Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

Item-based collaborative filtering recommendation algorithms

2001 • 8,505 citations

Evaluating collaborative filtering recommender systems

2004 • 5,622 citations

Network medicine: a network-based approach to human disease

2010 • 4,396 citations

Network pharmacology: the next paradigm in drug discovery

2008 • 3,549 citations

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

2004 • 3,142 citations

From genomics to chemical genomics: new developments in KEGG

2005 • 3,004 citations

Drug repositioning: identifying and developing new uses for existing drugs

2004 • 2,868 citations

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

2002 • 2,782 citations

Relating protein pharmacology by ligand chemistry

2007 • 1,915 citations

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

2010 • 1,795 citations

Chemical Similarity Searching

1998 • 1,712 citations

Drug—target network

2007 • 1,625 citations

Predicting new molecular targets for known drugs

2009 • 1,599 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

Drug Target Identification Using Side-Effect Similarity

2008 • 1,200 citations

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

2004 • 1,111 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Prediction of drug–target interaction networks from the integration of chemical and genomic spaces

2008 • 1,019 citations

Solving the apparent diversity-accuracy dilemma of recommender systems

2010 • 922 citations

BRENDA, the enzyme database: updates and major new developments

2003 • 880 citations

Identification of a new class of steroid hormone receptors

1988 • 845 citations

Discovery of drug mode of action and drug repositioning from transcriptional responses

2010 • 803 citations

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

2011 • 793 citations

PREDICT: a method for inferring novel drug indications with application to personalized medicine

2011 • 760 citations

Network‐based global inference of human disease genes

2008 • 657 citations

SuperTarget and Matador: resources for exploring drug-target relationships

2007 • 600 citations

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

2011 • 576 citations

Development of a Chemical Structure Comparison Method for Integrated Analysis of Chemical and Genomic Information in the Metabolic Pathways

2003 • 465 citations

Predicting selective drug targets in cancer through metabolic networks

2011 • 464 citations

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework

2010 • 452 citations

TarFisDock: a web server for identifying drug targets with docking approach

2006 • 390 citations

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

2007 • 376 citations

Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features

2010 • 274 citations

Molecular Biology of Serotonin Receptors - Structure and Function at the Molecular Level

2002 • 269 citations

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

2009 • 258 citations

Repurposing with a Difference

2009 • 220 citations

Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)α and ERβ ligand treatment

2007 • 217 citations

Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir

2011 • 169 citations

Treatment with an Estrogen Receptor Ligand Is Neuroprotective in Experimental Autoimmune Encephalomyelitis

2006 • 142 citations

Accurate and diverse recommendations via eliminating redundant correlations

2009 • 128 citations

NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling

2010 • 116 citations

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

2011 • 101 citations

Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics

2009 • 78 citations

MIND-BEST: Web Server for Drugs and Target Discovery; Design, Synthesis, and Assay of MAO-B Inhibitors and Theoretical−Experimental Study of G3PDH Protein fromTrichomonas gallinae

2010 • 69 citations

Inhibitory effect of statins on the proliferation of human breast cancer cells

2004 • 65 citations

Non-Steroidal Subtype Selective Estrogens

2005 • 61 citations

Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism

2006 • 51 citations

Discovery of Potent Ligands for Estrogen Receptor β by Structure-Based Virtual Screening

2010 • 48 citations

The Effect of an Inhaled Corticosteroid on Glucose Control in Type 2 Diabetes

2009 • 47 citations

Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor β agonist and induces GLUT4 expression in CHO-K1 cells

2008 • 21 citations

Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection

2003 • 18 citations

Use of oral ketoconazole to prevent postoperative erections following penile surgery

2004 • 14 citations

Ketoconazole for prevention of postoperative penile erection

1995 • 6 citations