Cyclosporin A Protects Against Angiotensin II–Induced End-Organ Damage in Double Transgenic Rats Harboring Human Renin and Angiotensinogen Genes

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells

1999 • 483 citations

Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response

1990 • 483 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Erratum to: Cyclosporin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Use in Immunoregulatory Disorders

1993 • 444 citations

Cyclosporin

1993 • 439 citations

Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors

1999 • 374 citations

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

1990 • 364 citations

Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.

1992 • 230 citations

Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner

1991 • 226 citations

Monocyte Infiltration and Adhesion Molecules in a Rat Model of High Human Renin Hypertension

1999 • 220 citations

Hypertension-Induced End-Organ Damage

1999 • 207 citations

Signaling in Myocardial Hypertrophy

1999 • 199 citations

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo.

1996 • 197 citations

Cyclosporine Attenuates Pressure-Overload Hypertrophy in Mice While Enhancing Susceptibility to Decompensation and Heart Failure

1999 • 180 citations

Induction of Interleukin-6 Expression by Angiotensin II in Rat Vascular Smooth Muscle Cells

1999 • 178 citations

Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of Calcineurin

1999 • 158 citations

Adult human vascular endothelial cells express the IL6 gene differentially in response to LPS or IL1

1989 • 147 citations

Failure of Calcineurin Inhibitors to Prevent Pressure-Overload Left Ventricular Hypertrophy in Rats

1999 • 142 citations

High Human Renin Hypertension in Transgenic Rats

1997 • 135 citations

Prevention of Cardiac Hypertrophy by Calcineurin Inhibition

1999 • 126 citations

Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells.

1995 • 100 citations

Synergistic regulatory effects of interleukin 6 and interleukin 1 on the growth and differentiation of human and mouse myeloid leukemic cell lines.

1989 • 68 citations

Effects of Dietary Sodium and Magnesium on Cyclosporin A–Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats

1997 • 58 citations

The Role of Interleukin 6 in Megakaryocyte Formation, Megakaryocyte Development and Platelet Production

2007 • 48 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

CYCLOSPORINE INDUCES THE EXPRESSION OF THE CYCLIN INHIBITOR p21

1999 • 44 citations

Phorbol Ester and Interleukin-1 Induce Interleukin-6 Gene Expression in Vascular Smooth Muscle Cells Via Independent Pathways

1997 • 25 citations