Linear signaling in the Toll-Dorsal pathway ofDrosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

1999 • 635 citations

twist and snail as positive and negative regulators during Drosophila mesoderm development.

1991 • 550 citations

Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo

2001 • 378 citations

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

1991 • 361 citations

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1988 • 353 citations

twist : A Myogenic Switch in Drosophila

1996 • 325 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

1994 • 307 citations

A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity

2000 • 306 citations

Role of Drosophila IKKγ in a Toll-independent antibacterial immune response

2000 • 266 citations

Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo

1991 • 241 citations

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product

1991 • 236 citations

Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity

1998 • 208 citations

Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster.

1991 • 198 citations

Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning

1998 • 187 citations

The antibacterial arm of the Drosophila innate immune response requires an IκB kinase

2001 • 187 citations

A genomewide survey of basic helix–loop–helix factors in Drosophila

2000 • 169 citations

Dimerization partners determine the activity of the Twist bHLH protein duringDrosophilamesoderm development

2001 • 160 citations

Dorsoventral patterning in the Drosophila central nervous system: the vnd homeobox gene specifies ventral column identity

1998 • 155 citations

Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg

1992 • 154 citations

Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo

1996 • 152 citations

Convergence of Dorsal, Dpp, and Egfr Signaling Pathways Subdivides the Drosophila Neuroectoderm into Three Dorsal-Ventral Columns

2000 • 131 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

Conservation of dorsal-ventral patterning in arthropods and chordates

1996 • 116 citations

Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.

2001 • 112 citations

Getting knotted: a model for the structure and activation of Spätzle

1998 • 110 citations

Dorsal-Ventral Patterning Genes Restrict NK-2 Homeobox Gene Expression to the Ventral Half of the Central Nervous System of Drosophila Embryos

1995 • 104 citations

bicoid -Independent Formation of Thoracic Segments in Drosophila

2000 • 100 citations

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

1992 • 90 citations

The maternal NF-κB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle

2000 • 86 citations

Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

1993 • 80 citations

Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila

1994 • 79 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

An anteroposterior Dorsal gradient in theDrosophila embryo

1997 • 60 citations

Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo

1998 • 60 citations

The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo

2001 • 58 citations

Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

1997 • 56 citations

Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube

1998 • 54 citations

Developmental evolution: Axial patterning in insects

1999 • 46 citations

Specification of the Drosophila CNS midline cell lineage: direct control of single-minded transcription by dorsal/ventral patterning genes.

1998 • 45 citations

Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling

2000 • 42 citations

Developmental genetics of the gastrulation defective locus in Drosophila melanogaster

1988 • 32 citations