Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

The Myeloid Leukemia-associated Protein SET Is a Potent Inhibitor of Protein Phosphatase 2A

1996 • 463 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

1992 • 392 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

1995 • 238 citations

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

1985 • 231 citations

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1983 • 225 citations

Granzyme A is an interleukin 1 beta-converting enzyme.

1995 • 217 citations

S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1

1991 • 191 citations

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1995 • 186 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Molecular Identification of I₁^PP2A, a Novel Potent Heat-Stable Inhibitor Protein of Protein Phosphatase 2A

1996 • 173 citations

Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.

1995 • 173 citations

Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.

1994 • 171 citations

Anionic regions in nuclear proteins.

1987 • 167 citations

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.

1995 • 156 citations

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.

1995 • 149 citations

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.

1996 • 139 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.

1996 • 117 citations

can, a Putative Oncogene Associated with Myeloid Leukemogenesis, May Be Activated by Fusion of Its 3‣ Half to Different Genes: Characterization of the set Gene

1992 • 104 citations

Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases

1994 • 101 citations

The Isolation and Characterization of a Family of Serine Protease Genes Expressed in Activated Cytotoxic T Lymphocytes

1988 • 95 citations

Purification and Characterization of Two Putative HLA Class II Associated Proteins: PHAPI and PHAPII

1994 • 93 citations

Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro

1991 • 93 citations

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins

1993 • 86 citations

A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons.

1994 • 76 citations

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.

1987 • 70 citations

Expression of Human Recombinant Granzyme A Zymogen and Its Activation by the Cysteine Proteinase Cathepsin C

1996 • 70 citations

Molecular cloning of the cDNA for the human U2 snRNA-specific A′ protein

1989 • 53 citations

Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia

1994 • 49 citations

Hydrolysis of myelin basic protein in myelin membranes by granzymes of large granular lymphocytes.

1993 • 26 citations

Studies of Specificity and Catalysis in Trypsin by Structural Analysis of Site-Directed Mutants

1988 • 21 citations

The occurrence of extended acidic sequences in nonhistone chromosomal proteins

1986 • 19 citations

Localization of the Gene Encoding the Putative Human HLA Class II Associated Protein (PHAPI) to Chromosome 15q22.3-q23 by Fluorescence in Situ Hybridization

1995 • 11 citations

Molecular Analysis and Possible Pleiotropic Function(s) of the T Cell-Specific Serine Proteinase-1 (TSP-1)

1993 • 9 citations