, health and ageing: a focus on postmenopausal women

2008 • 12 citations

Sleep disruptions and mental health of primary caregivers of persons with disability due to chronic mental and physical conditions in the Australian population

2008 • 3 citations

Deleted Work

1955 • 0 citations