An Immunomodulatory Function for Neutrophils During the Induction of a CD4+ Th2 Response in BALB/c Mice Infected withLeishmania major

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Data analysis

1996 • 2,754 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1995 • 535 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response

1992 • 459 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

1997 • 432 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

1985 • 369 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 367 citations

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

1994 • 352 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Interleukin‐12 production by human polymorphonuclear leukocytes

1995 • 285 citations

Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice

1993 • 277 citations

Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3.

1993 • 252 citations

Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection.

1994 • 242 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

1997 • 194 citations

Neutrophil Granulocyte–committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics

1998 • 192 citations

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.

1997 • 183 citations

Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens.

1999 • 174 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Production of Interferon-Gamma during Infection of Mice with Plasmodium chabaudi chabaudi

1989 • 157 citations

Activation of Human T Cells by Major Histocompatability Complex Class II Expressing Neutrophils: Proliferation in the Presence of Superantigen, But Not Tetanus Toxoid

1997 • 152 citations

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

1998 • 151 citations

Human Polymorphonuclear Leukocytes Produce IL-12, TNF-α, and the Chemokines Macrophage-Inflammatory Protein-1α and -1β in Response toToxoplasma gondiiAntigens

1999 • 141 citations

Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness.

1997 • 129 citations

Responsiveness of human neutrophils to interleukin-4: induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis

1997 • 128 citations

Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice

1992 • 124 citations

TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes.

1998 • 124 citations

Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.

1998 • 117 citations

The IL-4 Rapidly Produced in BALB/c Mice After Infection with Leishmania major Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

1998 • 112 citations

TGF-β Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes

1998 • 107 citations

Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies

1984 • 101 citations

Regulation of protective immunity against Leishmania major in mice

1998 • 100 citations

Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells

1998 • 96 citations

Recognition of protozoan parasite antigens by murine T lymphocytes I. Induction of specific T lymphocyte‐dependent proliferative response to Leishmania tropica

1979 • 88 citations

Role of polymorphonuclear neutrophil leukocytes and their integrin CD11a (LFA-1) in the pathogenesis of severe murine malaria

1994 • 85 citations

The role of polymorphonuclear leukocytes in the resistance to cutaneous Leishmaniasis

1998 • 78 citations

Role of transforming growth factor‐βthe preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B

1993 • 71 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 43 citations

Toxoplasma gondiiTriggers Granulocyte-Dependent Cytokine-Mediated Lethal Shock in<scp>d</scp>-Galactosamine-Sensitized Mice

1998 • 38 citations

Respective role of polymorphonuclear leukocytes and their integrins (CD-11/18) in the local or systemic toxicity of lipopolysaccharide

1993 • 23 citations