Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

Fiji: an open-source platform for biological-image analysis

2012 • 55,619 citations

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

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Malignant Gliomas in Adults

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Metastasis: from dissemination to organ-specific colonization

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Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer

1999 • 1,991 citations

High interstitial fluid pressure — an obstacle in cancer therapy

2004 • 1,979 citations

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

2011 • 1,639 citations

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

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A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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Interactions between cancer stem cells and their niche govern metastatic colonization

2011 • 1,246 citations

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

2007 • 1,089 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Balancing forces: architectural control of mechanotransduction

2011 • 911 citations

Breast Cancer Subtypes Based on ER/PR and Her2 Expression: Comparison of Clinicopathologic Features and Survival

2009 • 770 citations

Breast Cancer Subtypes Based on ER/PR and Her2 Expression: Comparison of Clinicopathologic Features and Survival

2009 • 707 citations

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

2004 • 618 citations

Glutamate release promotes growth of malignant gliomas

2001 • 556 citations

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

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Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

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Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling

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Subtype and pathway specific responses to anticancer compounds in breast cancer

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A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

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Tumor-Induced Sentinel Lymph Node Lymphangiogenesis and Increased Lymph Flow Precede Melanoma Metastasis

2007 • 370 citations

Mouse models of breast cancer metastasis

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Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

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Glutamate antagonists limit tumor growth

2001 • 270 citations

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

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Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

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Expression of glutamate receptor subunits in human cancers

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NMDA Receptor Activation Potentiates Inhibitory Transmission through GABA Receptor-Associated Protein-Dependent Exocytosis of GABA_AReceptors

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Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin.

2002 • 165 citations

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells

1999 • 130 citations

Tumor progression induced by the loss of E-cadherin independent of β-catenin/Tcf-mediated Wnt signaling

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Molecular Pathways: Dysregulated Glutamatergic Signaling Pathways in Cancer

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Regulation of tumor invasion by interstitial fluid flow

2011 • 117 citations

Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)

2006 • 105 citations

Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras‐MAPK signaling

2011 • 97 citations

Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry.

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Breast cancer expresses functional NMDA receptors

2009 • 91 citations

Morphological and Functional Characterization of βTC-6 Cells—an Insulin-Secreting Cell Line Derived From Transgenic Mice

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Cancer cell lines release glutamate into the extracellular environment

2009 • 82 citations

Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion

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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

2011 • 71 citations

Bimodal effects of MK-801 on locomotion and stereotypy in C57BL/6 mice

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Cancer cells release glutamate via the cystine/glutamate antiporter

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Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour

2011 • 58 citations

Characterization of vesicular glutamate transporter in pancreatic α- and β-cells and its regulation by glucose

2003 • 57 citations

Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

2010 • 56 citations

NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment

2010 • 54 citations

Metabotropic glutamate receptors: new targets for the control of tumor growth?

2007 • 46 citations

In the Absence of Sonic Hedgehog, p53 Induces Apoptosis and Inhibits Retinal Cell Proliferation, Cell-Cycle Exit and Differentiation in Zebrafish

2010 • 35 citations

Deploying Mouse Models of Pancreatic Cancer for Chemoprevention Studies

2010 • 28 citations

Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis

2010 • 20 citations