Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

2003 • 8,039 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Neurobiology of Depression

2002 • 3,057 citations

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

2001 • 2,667 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2000 • 1,925 citations

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

1993 • 1,626 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat

1998 • 1,410 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1990 • 1,362 citations

A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression

2000 • 1,296 citations

Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report

1997 • 1,264 citations

Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey

2001 • 1,197 citations

Physiology and pharmacology of corticotropin-releasing factor.

1991 • 1,138 citations

Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment

2003 • 1,115 citations

The long-term impact of the physical, emotional, and sexual abuse of children: A community study

1996 • 1,018 citations

Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models

2001 • 993 citations

Toward a Comprehensive Developmental Model for Major Depression in Women

2002 • 934 citations

Hippocampal volume in women victimized by childhood sexual abuse

1997 • 919 citations

Clinical Characteristics of Women With a History of Childhood Abuse

1997 • 915 citations

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

1996 • 883 citations

Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma

2003 • 805 citations

Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression

2002 • 798 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse

2001 • 733 citations

Long-term behavioral and neuroendocrine adaptations to adverse early experience

2000 • 707 citations

Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder

1999 • 682 citations

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

1994 • 657 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Regional Cerebral Blood Flow During Script-Driven Imagery in Childhood Sexual Abuse-Related PTSD: A PET Investigation

1999 • 644 citations

Corticotropin-releasing factor, norepinephrine, and stress

1999 • 623 citations

DSM-III and the transformation of American psychiatry: a history

1993 • 612 citations

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

2000 • 594 citations

Developmental neurobiology of childhood stress and trauma

2002 • 577 citations

Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia

1999 • 570 citations

The prediction of major depression in women: toward an integrated etiologic model

1993 • 564 citations

Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates

1999 • 516 citations

Effects of early adverse experiences on brain structure and function: clinical implications

2000 • 509 citations

Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment

2001 • 504 citations

Current status of cortisol findings in post-traumatic stress disorder

2002 • 500 citations

Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular Nucleus

2000 • 446 citations

Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences

2002 • 403 citations

Childhood Parental Loss and Adult Psychopathology in Women

1992 • 401 citations

Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression

1995 • 398 citations

Depressive Disorders: Toward a Unified Hypothesis

1973 • 392 citations

Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats

2002 • 375 citations

Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption.

1991 • 375 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

Classifying Depression: Should Paradigms Lost Be Regained?

2000 • 338 citations

Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse

2002 • 277 citations

Relationship of childhood maltreatment to the onset and course of major depression in adulthood

1999 • 269 citations

Treatment for chronic depression using Cognitive Behavioral Analysis System of Psychotherapy (CBASP)

2003 • 267 citations

The Corticotropin-Releasing Hormone Challenge in Depressed Abused, Depressed Nonabused, and Normal Control Children

1997 • 263 citations

A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys

1992 • 243 citations

Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress

2001 • 239 citations

Asymmetric Frontal Brain Activity, Cortisol, and Behavior Associated with Fearful Temperament in Rhesus Monkeys

2002 • 234 citations

In vivo neurogenesis in the adult brain: regulation and functional implications

2000 • 212 citations

Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia

2000 • 207 citations

Early and late onset depression in old age: different aetiologies, same phenomenology

2001 • 200 citations

Childhood Attachment and Loss Experiences Affect Adult Cardiovascular and Cortisol Function

1998 • 186 citations

Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates

1994 • 181 citations

Early experience and depressive disorders: human and non-human primate studies

2003 • 164 citations

Rearing Experiences and Stress-Induced Plasma Cortisol as Early Risk Factors for Excessive Alcohol Consumption in Nonhuman Primates

2000 • 157 citations

Environmental stress and psychiatric illness

2000 • 154 citations

Social rearing effects on HPA axis activity over early development and in response to stress in rhesus monkeys

1993 • 143 citations

The biology of human parenting: insights from nonhuman primates

1999 • 143 citations

Childhood adversity and vulnerability to mood and anxiety disorders.

1997 • 139 citations

Repeated parental deprivation in the infant common marmoset (callithrix jacchus, primates) and analysis of its effects on early development

2002 • 135 citations

Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

2003 • 135 citations

Childhood Emotional Trauma and Chronic Posttraumatic Stress Disorder in Adult Outpatients with Treatment-Resistant Depression

2000 • 128 citations

Lower Cortisol Levels in Depressed Patients with Comorbid Post-Traumatic Stress Disorder

2002 • 118 citations

Neural correlates of maternal separation in rhesus monkeys

2001 • 108 citations

Outcome of Dysthymic Disorder at 5-Year Follow-Up: The Effect of Familial Psychopathology, Early Adversity, Personality, Comorbidity, and Chronic Stress

2001 • 106 citations

Childhood adversity and vulnerability to mood and anxiety disorders

1997 • 105 citations

Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats

2001 • 99 citations

Early Life Stress: Long-Term Physiological Impact in Rodents and Primates

2002 • 95 citations

Response of adolescent bonnet macaques to an acute fear stimulus as a function of early rearing conditions

2001 • 70 citations

Early Environmental Regulation of Glucocorticoid Feedback Sensitivity in Young Adult Monkeys

2000 • 65 citations

Fluvoxamine Reduces Responsiveness of HPA Axis in Adult Female BPD Patients with a History of Sustained Childhood Abuse

2003 • 64 citations

Neurobiology of Early-Life Stress

2003 • 60 citations

Psychosocial predictors of the short-term course and outcome of major depression: A longitudinal study of a nonclinical sample with recent-onset episodes.

2000 • 58 citations

Postnatal Experiences and Genetic Effects on Squirrel Monkey Social Affinities and Emotional Distress

1999 • 48 citations

Psychosocial predictors of the short-term course and outcome of major depression: A longitudinal study of a nonclinical sample with recent-onset episodes.

2000 • 45 citations

Cerebrospinal Fluid Corticotropin-Releasing Factor (CRF) and Vasopressin Concentrations Predict Pituitary Response in the CRF Stimulation Test: A Multiple Regression Analysis

2002 • 45 citations

Depression Sub-Typing: Unitary, Binary or Arbitrary?

1991 • 20 citations