Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Left Ventricular Hypertrophy

2000 • 1,197 citations

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

1997 • 1,138 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy

2001 • 696 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

2002 • 467 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type

2000 • 455 citations

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

2001 • 412 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy

2000 • 390 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun

1999 • 373 citations

Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway

2001 • 357 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload

2000 • 308 citations

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

2000 • 298 citations

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

2001 • 293 citations

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

1998 • 271 citations

Transient cardiac expression of constitutively active Gα_qleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

1998 • 262 citations

Regulation of the Growth of Multinucleated Muscle Cells by an Nfatc2-Dependent Pathway

2001 • 252 citations

Impaired cardiac hypertrophic response in Calcineurin Aβ -deficient mice

2002 • 240 citations

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

2000 • 232 citations

An abnormal Ca2+ response in mutant sarcomere protein–mediated familial hypertrophic cardiomyopathy

2000 • 232 citations

Calcineurin and Beyond

2000 • 227 citations

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

2000 • 216 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

1996 • 203 citations

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

2001 • 202 citations

Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors

2000 • 196 citations

The Nuclear Factor of Activated T Cells (Nfat) Transcription Factor Nfatp (Nfatc2) Is a Repressor of Chondrogenesis

2000 • 190 citations

Cyclosporine Attenuates Pressure-Overload Hypertrophy in Mice While Enhancing Susceptibility to Decompensation and Heart Failure

1999 • 180 citations

Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of Calcineurin

1999 • 158 citations

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

2000 • 157 citations

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

1997 • 154 citations

Calcineurin Enhances MEF2 DNA Binding Activity in Calcium-dependent Survival of Cerebellar Granule Neurons

1999 • 147 citations

Calcineurin Plays a Critical Role in Pressure Overload–Induced Cardiac Hypertrophy

1999 • 147 citations

Nonenzymatic separation of myocardial cell nuclei from whole heart tissue

1983 • 146 citations

Failure of Calcineurin Inhibitors to Prevent Pressure-Overload Left Ventricular Hypertrophy in Rats

1999 • 142 citations

The Calcium/Calmodulin-dependent Protein Phosphatase Calcineurin Is the Major Elk-1 Phosphatase

1997 • 132 citations

Calcineurin Plays a Critical Role in the Development of Pressure Overload–Induced Cardiac Hypertrophy

2001 • 129 citations

Electrical Stimulation of Neonatal Cardiac Myocytes Activates the NFAT3 and GATA4 Pathways and Up-regulates the Adenylosuccinate Synthetase 1 Gene

2000 • 125 citations

Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy

2002 • 120 citations

Altered Primary Myogenesis in NFATC3−/− Mice Leads to Decreased Muscle Size in the Adult

2001 • 119 citations

Structure of a TonEBP–DNA complex reveals DNA encircled by a transcription factor

2002 • 118 citations

Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)

1999 • 105 citations

Calcineurin Inhibition Attenuates Mineralocorticoid-Induced Cardiac Hypertrophy

2002 • 92 citations

Na+-Ca2+ Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy

2001 • 88 citations

Calcineurin Inhibitor Attenuates Left Ventricular Hypertrophy, Leading to Prevention of Heart Failure in Hypertensive Rats

2000 • 85 citations

Calcineurin Is Activated in Rat Hearts With Physiological Left Ventricular Hypertrophy Induced by Voluntary Exercise Training

2000 • 77 citations

Cyclosporin A Protects Against Angiotensin II–Induced End-Organ Damage in Double Transgenic Rats Harboring Human Renin and Angiotensinogen Genes

2000 • 73 citations

Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats

2000 • 69 citations

Calcineurin Blockade Prevents Cardiac Mitogen-activated Protein Kinase Activation and Hypertrophy in Renovascular Hypertension

2000 • 63 citations

Inhibition of Calcineurin and Sarcolemmal Ca ²⁺ Influx Protects Cardiac Morphology and Ventricular Function in K _v 4.2N Transgenic Mice

2002 • 61 citations

Calcineurin Inhibitor Attenuates the Development and Induces the Regression of Cardiac Hypertrophy in Rats With Salt-Sensitive Hypertension

2000 • 46 citations

Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium

2000 • 46 citations

Calcineurin Inhibition Ameliorates Structural, Contractile, and Electrophysiologic Consequences of Postinfarction Remodeling

2001 • 41 citations

Cyclosporine Reduces Left Ventricular Mass with Chronic Aortic Banding in Mice, Which Could be due to Apoptosis and Fibrosis

2001 • 39 citations

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

1997 • 34 citations

Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats.

2001 • 33 citations

[Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension].

2001 • 8 citations

Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder.

2001 • 7 citations