Getting knotted: a model for the structure and activation of Spätzle

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

The leucine-rich repeat: a versatile binding motif

1994 • 1,209 citations

Calculating the electrostatic potential of molecules in solution: Method and error assessment

1988 • 1,096 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

A structural superfamily of growth factors containing a cystine knot motif

1993 • 529 citations

Definition of general topological equivalence in protein structures

1990 • 506 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

The SWISS-PROT protein sequence data bank and its new supplement TREMBL

1996 • 466 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

Structural and functional diversity in the leucine-rich repeat family of proteins

1996 • 311 citations

The Cystine-Knot Growth-Factor Superfamily

1995 • 281 citations

Knowledge‐based protein modelling and design

1988 • 246 citations

Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction

1990 • 215 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis

1989 • 182 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors

1993 • 155 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

Structure of the Brain-Derived Neurotrophic Factor/Neurotrophin 3 Heterodimer

1995 • 120 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

Signaling Pathways that Establish the Dorsal-Ventral Pattern of the Drosophila Embryo

1995 • 86 citations

A variable gap penalty function and feature weights for protein 3-D structure comparisons

1992 • 80 citations

Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.

1996 • 77 citations

A common domain within the proenzyme regions of the drosophila snake and easter proteins and tachypleus proclotting enzyme defines a new subfamily of serine proteases

1992 • 58 citations

Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein.

1995 • 46 citations

Regulation of translation and proteolysis during the development of embryonic dorso-ventral polarity in Drosophila

1992 • 34 citations