Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

1990 • 5,586 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

The renaissance of GSK3

2001 • 1,459 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure

2000 • 890 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

Recombineering: a powerful new tool for mouse functional genomics

2001 • 743 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Crystal Structure of Glycogen Synthase Kinase 3β

2001 • 636 citations

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

2000 • 607 citations

Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

1994 • 578 citations

Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure

2000 • 542 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

1998 • 496 citations

Stress Pathways and Heart Failure

1999 • 463 citations

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

2001 • 430 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling

2000 • 414 citations

Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy

2000 • 390 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Decoding calcium signals involved in cardiac growth and function

2000 • 348 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload

2000 • 308 citations

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

2000 • 298 citations

Calcineurin Signaling and Muscle Remodeling

2000 • 290 citations

Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A

2001 • 277 citations

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy

2001 • 270 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes

2000 • 254 citations

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

1998 • 234 citations

Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo

2000 • 228 citations

Calcineurin and Beyond

2000 • 227 citations

Gβγ-dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy

2000 • 202 citations

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

1995 • 168 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

c-Jun NH₂-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

2000 • 130 citations

Solution Structure of the Core NFATC1/DNA Complex

1998 • 107 citations

Identification of a putative regulator of early T cell activation genes. Science. 1988. 241: 202-205.

2010 • 98 citations

Extracellular Signal-regulated Protein Kinase Activation Is Required for the Anti-hypertrophic Effect of Atrial Natriuretic Factor in Neonatal Rat Ventricular Myocytes

1999 • 98 citations

Angiotensin II and Serum Differentially Regulate Expression of Cyclins, Activity of Cyclin-Dependent Kinases, and Phosphorylation of Retinoblastoma Gene Product in Neonatal Cardiac Myocytes

1997 • 79 citations

From the Sarcomere to the Nucleus: Role of Genetics and Signaling in Structural Heart Disease

2000 • 79 citations

Meeting Koch’s postulates for calcium signaling in cardiac hypertrophy

2000 • 72 citations

Calcineurin inhibition and cardiac hypertrophy: A matter of balance

2001 • 59 citations

Missing Links in GSK3 Regulation

2001 • 59 citations