Back to search

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

Data up to Jan 2025

Published2011
Citations287
References63

Total Citations Per Year

Abstract

References (63)

Scalable molecular dynamics with NAMD

2005 • 16,463 citations

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

1998 • 13,827 citations

CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields

2009 • 6,094 citations

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

2005 • 5,799 citations

Extending the treatment of backbone energetics in protein force fields: Limitations of gas‐phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

2004 • 3,297 citations

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

2007 • 3,186 citations

Crystal structure of the β2 adrenergic receptor–Gs protein complex

2011 • 2,847 citations

Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method

2008 • 2,740 citations

The structure and function of G-protein-coupled receptors

2009 • 2,268 citations

PLUMED: A portable plugin for free-energy calculations with molecular dynamics

2009 • 1,626 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Heterotrimeric G protein activation by G-protein-coupled receptors

2007 • 1,100 citations

Crystal structure of opsin in its G-protein-interacting conformation

2008 • 1,042 citations

The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure

2004 • 1,025 citations

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

2007 • 1,021 citations

Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

2007 • 783 citations

Identification of a serotonin/glutamate receptor complex implicated in psychosis

2008 • 757 citations

Neurobiology of Schizophrenia

2006 • 670 citations

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

2007 • 661 citations

From A to B in free energy space

2007 • 523 citations

Protein–Protein Docking with Backbone Flexibility

2007 • 431 citations

Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies

2002 • 388 citations

Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

1996 • 342 citations

Forced unfolding of fibronectin type 3 modules: an analysis by biased molecular dynamics simulations

1999 • 338 citations

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

2009 • 324 citations

PCP: from pharmacology to modelling schizophrenia

2004 • 309 citations

G protein‐coupled receptor hetero‐dimerization: contribution to pharmacology and function

2009 • 309 citations

Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains

2000 • 287 citations

Detection of heteromerization of more than two proteins by sequential BRET-FRET

2008 • 267 citations

Effective energy function for proteins in lipid membranes

2003 • 267 citations

Phencyclidine animal models of schizophrenia: Approaches from abnormality of glutamatergic neurotransmission and neurodevelopment

2007 • 263 citations

Efficacy at g-protein-coupled receptors

2002 • 257 citations

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

2008 • 249 citations

A Multicenter, Inpatient, Phase 2, Double-Blind, Placebo-Controlled Dose-Ranging Study of LY2140023 Monohydrate in Patients With DSM-IV Schizophrenia

2011 • 246 citations

In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems

2008 • 237 citations

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

2011 • 219 citations

Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit

2007 • 211 citations

Molecular Interaction of Serotonin 5-HT2AReceptor Residues Phe339(6.51)and Phe340(6.52)with SuperpotentN-Benzyl Phenethylamine Agonists

2006 • 202 citations

5-hydroxytryptamine2A receptor inverse agonists as antipsychotics.

2001 • 190 citations

The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity

2007 • 188 citations

Characteristic Interactions with Phosphatidylinositol 4,5-Bisphosphate Determine Regulation of Kir Channels by Diverse Modulators

2004 • 179 citations

Psychedelics and schizophrenia

2009 • 163 citations

The α1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function

2007 • 159 citations

Probing the G-protein Regulation of GIRK1 and GIRK4, the Two Subunits of the KACh Channel, Using Functional Homomeric Mutants

1997 • 154 citations

The 'atypicality' of antipsychotics: a concept re-examined and re-defined

2009 • 145 citations

Identification of Conserved Aromatic Residues Essential for Agonist Binding and Second Messenger Production at 5-Hydroxytryptamine2AReceptors

1997 • 130 citations

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

2011 • 115 citations

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration

2009 • 115 citations

Identification of a Potassium Channel Site That Interacts with G Protein βγ Subunits to Mediate Agonist-induced Signaling

1999 • 111 citations

Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors

2008 • 109 citations

Identification of Critical Residues Controlling G Protein-gated Inwardly Rectifying K+ Channel Activity through Interactions with the βγ Subunits of G Proteins

2002 • 95 citations

Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.

1998 • 93 citations

An Epilepsy Mutation in the Sodium ChannelSCN1AThat Decreases Channel Excitability

2006 • 92 citations

Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques

2011 • 86 citations

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

2010 • 82 citations

Group II metabotropic glutamate receptors and schizophrenia

2009 • 62 citations

Disrupting 5-HT2A Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances SSRI Efficacy in Neuropathic Pain

2010 • 61 citations

Habituation Deficits Induced by Metabotropic Glutamate Receptors 2/3 Receptor Blockade in Mice: Reversal by Antipsychotic Drugs

2006 • 47 citations

Molecular modeling and docking studies of human 5-hydroxytryptamine 2A (5-HT2A) receptor for the identification of hotspots for ligand binding

2009 • 32 citations

Combined administration of an mGlu2/3 receptor agonist and a 5-HT2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants

2009 • 30 citations

The use of MK-801, a novel sympathomimetic, in adults with attention deficit disorder, residual type.

1986 • 22 citations

Quantitative stoichiometry of G-proteins activated by μ-opioid receptors in postmortem human brain

2002 • 15 citations

Cited By (0)

No citing papers found in database

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of… (2011) – Cell | Metascience Observatory Explorer