A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

The versatility and universality of calcium signalling

2000 • 5,407 citations

Drug repositioning: identifying and developing new uses for existing drugs

2004 • 2,868 citations

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Small-cell lung cancer

2011 • 1,170 citations

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

2011 • 793 citations

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

2012 • 760 citations

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

2012 • 658 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

2011 • 576 citations

Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

2012 • 479 citations

Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today

2009 • 420 citations

Molecular genetics of small cell lung carcinoma

2001 • 378 citations

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

2011 • 287 citations

Systematic Drug Repositioning Based on Clinical Side-Effects

2011 • 259 citations

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

2010 • 250 citations

A crucial requirement for Hedgehog signaling in small cell lung cancer

2011 • 238 citations

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung Carcinoma

2010 • 236 citations

Management of Small Cell Lung Cancer

2007 • 220 citations

Autocrine and paracrine signaling through neuropeptide receptors in human cancer

2001 • 196 citations

SnapShot: Non-Small Cell Lung Cancer

2012 • 186 citations

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

2008 • 174 citations

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

2013 • 143 citations

M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion

2007 • 139 citations

Tricyclic Antidepressant Concentrations in Plasma

1994 • 134 citations

Molecular Target Class Is Predictive of In vitro Response Profile

2010 • 125 citations

A Computational Approach to Finding Novel Targets for Existing Drugs

2011 • 121 citations

Neuropeptides as Autocrine Growth Factors in Cancer Cells

2003 • 120 citations

Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis

2011 • 118 citations

Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD

2010 • 111 citations

Regulation of Signal Transduction Pathways and Gene Expression by Mood Stabilizers and Antidepressants

1999 • 108 citations

Antipsychotics in bipolar disorder.

1996 • 108 citations

Signalling specificity in GPCR-dependent Ca2+ signalling

2003 • 95 citations

G protein signaling and the molecular basis of antidepressant action

2003 • 93 citations

The G protein-coupled receptors: Pharmacogenetics and Disease

2005 • 90 citations

Neuronal characteristics of small-cell lung cancer

2005 • 86 citations

Recent progress in alpha1-adrenergic receptor research

2005 • 82 citations

Antiallergic Anti-Inflammatory Effects of H1-Antihistamines in Humans

2002 • 69 citations

Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers

2008 • 67 citations

Current Management of Small Cell Lung Cancer

2011 • 38 citations

Adjuvant and neoadjuvant therapy in prostate cancer

2001 • 36 citations

m3 Muscarinic Acetylcholine Receptor Regulation in the Airway

2002 • 33 citations

G-protein-coupled receptor agonists augment adenylyl cyclase activity induced by forskolin in human corpus cavernosum smooth muscle cells.

1997 • 33 citations

Distinct roles of cholinergic receptors in small cell lung cancer cells.

2010 • 21 citations

Anticholinergic activity of imipramine and some analogs at muscarinic receptors of cultured mouse neuroblastoma cells

1982 • 18 citations

Imipramine distribution among red blood cells, plasma and brain tissue.

1996 • 16 citations

Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis

2006 • 13 citations

Key amino acids for differential coupling of α1-adrenergic receptor subtypes to Gs

2002 • 8 citations