H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Antipsychotic-Induced Weight Gain: A Comprehensive Research Synthesis

1999 • 2,382 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia

1999 • 1,012 citations

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

1997 • 985 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

The Role of Serotonin in Antipsychotic Drug Action

1999 • 672 citations

Evidence for Possible Involvement of 5-HT _2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

2000 • 668 citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1994 • 592 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials

2003 • 472 citations

Reduction of suicidality during clozapine treatment of neuroleptic- resistant schizophrenia: impact on risk-benefit assessment

1995 • 446 citations

Atypical antipsychotics and weightgain — a systematic review

2000 • 410 citations

Association of antipsychotic druginduced weight gain with a 5-HT2C receptor gene polymorphism

2002 • 405 citations

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

2001 • 373 citations

Discovery of a Novel Member of the Histamine Receptor Family

2001 • 357 citations

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

1999 • 290 citations

Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells.

1992 • 271 citations

Antipsychotic Metabolic Effects: Weight Gain, Diabetes Mellitus, and Lipid Abnormalities

2001 • 262 citations

Bodyweight Gain with Atypical Antipsychotics

2001 • 235 citations

Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors

1997 • 235 citations

Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate

2001 • 233 citations

Identification, Expression, and Pharmacology of a Cys23-Ser23 Substitution in the Human 5-HT2C Receptor Gene (HTR2C)

1995 • 223 citations

Advances in pharmacology

1999 • 209 citations

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.

1992 • 192 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

2000 • 169 citations

2-Substituted Tryptamines: Agents with Selectivity for 5-HT₆Serotonin Receptors

2000 • 147 citations

Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

2001 • 141 citations

Dr. Meltzer and Mr. Cola Reply

1995 • 137 citations

Targeted Disruption of Histamine H1-Receptor Attenuates Regulatory Effects of Leptin on Feeding, Adiposity, and UCP Family in Mice

2001 • 137 citations

Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation

1988 • 134 citations

Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice

2001 • 119 citations

Neuronal histamine modulates feeding behavior through H1-receptor in rat hypothalamus

1989 • 116 citations

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

2001 • 99 citations

Muscarinic m4 receptor activation by some atypical antipsychotic drugs

1997 • 93 citations

Manipulation of Central Nervous System Histamine or Histaminergic Receptors (H1) Affects Food Intake in Rats

1994 • 79 citations

Antipsychotic‐induced weight gain

2004 • 79 citations

Suicide and Schizophrenia: Clozapine and the InterSePT Study

1999 • 57 citations

Low-dose loxapine in the treatment of schizophrenia: is it more effective and more "atypical" than standard-dose loxapine?

1999 • 53 citations

Suicide and schizophrenia: clozapine and the InterSePT study. International Clozaril/Leponex Suicide Prevention Trial.

1999 • 48 citations

Binding of Typical and Atypical Antipsychotic Drugs to Multiple Neurotransmitter Receptors

1997 • 45 citations

Efficacy and tolerability of fluoxetine in the elderly: a double-blind study versus amitryptiline.

1989 • 29 citations

Long-term depletion of brain histamine induced by α-fluoromethylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels

1995 • 25 citations

A Beautiful Mind

1999 • 24 citations

Differential effects of psychotropic drugs on feeding in rats: Is histamine blockade involved?

1990 • 22 citations

Effect of thiazol-4-ylmethoxyamine, a new inhibitor of histamine biosynthesis on brain histamine, monoamine levels and behavior

1971 • 18 citations