Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Caspases: killer proteases

1997 • 2,440 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.

1989 • 511 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

1997 • 439 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

1997 • 339 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.

1996 • 270 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

1997 • 237 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

Regulation of the Fas Apoptotic Cell Death Pathway by Abl

1995 • 146 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Nuclear Transport of Granzyme B (Fragmentin-2)

1996 • 104 citations

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1996 • 102 citations

Localization of Granzyme B in the Nucleus

1996 • 102 citations

Immunolocalization of the ICE/Ced-3–Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes

1997 • 98 citations

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

1996 • 54 citations

Binding of Granzyme B in the Nucleus of Target Cells

1996 • 34 citations

[5] Granzyme B

1994 • 29 citations