Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements
Data up to Jan 2025
Total Citations Per Year
Abstract
References (51)
TGF-β SIGNAL TRANSDUCTION
1998 • 7,582 citations
How many drug targets are there?
2006 • 3,319 citations
The orphan receptor GPR55 is a novel cannabinoid receptor
2007 • 1,487 citations
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
2003 • 1,469 citations
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
2006 • 1,076 citations
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
2003 • 1,050 citations
The genetic design of signaling cascades to record receptor activation
2007 • 643 citations
Agonist-receptor efficacy II: agonist trafficking of receptor signals
1995 • 637 citations
β-Arrestin-biased ligands at seven-transmembrane receptors
2007 • 577 citations
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
2003 • 497 citations
A Novel Gαq/11-selective Inhibitor
2004 • 383 citations
Resonant Waveguide Grating Biosensor for Living Cell Sensing
2006 • 364 citations
The evasive nature of drug efficacy: implications for drug discovery
2007 • 351 citations
Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent
2010 • 287 citations
Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
2006 • 284 citations
The enigmatic pharmacology of GPR55
2009 • 280 citations
β-arrestins: traffic cops of cell signaling
2004 • 280 citations
The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+signaling and NFAT activation
2008 • 278 citations
Alternative Splicing in the N-terminal Extracellular Domain of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor Modulates Receptor Selectivity and Relative Potencies of PACAP-27 and PACAP-38 in Phospholipase C Activation
1996 • 223 citations
GPR55 ligands promote receptor coupling to multiple signalling pathways
2010 • 195 citations
Receptors coupled to heterotrimeric G proteins of the G12 family
2005 • 175 citations
High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay
2005 • 173 citations
cAMP detection methods in HTS: selecting the best from the rest
2004 • 167 citations
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
2009 • 153 citations
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity
2008 • 147 citations
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox
2003 • 130 citations
Generation of cortical neurons from mouse embryonic stem cells
2009 • 127 citations
Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes
2008 • 122 citations
Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates
2007 • 116 citations
Live-cell imaging of cAMP dynamics
2007 • 105 citations
Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells
2006 • 89 citations
Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with β-Arrestin-1 and -2
2008 • 87 citations
Impedance-based cellular assay technologies: recent advances, future promise
2007 • 79 citations
βGalactosidase Complementation: A Cell-Based Luminescent Assay Platform for Drug Discovery
2007 • 79 citations
Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist
2007 • 79 citations
Oligomerization of Wild Type and Nonfunctional Mutant Angiotensin II Type I Receptors Inhibits Gαq Protein Signaling but Not ERK Activation
2004 • 77 citations
The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1
2009 • 77 citations
Comparing Label-Free Biosensors for Pharmacological Screening With Cell-Based Functional Assays
2010 • 68 citations
Evaluation of Dynamic Mass Redistribution Technology for Pharmacological Studies of Recombinant and Endogenously Expressed G Protein-Coupled Receptors
2008 • 61 citations
Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance
2007 • 60 citations
The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαi and Downstream Signaling Cascade Activation
2008 • 60 citations
A 100K well screen for a muscarinic receptor using the Epic®label-free system – a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors
2009 • 54 citations
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
1995 • 49 citations
Allosteric Small Molecules Unveil a Role of an Extracellular E2/Transmembrane Helix 7 Junction for G Protein-coupled Receptor Activation
2007 • 46 citations
Functional G Protein-Coupled Receptor Assays for Primary and Secondary Screening
2005 • 44 citations
G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors
2008 • 36 citations
7TM pharmacology measured by label-free: a holistic approach to cell signalling
2009 • 36 citations
Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells
2007 • 34 citations
m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis.
1996 • 31 citations
Effects of prostaglandin E1 on human keratinocytes and dermal fibroblasts: A possible mechanism for the healing of skin ulcers
1994 • 28 citations
Enhanced Selectivity Screening of GPCR Ligands Using a Label-Free Cell Based Assay Technology
2009 • 20 citations