Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Drosophila: A laboratory handbook

1990 • 1,742 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Drosophila: A laboratory handbook

1990 • 1,243 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

1988 • 736 citations

Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

1985 • 675 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos

1988 • 346 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

A fate map for the larval epidermis ofDrosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam

1979 • 287 citations

The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal

1991 • 260 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

The nucleotide sequence and the tissue-specific expression of Drosophila c-src

1985 • 201 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation

1991 • 140 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

A Gradient of Cactus Protein Degradation Establishes Dorsoventral Polarity in theDrosophilaEmbryo

1996 • 124 citations

Distribution of F-actin during cleavage of the Drosophila syncytial blastoderm.

1984 • 120 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila

1996 • 119 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity

1992 • 112 citations

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

1996 • 102 citations

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

1997 • 102 citations

A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.

1993 • 88 citations

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.

1993 • 79 citations

Signaling, mitogenesis and the cytoskeleton: Where the action is

1995 • 76 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

Ancient relationships

1994 • 67 citations

An anteroposterior Dorsal gradient in theDrosophila embryo

1997 • 60 citations

Signalling pathways: A common theme in plants and animals?

1997 • 56 citations

Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

1993 • 42 citations

A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal

1997 • 36 citations

Developmental genetics of the gastrulation defective locus in Drosophila melanogaster

1988 • 32 citations

An early role of maternal mRNA in establishing the dorsoventral pattern in pelle mutant Drosophila embryos

1985 • 17 citations