Recent progress in alpha1-adrenergic receptor research

Mammalian Sweet Taste Receptors

2001 • 1,550 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

G Protein-Coupled Receptor Allosterism and Complexing

2002 • 910 citations

G _h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function

1994 • 550 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

α ₁ -Adrenergic Receptor Subtypes

1996 • 509 citations

Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding.

1986 • 456 citations

α1-Adrenoceptor subtypes

1999 • 388 citations

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

1994 • 369 citations

Alpha1-adrenergic receptors: new insights and directions.

2001 • 328 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors

1995 • 296 citations

α1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates

2002 • 287 citations

Targeted Inactivation of Gh/Tissue Transglutaminase II

2001 • 285 citations

Decreased blood pressure response in mice deficient of the α _1b -adrenergic receptor

1997 • 282 citations

Heterogeneity of alpha 1-adrenergic receptors revealed by chlorethylclonidine.

1987 • 267 citations

GPCR interacting proteins (GIP)

2004 • 257 citations

Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

2002 • 227 citations

Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter

2001 • 215 citations

5-Methyl-urapidil discriminates between subtypes of the α1-adrenoceptor

1988 • 208 citations

The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction

2002 • 190 citations

The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

2003 • 186 citations

Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

2002 • 186 citations

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors

1989 • 173 citations

The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction

2002 • 168 citations

The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

2003 • 159 citations

Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors

2004 • 156 citations

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

2005 • 153 citations

Oligomerization of the α1a- and α1b-Adrenergic Receptor Subtypes

2003 • 152 citations

Targeted α _1A -Adrenergic Receptor Overexpression Induces Enhanced Cardiac Contractility but not Hypertrophy

2001 • 140 citations

Differences in the Cellular Localization and Agonist-Mediated Internalization Properties of the α₁-Adrenoceptor Subtypes

2002 • 133 citations

Heterodimerization with β₂-Adrenergic Receptors Promotes Surface Expression and Functional Activity of α_1D-Adrenergic Receptors

2004 • 132 citations

Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy

2000 • 125 citations

Dimers of Class A G Protein-coupled Receptors Function via Agonist-mediated Trans-activation of Associated G Proteins

2003 • 111 citations

α1-Adrenergic Receptor Signaling via Gh Is Subtype Specific and Independent of Its Transglutaminase Activity

1996 • 104 citations

Selective Inhibition of α1A-Adrenergic Receptor Signaling by RGS2 Association with the Receptor Third Intracellular Loop

2005 • 100 citations

Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor

2001 • 97 citations

Cloning, functional expression and tissue distribution of human α_1C‐adrenoceptor splice variants

1995 • 97 citations

Regulation of the Cellular Localization and Signaling Properties of the α_1B- and α_1D-Adrenoceptors by Agonists and Inverse Agonists

2000 • 95 citations

Subtype-Specific Dimerization of α₁-Adrenoceptors: Effects on Receptor Expression and Pharmacological Properties

2003 • 94 citations

Recent advances in α1-adrenoceptor pharmacology

2003 • 84 citations

Molecular cloning, genomic characterization and expression of novel human α_1A‐adrenoceptor isoforms

1998 • 83 citations

Update on human ?-adrenoceptor subtype signaling and genomic organization

2004 • 80 citations

A knockout approach indicates a minor vasoconstrictor role for vascular α _1B-adrenoceptors in mouse

2002 • 79 citations

The Adaptor Complex 2 Directly Interacts with the α1b-Adrenergic Receptor and Plays a Role in Receptor Endocytosis

2003 • 74 citations

The N Terminus of the Human α_1D-Adrenergic Receptor Prevents Cell Surface Expression

2004 • 71 citations

?1 Adrenoceptor subtypes: A synopsis of their pharmacology and molecular biology

1996 • 70 citations

High-Affinity Interactions between Human α_1A-Adrenoceptor C-Terminal Splice Variants Produce Homo- and Heterodimers but Do Not Generate the α_1L-Adrenoceptor

2004 • 67 citations

β-Adrenergic receptors and their interacting proteins

2004 • 64 citations

Interaction of the α1B-Adrenergic Receptor with gC1q-R, a Multifunctional Protein

1999 • 62 citations

Role of the α _1D - Adrenegric Receptor in the Development of Salt-Induced Hypertension

2002 • 60 citations

A Behavioral Study of Alpha-1b Adrenergic Receptor Knockout Mice: Increased Reaction to Novelty and Selectively Reduced Learning Capacities

2001 • 59 citations

Transgenic studies of α1-adrenergic receptor subtype function

2002 • 58 citations

Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA

2003 • 56 citations

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

2003 • 54 citations

Biochemistry and Pharmacology of Epitope-Tagged α₁-Adrenergic Receptor Subtypes

2002 • 52 citations

Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype

2004 • 51 citations

Adrenergic Pharmacology: Focus on the Central Nervous System

2001 • 48 citations

Design and Synthesis of Novel α_1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia

1998 • 47 citations

N-terminal truncation of human α1D-adrenoceptors increases expression of binding sites but not protein

2003 • 45 citations

α1-Adrenergic receptor subtypes: non-identical triplets with different dancing partners?

2003 • 43 citations

Pharmacological evidence for the role of central alpha 1B-adrenoceptors in the motor activity and spontaneous movement of mice

2001 • 41 citations

Abnormal Myocardial Contraction in α1A– and α1B–adrenoceptor double-knockout mice

2003 • 41 citations

Characteristics of behavioral abnormalities in α1d-adrenoceptors deficient mice

2004 • 40 citations

Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the α1b-adrenoceptor

2000 • 37 citations

Gene deletion of dopamine β-hydroxylase and α₁-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling

2004 • 33 citations

The α1B-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model

2003 • 33 citations

Subtype-selective Noncompetitive or Competitive Inhibition of Human α1-Adrenergic Receptors by ρ-TIA

2004 • 32 citations

Gene expression profile of neurodegeneration induced by 1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis

2003 • 30 citations

Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells.

2002 • 28 citations

Responses to noxious stimuli in mice lacking α1d-adrenergic receptors

2003 • 22 citations

Hepatocytes from α_1B‐adrenoceptor knockout mice reveal compensatory adrenoceptor subtype substitution

2004 • 21 citations

Addition of a signal peptide sequence to the α_1D‐adrenoceptor gene increases the density of receptors, as determined by [³H]‐prazosin binding in the membranes

2005 • 21 citations

Specific Interactions Between gC1qR and α₁‐Adrenoceptor Subtypes

2003 • 20 citations

Differential antagonism by conotoxin ρ-TIA of contractions mediated by distinct α1-adrenoceptor subtypes in rat vas deferens, spleen and aorta

2005 • 19 citations

Identification of ?1-adrenoceptor subtypes in the dog prostate

1993 • 15 citations

Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.

2004 • 15 citations

Novel antagonists for α1-adrenoceptor subtypes

2004 • 11 citations

[Binding between alpha 1A-adrenergic receptor and segment of bone morphogenetic protein-1 in human embryonic cell 293].

2003 • 5 citations