Interleukin-12 is indispensable for protective immunity against Leishmania major

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Dendritic cells in Leishmania major‐immune mice harbor persistent parasites and mediate an antigen‐specific T cell immune response

1995 • 172 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Immunology of leishmaniasis

1992 • 162 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE

1984 • 128 citations

The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis

1989 • 113 citations

Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and self-healing infection in the mouse.

1976 • 101 citations

Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses.

1991 • 89 citations

Leishmania major:Effect of Infectious Dose on T Cell Subset Development in BALB/c Mice

1996 • 67 citations

Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge

1996 • 65 citations

Immunity to experimental infection with Leishmania major: generation of protective L3T4⁺ T cell clones recognizing antigen(s) associated with live parasites

1989 • 56 citations

Antigen Dose-Dependent Regulation of Bε-Memory Cell Expression

1991 • 31 citations

Distinct immunological states in murine cutaneous leishmaniasis by immunising with different amounts of antigen: the generation of beneficial, potentially harmful, harmful and potentially extremely harmful states.

1997 • 30 citations