Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

1993 • 486 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

1999 • 293 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

Stimulation of V(D)J cleavage by high mobility group proteins

1997 • 256 citations

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

1999 • 251 citations

RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with the RAD51 protein

1997 • 236 citations

Activation changes the spectrum but not the diversity of genes expressed by T cells

1999 • 227 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis

2000 • 164 citations

Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages

1999 • 141 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double-deficient mice

2000 • 127 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals

1997 • 110 citations

Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation

1998 • 87 citations

CD2 Regulates the Positive Selection and Function of Antigen-Specific CD4−CD8+ T Cells

1997 • 80 citations

An Essential Role for the IL-7 Receptor During Intrathymic Expansion of the Positively Selected Neonatal T Cell Repertoire

2000 • 73 citations

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

1995 • 72 citations

Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development

2001 • 64 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.

1995 • 62 citations

Transgenic analysis of thymocyte signal transduction

2002 • 57 citations

The Winged-Helix Transcription Factor Trident is Expressed in Actively Dividing Lymphocytes

1997 • 51 citations

Modulation of Thymic Selection by Expression of an Immediate-early Gene, Early Growth Response 1 (Egr-1)

1998 • 50 citations

Identification of a Developmentally Regulated Phase of Postselection Expansion Driven by Thymic Epithelium

1998 • 46 citations

Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation

2001 • 44 citations

Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.

2001 • 41 citations

The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection

1996 • 40 citations

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

1999 • 39 citations

Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.

1994 • 38 citations

Distribution and ontogeny of CD2 expression by murine T cells.

1989 • 37 citations

Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.

1997 • 36 citations

Expression of an avian CD6 candidate is restricted to αβ T cells, splenic CD8⁺ γδ T cells and embryonic natural killer cells

1996 • 34 citations

Characterization of mouse CD53: Epitope mapping, cellular distribution and induction by T cell receptor engagement during repertoire selection

1995 • 31 citations

Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.

1995 • 27 citations

The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection

1996 • 26 citations

Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny.

1995 • 26 citations

A role for c-myc in the regulation of thymocyte differentiation and possibly positive selection.

1996 • 25 citations

Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells

2000 • 24 citations

Characterization of lymphoid tumors induced by a recombinant murine retrovirus carrying the avian v-myc oncogene. Identification of novel (B-lymphoid) tumors in the thymus.

1988 • 24 citations

Developmental Regulation of Lymphocyte-Specific Protein 1 (LSP1) Expression in Thymus During Human T-Cell Maturation

1998 • 15 citations

Organization of the gene encoding the mouse T-cell-specific serine proteinase “granzyme A”

1992 • 14 citations

A T lymphoid cell line responds to a thymic stromal cell line by expression of Thy-1 and CD4.

1989 • 13 citations

Regulation of expression of TL genes of the mouse Mhc

1990 • 4 citations