Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Calcium signaling

1995 • 1,905 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Ras effectors

1996 • 445 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Signal transduction and gene regulation: the nuclear response to cAMP

1994 • 369 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

The Ras signal transduction pathway

1994 • 345 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

The ETS-domain transcription factor family

1997 • 322 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

1996 • 293 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

Glucose, Other Secretagogues, and Nerve Growth Factor Stimulate Mitogen-activated Protein Kinase in the Insulin-secreting β-Cell Line, INS-1

1995 • 222 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca²⁺/Calmodulin-Dependent Kinase

1995 • 215 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

Neurotransmitter- and Growth Factor-Induced cAMP Response Element Binding Protein Phosphorylation in Glial Cell Progenitors: Role of Calcium Ions, Protein Kinase C, and Mitogen-Activated Protein Kinase/Ribosomal S6 Kinase Pathway

1997 • 189 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

1997 • 162 citations

Calcineurin: Not Just a Simple Protein Phosphatase

1997 • 159 citations

Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig.

1995 • 156 citations

Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin

1991 • 155 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes.

1994 • 141 citations

The Calcium/Calmodulin-dependent Protein Phosphatase Calcineurin Is the Major Elk-1 Phosphatase

1997 • 132 citations

Calcineurin Is a Key Signaling Enzyme in T Lymphocyte Activation and the Target of the Immunosuppressive Drugs Cyclosporin A and FK506^a

1993 • 131 citations

Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.

1993 • 125 citations

Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade

1996 • 122 citations

“Tell Me Where Is Calcium Bred”: Clarifying the Roles of Nuclear Calcium

1998 • 121 citations

pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast

1998 • 121 citations

Signal integration at the c-fos promoter

1995 • 109 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Protein serine/threonine phosphatases

1996 • 105 citations

Inhibitory Cross-talk by cAMP Kinase on the Calmodulin-dependent Protein Kinase Cascade

1997 • 90 citations

Cyclosporin A Inhibits Nitric Oxide Synthase Induction in Vascular Smooth Muscle Cells

1995 • 90 citations

Distinct tissue and cellular distribution of two major isoforms of calcineurin

1997 • 90 citations

Gene Regulation by Nuclear and Cytoplasmic Calcium Signals

1997 • 86 citations

Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line

1994 • 84 citations

Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1

1995 • 72 citations

Deuterium Exchange Mass Spectrometry as a Probe of Protein Kinase Activation. Analysis of Wild-Type and Constitutively Active Mutants of MAP Kinase Kinase-1

1998 • 70 citations

Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1)

1998 • 67 citations

Protein engineering and NMR studies of calmodulin

1995 • 58 citations

Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis

1996 • 53 citations

T cell antigen receptor signal transduction pathways.

1996 • 49 citations

Selective activation of JNK/SAPK by interleukin‐1 in rabbit liver is mediated by MKK7

1997 • 41 citations

Regulation of the c-fos Promoter

1995 • 34 citations

Calcineurin—immunosuppressor complexes

1996 • 23 citations