The metabolic consequences of sleep deprivation

Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite

2004 • 2,291 citations

Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index

2004 • 2,277 citations

Early life risk factors for obesity in childhood: cohort study

2005 • 1,671 citations

Mortality Associated With Sleep Duration and Insomnia

2002 • 1,606 citations

Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance

2002 • 1,276 citations

A role for lateral hypothalamic orexin neurons in reward seeking

2005 • 1,266 citations

Short Sleep Duration as a Risk Factor for Hypertension

2006 • 1,191 citations

Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin

2004 • 1,186 citations

Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes

2005 • 1,147 citations

A Prospective Study of Sleep Duration and Coronary Heart Disease in Women

2003 • 1,120 citations

Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk

2004 • 1,107 citations

Sleep-Disordered Breathing, Glucose Intolerance, and Insulin Resistance: The Sleep Heart Health Study

2004 • 1,062 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity

2000 • 1,022 citations

Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines

2004 • 977 citations

Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin

2004 • 967 citations

Inadequate Sleep as a Risk Factor for Obesity: Analyses of the NHANES I

2005 • 896 citations

A Prospective Study of Self-Reported Sleep Duration and Incident Diabetes in Women

2003 • 879 citations

An Instrument to Measure Functional Status Outcomes for Disorders of Excessive Sleepiness

1997 • 860 citations

Sleep Duration as a Risk Factor for the Development of Type 2 Diabetes

2006 • 775 citations

Interindividual Variation in Posture Allocation: Possible Role in Human Obesity

2005 • 707 citations

The Association Between Short Sleep Duration and Obesity in Young Adults: a 13-Year Prospective Study

2004 • 667 citations

Short and Long Sleep and Sleeping Pills

1979 • 663 citations

A Prospective Study of Sleep Duration and Mortality Risk in Women

2004 • 652 citations

Role of Sleep Duration and Quality in the Risk and Severity of Type 2 Diabetes Mellitus

2006 • 624 citations

Association between Reduced Sleep and Weight Gain in Women

2006 • 609 citations

Functional neuroimaging of normal human sleep by positron emission tomography

2000 • 569 citations

Risk factors for childhood overweight: A prospective study from birth to 9.5 years

2004 • 567 citations

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation*

1997 • 550 citations

Functional neuroimaging of normal human sleep by positron emission tomography

2000 • 512 citations

Accurate Assessment of β-Cell Function

2002 • 496 citations

Short Sleep Duration is Associated with Reduced Leptin Levels and Increased Adiposity: Results from the Québec Family Study*

2007 • 486 citations

Circadian Interleukin-6 Secretion and Quantity and Depth of Sleep

1999 • 464 citations

Is obesity associated with poor sleep quality in adolescents?

2002 • 436 citations

Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.

1991 • 429 citations

Entrainment of the diurnal rhythm of plasma leptin to meal timing.

1997 • 428 citations

A dose–response relationship between short sleeping hours and childhood obesity: results of the Toyama Birth Cohort Study

2002 • 417 citations

Overweight and Obese Patients in a Primary Care Population Report Less Sleep Than Patients With a Normal Body Mass Index

2005 • 414 citations

Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes

2006 • 400 citations

Leptin increases uncoupling protein expression and energy expenditure

1997 • 396 citations

High Incidence of Diabetes in Men With Sleep Complaints or Short Sleep Duration

2005 • 379 citations

Relationship between short sleeping hours and childhood overweight/obesity: results from the ‘Québec en Forme’ Project

2006 • 371 citations

Time spent watching television, sleep duration and obesity in adults living in Valencia, Spain

2000 • 370 citations

Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones

2002 • 369 citations

The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

2002 • 344 citations

Sleep Deprivation in the Rat: An Update of the 1989 Paper

2002 • 339 citations

Sleep Deprivation in the Rat: III. Total Sleep Deprivation

1989 • 334 citations

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

2006 • 319 citations

Role of physical activity in preventing and treating obesity

2005 • 318 citations

Incidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances

2004 • 317 citations

Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep—a cross-sectional study

2002 • 306 citations

Long sleep and mortality: rationale for sleep restriction

2004 • 305 citations

Human regional cerebral glucose metabolism during non‐rapid eye movement sleep in relation to waking

2002 • 289 citations

Risk factors of obesity in a five year old population. Parental versus environmental factors.

1992 • 277 citations

Pattern and intensity of physical activity

2001 • 269 citations

Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis

2005 • 261 citations

Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

2003 • 260 citations

Energy Homeostasis, Obesity and Eating Disorders: Recent Advances in Endocrinology

2004 • 259 citations

Relationship Between Sleepiness and General Health Status

1996 • 254 citations

Sleep deprivation in the rat by the disk-over-water method

1995 • 243 citations

Sleep disturbance as a predictor of type 2 diabetes mellitus in men and women from the general population

2005 • 233 citations

Sex Differences in the Association between Sleep and Body Mass Index in Adolescents

2005 • 224 citations

Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats

2004 • 223 citations

Sleep Duration and Body Mass Index in a Rural Population

2006 • 216 citations

Circadian and Ultradian Variations of Leptin in Normal Man under Continuous Enteral Nutrition: Relationship to Sleep and Body Temperature

1998 • 212 citations

Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats

2004 • 208 citations

Minimal Model: Perspective from 2005

2005 • 205 citations

Weekly Subcutaneous Pegylated Recombinant Native Human Leptin (PEG-OB) Administration in Obese Men

2000 • 201 citations

Orexin and MCH neurons express c‐Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors

2005 • 195 citations

Cost-of-Illness Studies in Diabetes Mellitus

2004 • 194 citations

Sleep enhances nocturnal plasma ghrelin levels in healthy subjects

2004 • 185 citations

The Association Between Obesity and Short Sleep Duration: A Population-Based Study

2005 • 183 citations

Adaptation of the 24-h growth hormone profile to a state of sleep debt

2000 • 175 citations

Determinants of total daily energy expenditure: variability in physical activity

1994 • 170 citations

The Influence of Lifestyle and Health Status Factors on Sleep Loss Among the Japanese General Population

2001 • 161 citations

Sleep Disturbances in Midlife Unrelated to 32-Year Diabetes Incidence

2005 • 158 citations

Dependence of sleep on nutrients' availability

1979 • 156 citations

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

1997 • 153 citations

Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue

2005 • 149 citations

Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers

1994 • 142 citations

Relationships between sleep quality and glucose regulation in normal humans

1996 • 137 citations

Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men

2001 • 123 citations

Effects of sleep deprivation and exercise on glucose tolerance.

1993 • 116 citations

Persistence of the circadian thyrotropin rhythm under constant conditions and after light-induced shifts of circadian phase.

1994 • 115 citations

An Epidemiological Study on Relationship between the Hours of Sleep and Life Style Factors in Japanese Factory Workers.

2002 • 114 citations

Physiology, stress, and malnutrition : functional correlates, nutritional intervention

1997 • 101 citations

Circadian Interleukin-6 Secretion and Quantity and Depth of Sleep

1999 • 100 citations

Validity of Child Sleep Diary Questionnaire among Junior High School Children

2004 • 99 citations

Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones

2002 • 94 citations

Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men

2003 • 91 citations

Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention

2006 • 84 citations

Environmental factors associated with body mass index in a population of Southern France

2004 • 83 citations

The Effects of Leptin Administration in Non‐obese Human Subjects

2001 • 81 citations

Circadian and Ultradian Variations of Leptin in Normal Man under Continuous Enteral Nutrition: Relationship to Sleep and Body Temperature

1998 • 56 citations

Weekly Subcutaneous Pegylated Recombinant Native Human Leptin (PEG-OB) Administration in Obese Men

2000 • 48 citations

Sleep Deprivation

2004 • 44 citations

Persistence of the circadian thyrotropin rhythm under constant conditions and after light-induced shifts of circadian phase

1994 • 42 citations

Glucose Metabolism in Older Adults: A Study Including Subjects More Than 80 Years of Age

1997 • 34 citations

Genetic Mapping of Disposition Index and Acute Insulin Response Loci on Chromosome 11q

2006 • 34 citations

Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects

1995 • 31 citations

Metabolic and Endocrine Changes

2004 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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