Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis

The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia

1987 • 19,723 citations

ECDEU Assessment Manual for Psychopharmacology

1976 • 8,729 citations

A review of MRI findings in schizophrenia

2001 • 2,310 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

The neuropathology of schizophrenia

1999 • 1,664 citations

Dynamics of Gray Matter Loss in Alzheimer's Disease

2003 • 1,088 citations

Automated model-based tissue classification of MR images of the brain

1999 • 1,020 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

Brain abnormality in schizophrenia

1998 • 859 citations

Catching Up on Schizophrenia

2000 • 815 citations

MRI anatomy of schizophrenia

1999 • 735 citations

Longitudinal study of brain morphology in first episode schizophrenia

2001 • 558 citations

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

1998 • 542 citations

Progressive Structural Brain Abnormalities and Their Relationship to Clinical Outcome

2003 • 539 citations

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

1997 • 517 citations

Is schizophrenia a neurodegenerative disorder? a clinical and neurobiological perspective

1999 • 476 citations

Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men

2001 • 417 citations

Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism

1998 • 413 citations

Comparative Efficacy and Safety of Atypical and Conventional Antipsychotic Drugs in First-Episode Psychosis: A Randomized, Double-Blind Trial of Olanzapine Versus Haloperidol

2003 • 401 citations

Brain Volume Changes in First-Episode Schizophrenia

2002 • 397 citations

Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

1999 • 383 citations

Comparative Effect of Atypical and Conventional Antipsychotic Drugs on Neurocognition in First-Episode Psychosis: A Randomized, Double-Blind Trial of Olanzapine Versus Low Doses of Haloperidol

2004 • 310 citations

Change in Basal Ganglia Volume Over 2 Years in Patients With Schizophrenia: Typical Versus Atypical Neuroleptics

1999 • 259 citations

Expression of brain‐derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs

2002 • 239 citations

Atypical neuroleptics stimulate neurogenesis in adult rat brain

2002 • 232 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia

2001 • 195 citations

Effects of Chronic Haloperidol and Clozapine Treatment on Neurogenesis in the Adult Rat Hippocampus

2004 • 190 citations

Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure

1999 • 169 citations

Effects of Antipsychotic Drugs on Neurogenesis in the Forebrain of the Adult Rat

2004 • 165 citations

A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia

2001 • 153 citations

Induction of NF-κB Activity during Haloperidol-Induced Oxidative Toxicity in Clonal Hippocampal Cells: Suppression of NF-κB and Neuroprotection by Antioxidants

1998 • 153 citations

Olanzapine and Clozapine Increase the GABAergic Neuroactive Steroid Allopregnanolone in Rodents

2003 • 142 citations

The effects of haloperidol on synaptic patterns in the rat striatum

1985 • 127 citations

Effect of Antipsychotics on Regional Cerebral Blood Flow Measured with Positron Emission Tomography

1997 • 105 citations

Striatal enlargement in rats chronically treated with neuroleptic

1998 • 100 citations

Comparison of the effects of clozapine, risperidone, and olanzapine on ketamine-induced alterations in regional brain metabolism.

2000 • 92 citations

Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia

1998 • 83 citations

Clozapine but not Haloperidol Re-establishes Normal Task-Activated rCBF Patterns in Schizophrenia within the Anterior Cingulate Cortex

2003 • 80 citations

Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex

2001 • 80 citations

Effect of antipsychotic drugs on brain‐derived neurotrophic factor expression under reduced N‐methyl‐D‐aspartate receptor activity

2003 • 74 citations

Structural Brain MRI Abnormalities in Healthy Siblings of Patients With Childhood-Onset Schizophrenia

2003 • 72 citations

Effect of haloperidol and clozapine on the density of “perforated” synapses in caudate, nucleus accumbens, and medial prefrontal cortex

1992 • 63 citations

Multisite validation of image analysis methods: assessing intra- and intersite variability

2002 • 56 citations

Tardive dyskinesia and substrates of energy metabolism in CSF

1995 • 50 citations

Cerebral metabolism and risperidone treatment in schizophrenia

2002 • 46 citations

The Brain Metabolic Patterns of Clozapine- and Fluphenazine-Treated Female Patients with Schizophrenia Evidence of a Sex Effect

1999 • 25 citations