A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Map-Based Cloning of a Protein Kinase Gene Conferring Disease Resistance in Tomato

1993 • 1,423 citations

The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor

1994 • 1,323 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Molecular Genetics of Plant Disease Resistance

1995 • 932 citations

Isolation of the Tomato Cf-9 Gene for Resistance to Cladosporium fulvum by Transposon Tagging

1994 • 903 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

1985 • 675 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Innate immunity of insects

1995 • 549 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Immune reactions in Drosophila and other insects: a model for innate immunity

1993 • 417 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response

1995 • 386 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1993 • 322 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

Proteasomes: protein degradation machines of the cell

1994 • 320 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

A fate map for the larval epidermis ofDrosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam

1979 • 287 citations

Connectin: A homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila

1992 • 282 citations

REL/NF-κB/IκB Story

1995 • 278 citations

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

1992 • 252 citations

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.

1995 • 252 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product

1991 • 236 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

κB-like Motifs Regulate the Induction of Immune Genes in Drosophila

1993 • 229 citations

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila

1991 • 229 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6.

1993 • 192 citations

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos

1991 • 187 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus

1994 • 183 citations

Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction.

1992 • 180 citations

Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter.

1992 • 179 citations

A member of the tomato Pto gene family confers sensitivity to fenthion resulting in rapid cell death.

1994 • 178 citations

NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity

1995 • 172 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila.

1993 • 159 citations

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation

1991 • 140 citations

Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation.

1988 • 134 citations

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.

1991 • 132 citations

Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.

1993 • 127 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

The Drosophila membrane receptor Toll can function to promote cellular adhesion.

1990 • 115 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.

1995 • 109 citations

Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo.

1992 • 104 citations

The Drosophila Toll Gene Functions Zygotically and Is Necessary for Proper Motoneuron and Muscle Development

1995 • 103 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.

1994 • 103 citations

Organization and expression of the immunoresponsive lysozyme gene in the giant silk moth, Hyalophora cecropia.

1991 • 95 citations

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

1993 • 92 citations

Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila.

1993 • 89 citations

Signaling Pathways that Establish the Dorsal-Ventral Pattern of the Drosophila Embryo

1995 • 86 citations

Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

1992 • 86 citations

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.

1993 • 79 citations

Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cells

1994 • 76 citations

The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.

1992 • 71 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit.

1993 • 64 citations

Interactions of a Rel protein with its inhibitor.

1995 • 48 citations

Review

1994 • 45 citations

Molecular genetics of Drosophila immunity

1994 • 44 citations

Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

1993 • 42 citations

Regulated Nuclear Import of the Drosophila Rel Protein Dorsal: Structure-Function Analysis

1996 • 35 citations

Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.

1994 • 34 citations

The structure of the NF‐κB p50:DNA‐complex a starting point for analyzing the Rel family

1995 • 34 citations

Specificity of Rel-Inhibitor Interactions in Drosophila Embryos

1995 • 32 citations

The decapentaplegic Core Promoter Region Plays an Integral Role in the Spatial Control of Transcription

1995 • 30 citations

Insect Immunity

1985 • 19 citations