Positive and negative thymic selection in T cell receptor‐transgenic mice correlate with Nur77 mRNA expression

The Fas Death Factor

1995 • 4,070 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

The biochemistry of programmed cell death

1995 • 997 citations

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants

1994 • 987 citations

Fundamental Immunology

1994 • 903 citations

Negative selection of lymphocytes

1994 • 810 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Positive selection of lymphocytes

1994 • 563 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

The CTL's kiss of death

1995 • 504 citations

The natural history of the major histocompatibility complex

1987 • 500 citations

Neuroendocrine-Immune System Interactions and Autoimmunity

1995 • 460 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells

1996 • 337 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

Die and Let Live: Eliminating Dangerous Lymphocytes

1996 • 242 citations

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.

1996 • 233 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Identification of a new brain-specific transcription factor, NURR1

1992 • 229 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

A family of ligands for the TNF receptor superfamily

1994 • 128 citations

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

1996 • 126 citations

Methods for the Detection of Apoptosis

1994 • 125 citations

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

1993 • 124 citations

Glucocorticoid-induced Apoptosis of Lymphoid Cells

1994 • 122 citations

Cell-mediated cytotoxicity

1993 • 108 citations

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

1996 • 107 citations

9-cis Retinoic Acid Inhibition of Activation-Induced Apoptosis Is Mediated via Regulation of Fas Ligand and Requires Retinoic Acid Receptor and Retinoid X Receptor Activation

1995 • 105 citations

Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes

1994 • 97 citations

Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells.

1996 • 97 citations

Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.

1988 • 94 citations

Receptors and signals in early thymic selection

1995 • 90 citations

Killing of immature CD4⁺CD8⁺ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486

1993 • 79 citations

Cell differentiation in acute myeloid leukemia

1996 • 73 citations

The Role of Programmed Cell Death as an Emerging New Concept for the Pathogenesis of Autoimmune Diseases

1996 • 61 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Differential reactivity of residual CD8⁺ T lymphocytes in TAP1 and β2‐microglobulin mutant mice

1995 • 39 citations

Inhibition of I‐A^d‐, but not D^b‐restricted peptide‐induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

1996 • 36 citations

Retinoic acid modulates the in vivo and in vitro growth of IL-6 autocrine human myeloma cell lines via induction of apoptosis

1996 • 35 citations

Rhodamine 123: A useful probe for monitoring T cell activation

1995 • 33 citations

13-cis Retinoic Acid Inhibits Growth of Adult T Cell Leukemia Cells and Causes Apoptosis; Possible New Indication for Retinoid Therapy.

1996 • 30 citations

Thymocyte Apoptosis by Glucocorticoids and cAMP

1995 • 20 citations

Molecular Characterization of the Nur77 Orphan Steroid Receptor in Apoptosis

1994 • 12 citations

Inhibition of growth and induction of apoptosis by all‐trans retinoic acid in lymphoid cell lines transfected with the PML/RARα fusion gene

1996 • 12 citations

Genes that regulate apoptosis in the mouse thymus

1996 • 7 citations