Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replication

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Alternative activation of macrophages

2003 • 5,952 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

2002 • 1,339 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

Dectin-1 Mediates the Biological Effects of β-Glucans

2003 • 1,167 citations

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

2000 • 789 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

The Toll receptor family and microbial recognition

2000 • 671 citations

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

1998 • 640 citations

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

2001 • 593 citations

The smallest known non-avian theropod dinosaur

2000 • 530 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

Evasion of innate immunity by parasitic protozoa

2002 • 429 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite

1998 • 371 citations

Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2

2003 • 345 citations

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

1985 • 338 citations

Immunological Phenomena in Leprosy and Related Diseases

1971 • 322 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling

2003 • 296 citations

An Immunomodulatory Function for Neutrophils During the Induction of a CD4+ Th2 Response in BALB/c Mice Infected withLeishmania major

2000 • 289 citations

Neutrophil granulocytes – Trojan horses for Leishmania major and other intracellular microbes?

2003 • 274 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Inhibition of the Spontaneous Apoptosis of Neutrophil Granulocytes by the Intracellular Parasite Leishmania major

2002 • 264 citations

The Inhibition of Arginase by Nω-Hydroxy-<scp>l</scp>-Arginine Controls the Growth of Leishmania Inside Macrophages

2001 • 262 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan ParasiteLeishmania major

2004 • 238 citations

Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation

1987 • 233 citations

Mini‐review Toll‐like receptors: networking for success

2003 • 228 citations

Fibroblasts as Host Cells in Latent Leishmaniosis

2000 • 211 citations

The role of phosphoglycans inLeishmania–sand fly interactions

2000 • 198 citations

Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response

2003 • 191 citations

A simple method for quantifying Leishmania in tissues of infected animals

1997 • 172 citations

Persistence Without Pathology in Phosphoglycan-Deficient Leishmania major

2003 • 170 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Intracellular Survival ofLeishmania majorin Neutrophil Granulocytes after Uptake in the Absence of Heat-Labile Serum Factors

2002 • 160 citations

Killing of Leishmania Parasites in Activated Murine Macrophages is Based on an L-Arginine-Dependent Process That Produces Nitrogen Derivatives

1991 • 158 citations

Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites

2002 • 155 citations

The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid.

1987 • 141 citations

Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice

1992 • 124 citations

Toll‐like receptor 4 expression levels determine the degree of LPS‐susceptibility in mice

2003 • 102 citations

Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice

1992 • 91 citations

The lipophosphoglycan of Leishmania

1988 • 87 citations

Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice

2000 • 85 citations

Interleukin-12 is indispensable for protective immunity against Leishmania major

1997 • 85 citations

Leishmania major activates IL-1α expression in macrophages through a MyD88-dependent pathway

2002 • 77 citations

Trypanosoma spp., Leishmania spp. and Leptomonas spp.: Enzymes of ornithine-arginine metabolism

1978 • 71 citations

A Point Mutation in the IL-12Rβ2 Gene Underlies the IL-12 Unresponsiveness of Lps-Defective C57BL/10ScCr Mice

2001 • 71 citations

Gamma interferon production in endotoxin-responder and -nonresponder mice during infection

1991 • 69 citations

Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4.

1997 • 54 citations

Inherited IL-12 Unresponsiveness Contributes to the High LPS Resistance of theLpsd C57BL/10ScCr Mouse

2001 • 48 citations

Progressive disease or protective immunity to Leishmania major infection: the result of a network of stimulatory and inhibitory interactions

1998 • 47 citations

Interferon β, a cofactor in the interferon γ production induced by gram-negative bacteria in mice.

1995 • 46 citations

Leishmania major infection in C57BL/10 mice differing at the Lps locus: a new non-healing phenotype

1997 • 35 citations

IL-12Rβ2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response

2003 • 25 citations

The leishmaniasis model

2002 • 21 citations

4.2 The Leishmaniasis Model

1998 • 15 citations

Immunoregulation in leishmaniasis

1994 • 13 citations

INTERFERON-??, A COFACTOR IN THE INTERFERON-?? PRODUCTION INDUCED BY GRAM-NEGATIVE BACTERIA IN MICE

1995 • 9 citations