Expression and Purification of Enzymatically Active Recombinant Granzyme B in a Baculovirus System

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

The Baculovirus Expression System: A Laboratory Guide

1993 • 404 citations

Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan.

1984 • 390 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1995 • 216 citations

The role of the Caspase family of cysteine proteases in apoptosis

1997 • 210 citations

The oligosaccharides of influenza virus hemagglutinin expressed in insect cells by a baculovirus vector

1990 • 204 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Activation of Caspase-2 in Apoptosis

1997 • 181 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.

1995 • 149 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.

1995 • 127 citations

Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.

1993 • 116 citations

The Tryptase, Mouse Mast Cell Protease 7, Exhibits Anticoagulant Activity in Vivo and in Vitro Due to Its Ability to Degrade Fibrinogen in the Presence of the Diverse Array of Protease Inhibitors in Plasma

1997 • 114 citations

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1997 • 108 citations

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide.

1993 • 81 citations

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

1988 • 80 citations

Mechanisms of Lysis by Cytotoxic T Cells

1995 • 79 citations

Immunopurification of Functional Asp-ase (Natural Killer Cell Granzyme B) Using a Monoclonal Antibody

1993 • 61 citations

Expression of gag precursor protein and secretion of virus-like gag particles of HIV-2 from recombinant baculovirus-infected insect cells

1990 • 57 citations

Expression and characterization of the Ha-ras p21 protein produced at high levels in the insect/baculovirus system

1989 • 49 citations

Binding of Granzyme B in the Nucleus of Target Cells

1996 • 34 citations

Activationin vitroof RNA polymerase II and III directed transcription by baculovirus produced E1A protein

1990 • 21 citations