The leishmaniasis model

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Nitric oxide and the immune response

2001 • 3,222 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

1998 • 640 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

1995 • 553 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Identification of an Infective Stage of Leishmania Promastigotes

1984 • 498 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

Salivary Gland Lysates from the Sand Fly Lutzomyia longipalpis Enhance Leishmania Infectivity

1988 • 454 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin

1986 • 340 citations

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

1985 • 338 citations

Immunology of Leishmaniasis

1993 • 337 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation

1987 • 233 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to leishmania tropica

1981 • 199 citations

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

1995 • 179 citations

A simple method for quantifying Leishmania in tissues of infected animals

1997 • 172 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Immunology of leishmaniasis

1992 • 162 citations

Cell Separation: Methods and Selected Applications

1983 • 158 citations

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1999 • 156 citations

Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites

2002 • 155 citations

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication.

1996 • 151 citations

Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

1997 • 144 citations

The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid.

1987 • 141 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model

1984 • 121 citations

Developmental modification of the lipophosphoglycan from Leishmania major promastigotes during metacyclogenesis

1990 • 120 citations

Leishmania mexicana: Induction of Metacyclogenesis by Cultivation of Promastigotes at Acidic pH

1993 • 116 citations

Establishment of resistance to Leishmania major infection in susceptible BALB/c mice requires parasite-specific CD8⁺ T cells

1991 • 112 citations

Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and self-healing infection in the mouse.

1976 • 101 citations

A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasites

1990 • 94 citations

Cell propagation on films of polymeric fluorocarbon as a means to regulate pericellular pH and pO₂ in cultured monolayers

1971 • 85 citations

Single gene control of resistance to cutaneous leishmaniasis in mice

1981 • 83 citations

Advantages of measuring changes in the number of viable parasites in murine models of experimental cutaneous leishmaniasis

1983 • 79 citations

A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice.

1989 • 74 citations

NO as an affector molecule of parasite killing: modulation of its synthesis by cytokines

1994 • 73 citations

Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge

1996 • 65 citations

Limiting Dilution Assays for the Separation, Characterization, and Quantitation of Biologically Active Particles and Their Clonal Progeny

1987 • 54 citations

Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4.

1997 • 54 citations

Experimental Cutaneous Leishmaniasis: Disseminated Leishmaniasis in Genetically Susceptible and Resistant Mice

1982 • 53 citations

Site-specific immunity to Leishmania major in SWR mice: the site of infection influences susceptibility and expression of the antileishmanial immune response

1994 • 50 citations

Progressive disease or protective immunity to Leishmania major infection: the result of a network of stimulatory and inhibitory interactions

1998 • 47 citations

Systemic infection of Leishmania tropica (major) in various strains of mice

1981 • 47 citations

Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 duringLeishmania major infection

1999 • 42 citations

Nitrogen and oxygen metabolites and the killing of Leishmania by activated murine macrophages

1991 • 36 citations

Molecular and immune mechanisms in the pathogenesis of cutaneous leishmaniasis

1996 • 36 citations

Immunoregulation in leishmaniasis

1994 • 13 citations

Leishmaniasis in the Americas.

1994 • 10 citations

Experimentally induced cutaneous Leishmaniasis: are L3T4+ T cells that promote parasite growth distinct from those mediating resistance?

1988 • 10 citations

Vaccine: the only hope to control leishmaniasis.

1996 • 8 citations