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Effects of stress throughout the lifespan on the brain, behaviour and cognition

Data up to Jan 2025

Published2009
Citations5,509
References142

Total Citations Per Year

Abstract

References (142)

Epigenetic programming by maternal behavior

2004 • 5,974 citations

The Emotional Brain: The Mysterious Underpinnings of Emotional Life

2004 • 4,130 citations

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

2009 • 3,349 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Why do many psychiatric disorders emerge during adolescence?

2008 • 2,756 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Regional Development of the Brain in Early Life

1968 • 2,076 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2000 • 1,925 citations

Epidemiology of women and depression

2003 • 1,909 citations

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

1998 • 1,613 citations

The link between childhood trauma and depression: Insights from HPA axis studies in humans

2008 • 1,594 citations

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

2002 • 1,579 citations

Adolescent Brain Development: A Period of Vulnerabilities and Opportunities. Keynote Address

2004 • 1,530 citations

Hippocampal Volume and Depression: A Meta-Analysis of MRI Studies

2004 • 1,491 citations

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

1997 • 1,468 citations

Trajectories of brain development: point of vulnerability or window of opportunity?

2003 • 1,422 citations

Persistent organic pollutants (POPs): state of the science

1999 • 1,395 citations

The Environment of Poverty: Multiple Stressor Exposure, Psychophysiological Stress, and Socioemotional Adjustment

2002 • 1,183 citations

A new view on hypocortisolism

2005 • 1,147 citations

Depression and cortisol responses to psychological stress: A meta-analysis

2005 • 1,122 citations

Social regulation of the cortisol levels in early human development

2002 • 1,043 citations

Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18

1996 • 1,036 citations

Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus

2000 • 1,022 citations

The acute effects of corticosteroids on cognition: integration of animal and human model studies

1997 • 1,019 citations

A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up

2007 • 1,016 citations

Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models

2001 • 993 citations

Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.

1999 • 964 citations

Stress, sensitive periods and maturational events in adolescent depression

2008 • 908 citations

Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors

1995 • 849 citations

Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load

2001 • 836 citations

HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender

2003 • 821 citations

Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression

2002 • 798 citations

Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

1997 • 768 citations

Repeated stress causes reversible impairments of spatial memory performance

1994 • 760 citations

Early Child Care and Children’s Development Prior to School Entry: Results from the NICHD Study of Early Child Care

2002 • 731 citations

Volumetry of Hippocampus and Amygdala with High-resolution MRI and Three-dimensional Analysis Software: Minimizing the Discrepancies between Laboratories

2000 • 714 citations

The Emotional Brain: The Mysterious Underpinnings of Emotional Life

2000 • 706 citations

Pathophysiological Basis of Vulnerability to Drug Abuse: Role of an Interaction Between Stress, Glucocorticoids, and Dopaminergic Neurons

1996 • 671 citations

Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

1992 • 671 citations

Glucocorticoids and the regulation of memory consolidation

2000 • 667 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

1998 • 651 citations

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus

2003 • 641 citations

Effects of adverse experiences for brain structure and function

2000 • 638 citations

Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala

2005 • 627 citations

Developmental changes in hypothalamus–pituitary–adrenal activity over the transition to adolescence: Normative changes and associations with puberty

2009 • 626 citations

Cortisol and post-traumatic stress disorder in adults

2007 • 624 citations

Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress

1996 • 611 citations

Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy.

1999 • 596 citations

Stress hormones and human memory function across the lifespan

2004 • 545 citations

Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy.

1999 • 541 citations

Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state

2000 • 540 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus

1990 • 505 citations

Social Deprivation of Neonatal, Adolescent, and Adult Rats Has Distinct Neurochemical and Behavioral Consequences

1998 • 503 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

Psychological distress in pregnancy and preterm delivery.

1993 • 459 citations

Prenatal Anxiety Predicts Individual Differences in Cortisol in Pre-Adolescent Children

2005 • 452 citations

A randomized controlled trial of prednisone in Alzheimer’s disease

2000 • 452 citations

Brief Uncontrollable Stress Causes Dendritic Retraction in Infralimbic Cortex and Resistance to Fear Extinction in Mice

2006 • 450 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

INDUCTION OF CORTICOTROPIN-RELEASING HORMONE GENE EXPRESSION BY GLUCOCORTICOIDS: IMPLICATION FOR UNDERSTANDING THE STATES OF FEAR AND ANXIETY AND ALLOSTATIC LOAD

1998 • 422 citations

Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei

2006 • 420 citations

Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention

2004 • 414 citations

Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy

2008 • 390 citations

Regional Frontal Cortical Volumes Decrease Differentially in Aging: An MRI Study to Compare Volumetric Approaches and Voxel-Based Morphometry

2002 • 387 citations

Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable?

2006 • 383 citations

Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies

2005 • 374 citations

Long‐term effects of prenatal stress and postnatal handling on age‐related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat

1999 • 368 citations

Chronic stress: Implications for neuronal morphology, function and neurogenesis

2007 • 367 citations

HPA function in adolescence: Role of sex hormones in its regulation and the enduring consequences of exposure to stressors

2006 • 353 citations

The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa

1994 • 341 citations

The Dexamethasone/Corticotropin-Releasing Factor Test in Men with Major Depression: Role of Childhood Trauma

2007 • 338 citations

Delayed effects of chronic variable stress during peripubertal‐juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats

2004 • 334 citations

Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood

2005 • 318 citations

Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender

1999 • 291 citations

Stress History and Pubertal Development Interact to Shape Hypothalamic-Pituitary-Adrenal Axis Plasticity

2006 • 286 citations

Maternal Depressive Symptoms and the Risk of Poor Pregnancy Outcome

1995 • 281 citations

Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy

2006 • 275 citations

Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

2008 • 259 citations

Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers

1992 • 258 citations

Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation

2002 • 254 citations

The impact of early adverse care on HPA axis development: Nonhuman primate models

2006 • 247 citations

Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction

2007 • 238 citations

Stress-Induced Dendritic Remodeling in the Prefrontal Cortex is Circuit Specific

2009 • 237 citations

Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids

2007 • 237 citations

Prenatal stress and children's cortisol reaction to the first day of school

2005 • 232 citations

Hippocampal growth and attrition in birds affected by experience.

1994 • 229 citations

Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability

2007 • 228 citations

Follow‐up Study from Birth of the Effects of Prenatal Stresses

1973 • 226 citations

Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain

2006 • 225 citations

Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study

1995 • 224 citations

Effect of Acute Stress on Hippocampal Glutamate Levels and Spectrin Proteolysis in Young and Aged Rats

1995 • 219 citations

Disturbances in Morning Cortisol Secretion in Association with Maternal Postnatal Depression Predict Subsequent Depressive Symptomatology in Adolescents

2006 • 218 citations

Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat

2005 • 217 citations

Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects

2006 • 217 citations

Age of traumatisation as a predictor of post-traumatic stress disorder or major depression in young women

2004 • 216 citations

Relationship of Lead, Mercury, Mirex, Dichlorodiphenyldichloroethylene, Hexachlorobenzene, and Polychlorinated Biphenyls to Timing of Menarche Among Akwesasne Mohawk Girls

2005 • 207 citations

Maternal behavior predicts infant cortisol recovery from a mild everyday stressor

2007 • 206 citations

Cerebrospinal Fluid Corticotropin-Releasing Factor and Perceived Early-Life Stress in Depressed Patients and Healthy Control Subjects

2003 • 203 citations

Postweaning Development of Negative Feedback in the Pituitary-Adrenal System of the Rat

1973 • 200 citations

Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces

1995 • 200 citations

Maternal Care Modulates the Relationship between Prenatal Risk and Hippocampal Volume in Women But Not in Men

2007 • 187 citations

Brain and behavior interface: Stress and the developing brain

2003 • 187 citations

Alterations in diurnal cortisol rhythm and acoustic startle response in nonhuman primates with adverse rearing

2005 • 175 citations

Circadian Rhythm of Salivary Cortisol in Holocaust Survivors With and Without PTSD

2005 • 175 citations

Sleep Disturbance in Adults With Posttraumatic Stress Disorder

2007 • 167 citations

Hippocampal volume is as variable in young as in older adults: Implications for the notion of hippocampal atrophy in humans

2006 • 157 citations

Uncertainties for Endocrine Disrupters: Our View on Progress

2003 • 150 citations

Age-related differences in glucocorticoid receptor mRNA levels in the human brain

2006 • 147 citations

The foetal and infant origins of inequalities in health in Britain

1991 • 145 citations

Pituitary-Adrenal Response to Ether Vapor in the Weanling Animal: Characterization of the Inhibitory Effect of Glucocorticoids on Adrenocorticotropin Secretion

1993 • 144 citations

A New Glucocorticoid Hypothesis of Brain Aging: Implications for Alzheimers Disease

2007 • 144 citations

Depression and the Parenting of Young Children: Making the Case for Early Preventive Mental Health Services

2000 • 143 citations

Early adrenalectomy stimulates subsequent growth and development of the rat brain

1983 • 135 citations

Cortical thickness of the frontopolar area in typically developing children and adolescents

2004 • 132 citations

Learning under stress in the adult rat is differentially affected by ‘juvenile’ or ‘adolescent’ stress

2005 • 132 citations

Maternal dexamethasone treatment in late gestation alters glucocorticoid and mineralocorticoid receptor mRNA in the fetal guinea pig brain

1999 • 127 citations

From circadian rhythms to clock genes in depression

2007 • 116 citations

Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD

2005 • 109 citations

Stress during adolescence enhances locomotor sensitization to nicotine in adulthood in female, but not male, rats

2004 • 109 citations

Corticosteroid status influences the volume of the rat cingulate cortex – a magnetic resonance imaging study

2005 • 106 citations

Altered circadian cortisol secretion in Alzheimer's disease: Clinical and neuroradiological aspects

2001 • 106 citations

Psychoendocrine aspects of mother-infant relationships in nonhuman primates

1988 • 104 citations

Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children

2007 • 96 citations

Right frontal EEG asymmetry and lack of empathy in preschool children of depressed mothers.

2000 • 94 citations

Effects of Chronic Glucocorticoid Administration on Insulin-Degrading Enzyme and Amyloid-Beta Peptide in the Aged Macaque

2005 • 93 citations

Daycare Attendance, Stress, and Mental Health

2006 • 92 citations

Corticosterone alters N-methyl-d-aspartate receptor subunit mRNA expression before puberty

2003 • 83 citations

The ontogeny of brain receptors for corticotropin-releasing factor and the development of their functional association with adenylate cyclase

1988 • 79 citations

Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles

2003 • 78 citations

Stress during adolescence alters behavioral sensitization to amphetamine

2002 • 76 citations

Childhood sexual abuse and early menarche: The direction of their relationship and its implications

2005 • 74 citations

Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques

2002 • 74 citations

Glucocorticoid receptors and β-adrenoceptors in basolateral amygdala modulate synaptic plasticity in hippocampal dentate gyrus, but not in area CA1

2006 • 67 citations

Effects of social deprivation in prepubescent rhesus monkeys: immunohistochemical analysis of the neurofilament protein triplet in the hippocampal formation

1993 • 66 citations

Effects of Self‐Esteem on Age‐Related Changes in Cognition and the Regulation of the Hypothalamic‐Pituitary‐Adrenal Axis

2004 • 49 citations

Effects of prenatal maternal stress on the pituitary adrenocortical reactivity in guinea-pig pups.

1986 • 49 citations

Glucocorticoid hormone (cortisol) affects axonal transport in human cortex neurons but shows resistance in Alzheimer's disease

2004 • 46 citations

Who cares for a stressed brain? The mother, the kid or both?

2003 • 45 citations

Hypothalamic‐Pituitary‐Adrenal Axis Regulation and Human Aginga

1994 • 43 citations

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