Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1983 • 225 citations

Granzyme A is an interleukin 1 beta-converting enzyme.

1995 • 217 citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1995 • 216 citations

Establishment of a germ-line competent C57BL/6 embryonic stem cell line

1991 • 204 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

1976 • 173 citations

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells

1991 • 166 citations

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.

1995 • 149 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes.

1994 • 125 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.

1986 • 112 citations

Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro

1991 • 93 citations

Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells

1990 • 93 citations

Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.

1994 • 93 citations

Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.

1994 • 91 citations

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

1989 • 81 citations

Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.

1992 • 58 citations

In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

1991 • 44 citations

Expression of cytoplasmic granules with T cell‐associated serine proteinase‐1 activity in Ly‐2(CD8) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo

1989 • 41 citations

A 14,000 MW lipoprotein and a glycolipid-like structure of Borrelia burgdorferi induce proliferation and immunoglobulin production in mouse B cells at high frequencies.

1994 • 38 citations

Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny.

1995 • 26 citations

Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.

1994 • 24 citations

The T cell‐specific serine proteinase TSP‐1 is associated with cytoplasmic granules of cytolytic T lymphocytes

1987 • 24 citations

Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes

1990 • 23 citations

Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis.

1995 • 22 citations

Target Cell Lysis by Natural Killer Cells is Influenced by β₂‐Microglobulin Expression

1989 • 22 citations

Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1− inbred mouse strains and their progeny

1992 • 16 citations

Organization of the gene encoding the mouse T-cell-specific serine proteinase “granzyme A”

1992 • 14 citations