Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of Calcineurin

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Cardiac hypertrophy. Mechanical, neural, and endocrine dependence.

1991 • 625 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

1993 • 359 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac G _sα Overexpression

1996 • 266 citations

Pressure Overload Induces Cardiac Hypertrophy in Angiotensin II Type 1A Receptor Knockout Mice

1998 • 259 citations

Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.

1994 • 240 citations

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1997 • 234 citations

Protein Kinase C, but Not Tyrosine Kinases or Ras, Plays a Critical Role in Angiotensin II-induced Activation of Raf-1 Kinase and Extracellular Signal-regulated Protein Kinases in Cardiac Myocytes

1996 • 211 citations

cis -Acting Sequences That Mediate Induction of β-Myosin Heavy Chain Gene Expression During Left Ventricular Hypertrophy due to Aortic Constriction

1997 • 177 citations

Mechanical Stretch Induces Hypertrophic Responses in Cardiac Myocytes of Angiotensin II Type 1a Receptor Knockout Mice

1998 • 145 citations

Cardiac myocytes as targets for the action of peptide growth factors.

1990 • 126 citations

Treatment With Growth Hormone Enhances Contractile Reserve and Intracellular Calcium Transients in Myocytes From Rats With Postinfarction Heart Failure

1999 • 118 citations

Angiotensin AT ₁ Receptor Inhibition

1997 • 94 citations

Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.

1997 • 78 citations

Pathologic changes in the long-term transplanted heart: A morphometric study of myocardial hypertrophy, vascularity, and fibrosis

1990 • 70 citations

Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding.

1995 • 63 citations

Calcineurin Inhibition and Cardiac Hypertrophy

1998 • 56 citations

QUANTITATING IMMUNOSUPPRESSION

1996 • 52 citations

CYCLOSPORINE INHIBITION OF LEUKOCYTE CALCINEURIN IS MUCH LESS IN WHOLE BLOOD THAN IN CULTURE MEDIUM

1996 • 41 citations

Myocyte Hypertrophy in the Transplanted Heart A Morphometric Analysis

1987 • 36 citations

Signaling Hypertrophy

1998 • 36 citations

Calcineurin—the missing link in cardiac hypertrophy

1998 • 32 citations

The downstream consequences of calcineurin inhibition

1997 • 22 citations

Signaling Path May Lead to Better Heart-Failure Therapies

1998 • 11 citations