Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Determination of Anteroposterior Polarity in Drosophila

1987 • 651 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

twist and snail as positive and negative regulators during Drosophila mesoderm development.

1991 • 550 citations

Vectors for Drosophila P-element-mediated transformation and tissue culture transfection

1988 • 547 citations

Regulation of even-skipped stripe 2 in the Drosophila embryo.

1992 • 522 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

1991 • 361 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1988 • 353 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

MATERNAL-ZYGOTIC GENE INTERACTIONS DURING FORMATION OF THE DORSOVENTRAL PATTERN IN DROSOPHILA EMBRYOS

1983 • 338 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers

1987 • 312 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes

1991 • 257 citations

Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.

1987 • 247 citations

Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo

1991 • 241 citations

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product

1991 • 236 citations

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila

1991 • 229 citations

Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors

1991 • 224 citations

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers

1991 • 214 citations

Pattern Formation During Animal Development

1991 • 199 citations

Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila

1987 • 143 citations

Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the even-skipped homeo box protein with a distal enhancer element.

1991 • 134 citations

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.

1991 • 132 citations

Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila.

1989 • 123 citations

Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo.

1992 • 104 citations

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

1992 • 90 citations

Molecular Nature of the Drosophila Sex Determination Signal and Its Link to Neurogenesis

1991 • 86 citations

Growth factors as morphogens: do gradients and thresholds establish body plan?

1991 • 86 citations

The same dorsal binding site mediates both activation and repression in a context-dependent manner.

1992 • 76 citations

Pattern Specification in the Insect Embryo

1975 • 69 citations

Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.

1991 • 58 citations

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