Specification of the Drosophila CNS midline cell lineage: direct control of single-minded transcription by dorsal/ventral patterning genes.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

twist and snail as positive and negative regulators during Drosophila mesoderm development.

1991 • 550 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.

1988 • 471 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

1995 • 430 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.

1991 • 361 citations

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1988 • 353 citations

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1998 • 347 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers

1987 • 312 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system

1988 • 254 citations

The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells

1990 • 241 citations

Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo

1991 • 241 citations

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers

1991 • 214 citations

Expression Patterns of Two Murine Homologs ofDrosophila Single-MindedSuggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome

1996 • 198 citations

The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling

1994 • 190 citations

The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development

1997 • 185 citations

Short-range repression permits multiple enhancers to function autonomously within a complex promoter.

1994 • 159 citations

Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo

1996 • 152 citations

The interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression.

1993 • 131 citations

CNS midline enhancers of the Drosophila slit and Toll genes

1993 • 97 citations

Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation

1994 • 97 citations

Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

1995 • 92 citations

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

1992 • 90 citations

Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification

1995 • 85 citations

Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

1993 • 80 citations

The formation of commissures in the Drosophila CNS depends on the midline cells and on the Notch gene

1994 • 71 citations

The Drosophila virilis dopa decarboxylase gene is developmentally regulated when integrated into Drosophila melanogaster.

1986 • 58 citations

A Direct Contact between the Dorsal rel Homology Domain and Twist May Mediate Transcriptional Synergy

1997 • 55 citations

Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development

1994 • 41 citations

The establishment and interpretation of transcription factor gradients in the Drosophila embryo

1995 • 35 citations

Single-minded regulation of genes in the embryonic midline of the Drosophila central nervous system

1993 • 34 citations

The development and function of the Drosophila CNS midline cells

1993 • 33 citations