Leishmania major activates IL-1α expression in macrophages through a MyD88-dependent pathway

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

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1999 • 1,190 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

2001 • 593 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression.

1994 • 334 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation

1987 • 233 citations

Transforming Growth Factor-β1 Induces Interleukin-6 Expression via Activating Protein-1 Consisting of JunD Homodimers in Primary Human Lung Fibroblasts

1999 • 182 citations

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction inLeishmania -infected cells

1998 • 145 citations

Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1.

1990 • 102 citations

Phagocytosis ofLeishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1998 • 94 citations

Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans

1999 • 92 citations

Leishmania-macrophage interactions: multiple receptors, multiple ligands and diverse cellular responses

1993 • 82 citations

Leishmania major:Infection of Human Monocytes Induces Expression of IL-8 and MCAF

1996 • 74 citations

Enhancement of macrophage IL-1 production by Leishmania major infection in vitro and its inhibition by IFN-gamma.

1989 • 67 citations

Leishmania major-parasitized macrophages augment Th2-type T cell activation.

1994 • 55 citations

Lipophosphoglycan fromLeishmaniasuppresses agonist-induced interleukin 1β gene expression in human monocytes via a unique promoter sequence

1996 • 47 citations

Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses

1999 • 37 citations

Parasite-Monocyte Interactions in Human Leishmaniasis: Production of Interleukin-1 in Vitro

1985 • 31 citations

Serotonin-inducible transcription of interleukin-1α in uterine smooth muscle cells requires an AP-1 site: cloning and partial characterization of the rat IL-1α promoter

1999 • 17 citations

Interleukin 1α Activity of Peritoneal and Bone Marrow Macrophages Infected with Leishmania major and Leishmania donovani in Vitro

2000 • 9 citations