Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

A RAPID ALKALINE EXTRACTION PROCEDURE FOR SCREENING RECOMBINANT DNA

1979 • 1,402 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Drosophila: a laboratory manual

1990 • 1,081 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Developmental genetics of oogenesis

1993 • 858 citations

Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

1985 • 675 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene product

1985 • 607 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

1993 • 567 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.

1988 • 460 citations

The drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein

1993 • 443 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.

1989 • 360 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Extension and structural variability of the antithrombin-binding sequence in heparin.

1984 • 340 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

Structure of a dermatan sulfate hexasaccharide that binds to heparin cofactor II with high affinity.

1990 • 298 citations

Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo

1997 • 294 citations

hu-li tai shao, a gene required for ring canal formation during Drosophila oogenesis, encodes a homolog of adducin.

1992 • 286 citations

Determinants of heat shock-induced chromosome puffing

1985 • 281 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal

1991 • 260 citations

Drosophila: A laboratory manual

1990 • 245 citations

The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development

1989 • 235 citations

Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation

1991 • 230 citations

cDNA selection: efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragments.

1991 • 211 citations

Intercellular signaling and the polarization of body axes during Drosophila oogenesis.

1996 • 202 citations

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos

1991 • 187 citations

Proteolytic processing of the Drosophila Spätzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity

1998 • 183 citations

The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo

1989 • 175 citations

DEVELOPMENTAL GENETICS OF THE DROSOPHILA EGG I. IDENTIFICATION OF 59 SEX-LINKED CISTRONS WITH MATERNAL EFFECTS ON EMBRYONIC DEVELOPMENT

1977 • 164 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease

1986 • 148 citations

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation

1991 • 140 citations

Molecular Cloning and Expression of Chinese Hamster Ovary Cell Heparan-sulfate 2-Sulfotransferase

1997 • 122 citations

fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology inDrosophila melanogaster

1978 • 121 citations

torso-like encodes the localized determinant of Drosophila terminal pattern formation.

1993 • 116 citations

The relationship between ovarian and embryonic dorsoventral patterning in Drosophila

1994 • 113 citations

Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity

1992 • 112 citations

An unusual mosaic protein with a protease domain, encoded by the nudeI gene, is involved in defining embryonic dorsoventral polarity in Drosophila

1995 • 109 citations

Characterization of bacteriophage P1 library containing inserts of Drosophila DNA of 75?100 kilobase pairs

1991 • 97 citations

RNA- and single-stranded DNA-binding (SSB) proteins expressed during Drosophila melanogaster oogenesis: a homolog of bacterial and eukaryotic mitochondrial SSBs

1994 • 77 citations

Purification and Characterization of Heparan Sulfate 2-Sulfotransferase from Cultured Chinese Hamster Ovary Cells

1996 • 75 citations

Localized Requirements for windbeutel and pipe Reveal a Dorsoventral Prepattern within the Follicular Epithelium of the Drosophila Ovary

1998 • 73 citations

windbeutel,a gene required for dorsoventral patterning inDrosophila,encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum

1998 • 67 citations

Thegastrulation defectivegene ofDrosophila melanogasteris a member of the serine protease superfamily

1998 • 66 citations

Extracellular proteases and embryonic pattern formation

1992 • 62 citations

Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ash1).

1994 • 50 citations

Maps of the salivary gland chromosomes of Drosophila melanogaster

1994 • 37 citations

Mechanisms of dorsal-ventral axis determination in Drosophila embryos revealed by cytoplasmic transplantations

1993 • 29 citations