Current Management of Small Cell Lung Cancer

Sorafenib in Advanced Hepatocellular Carcinoma

2008 • 11,718 citations

Sorafenib in Advanced Hepatocellular Carcinoma

2008 • 5,675 citations

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

The global burden of disease.

2013 • 4,991 citations

Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma

2007 • 4,669 citations

The resurgence of platinum-based cancer chemotherapy

2007 • 4,340 citations

The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours

2007 • 3,597 citations

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

2008 • 3,092 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy

2004 • 2,376 citations

Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database

2006 • 1,745 citations

Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission

1999 • 1,607 citations

Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide

1999 • 1,394 citations

Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer

2002 • 1,346 citations

A Meta-Analysis of Thoracic Radiotherapy for Small-Cell Lung Cancer

1992 • 1,295 citations

Angiogenesis

2006 • 1,131 citations

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

2009 • 1,089 citations

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

2003 • 1,066 citations

Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer

2007 • 1,015 citations

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

2009 • 987 citations

Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer

1999 • 909 citations

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

2009 • 836 citations

Randomized Phase III Trial Comparing Irinotecan/Cisplatin With Etoposide/Cisplatin in Patients With Previously Untreated Extensive-Stage Disease Small-Cell Lung Cancer

2006 • 654 citations

Phase III Trial Comparing Supportive Care Alone With Supportive Care With Oral Topotecan in Patients With Relapsed Small-Cell Lung Cancer

2006 • 603 citations

Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors

2011 • 542 citations

Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

2008 • 524 citations

Phase III Trial of Irinotecan/Cisplatin Compared With Etoposide/Cisplatin in Extensive-Stage Small-Cell Lung Cancer: Clinical and Pharmacogenomic Results From SWOG S0124

2009 • 507 citations

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

1997 • 474 citations

Systematic Review Evaluating the Timing of Thoracic Radiation Therapy in Combined Modality Therapy for Limited-Stage Small-Cell Lung Cancer

2004 • 376 citations

Phase III Study of Oral Compared With Intravenous Topotecan As Second-Line Therapy in Small-Cell Lung Cancer

2007 • 356 citations

A Prospective Randomized Trial to Determine the Benefit of Surgical Resection of Residual Disease Following Response of Small Cell Lung Cancer to Combination Chemotherapy

1994 • 309 citations

VP-16 and cisplatin as first-line therapy for small-cell lung cancer.

1985 • 301 citations

Tracheoesophageal Fistula Formation in Patients With Lung Cancer Treated With Chemoradiation and Bevacizumab

2009 • 292 citations

Prophylactic Cranial Irradiation in Extensive Disease Small-Cell Lung Cancer: Short-Term Health-Related Quality of Life and Patient Reported Symptoms—Results of an International Phase III Randomized Controlled Trial by the EORTC Radiation Oncology and Lung Cancer Groups

2008 • 247 citations

Randomized Phase II Trial Comparing Amrubicin With Topotecan in Patients With Previously Treated Small-Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 0402

2008 • 236 citations

Phase II Trial of Amrubicin for Treatment of Refractory or Relapsed Small-Cell Lung Cancer: Thoracic Oncology Research Group Study 0301

2006 • 227 citations

Small Cell Lung Cancer: Have We Made Any Progress Over the Last 25 Years?

2007 • 203 citations

Phase III Study of Pemetrexed Plus Carboplatin Compared With Etoposide Plus Carboplatin in Chemotherapy-Naive Patients With Extensive-Stage Small-Cell Lung Cancer

2009 • 195 citations

Randomized Phase III Intergroup Trial of Etoposide and Cisplatin With or Without Paclitaxel and Granulocyte Colony-Stimulating Factor in Patients With Extensive-Stage Small-Cell Lung Cancer: Cancer and Leukemia Group B Trial 9732

2005 • 185 citations

Etoposide Plus Cisplatin With or Without the Combination of 4'-Epidoxorubicin Plus Cyclophosphamide in Treatment of Extensive Small-Cell Lung Cancer: a French Federation of Cancer Institutes Multicenter Phase III Randomized Study

2001 • 171 citations

Randomized Phase II Trial of Single-Agent Amrubicin or Topotecan as Second-Line Treatment in Patients With Small-Cell Lung Cancer Sensitive to First-Line Platinum-Based Chemotherapy

2010 • 171 citations

Long-term results of a phase III trial comparing once-daily radiotherapy with twice-daily radiotherapy in limited-stage small-cell lung cancer

2004 • 167 citations

Phase I Study of G3139, a bcl-2 Antisense Oligonucleotide, Combined With Carboplatin and Etoposide in Patients With Small-Cell Lung Cancer

2004 • 167 citations

Randomized Phase II Study of Carboplatin and Etoposide With or Without thebcl-2Antisense Oligonucleotide Oblimersen for Extensive-Stage Small-Cell Lung Cancer: CALGB 30103

2008 • 164 citations

Pemetrexed (ALIMTA), A Novel Multitargeted Antineoplastic Agent

2004 • 158 citations

Cisplatin plus etoposide with and without ifosfamide in extensive small-cell lung cancer: a Hoosier Oncology Group study.

1995 • 157 citations

Phase II Study of Cisplatin Plus Etoposide and Bevacizumab for Previously Untreated, Extensive-Stage Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Study E3501

2009 • 148 citations

Phase III Double-Blind, Placebo-Controlled Study of Thalidomide in Extensive-Disease Small-Cell Lung Cancer After Response to Chemotherapy: An Intergroup Study FNCLCC cleo04–IFCT 00-01

2007 • 142 citations

Anti-angiogenic Therapy Using Thalidomide Combined With Chemotherapy in Small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial

2009 • 133 citations

The Role of Surgery in the Treatment of Limited Disease Small Cell Lung Cancer: Time to Reevaluate

2008 • 126 citations

Phase II Study of Amrubicin As Second-Line Therapy in Patients With Platinum-Refractory Small-Cell Lung Cancer

2010 • 124 citations

Phase II Trial of Gemcitabine in Refractory or Relapsed Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Trial 1597

2003 • 120 citations

Phase II study of amrubicin in previously untreated patients with extensive-disease small cell lung cancer: West Japan Thoracic Oncology Group (WJTOG) study

2006 • 110 citations

A German multicenter, randomized phase III trial comparing irinotecan–carboplatin with etoposide–carboplatin as first-line therapy for extensive-disease small-cell lung cancer

2011 • 109 citations

A New Antitumor Agent Amrubicin Induces Cell Growth Inhibition by Stabilizing Topoisomerase II‐DNA Complex

1998 • 107 citations

Phase II Study of Picoplatin As Second-Line Therapy for Patients With Small-Cell Lung Cancer

2009 • 85 citations

A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy

1994 • 85 citations

Phase II Trial of Irinotecan, Carboplatin, and Bevacizumab in the Treatment of Patients with Extensive-Stage Small-Cell Lung Cancer

2009 • 85 citations

Randomized Phase II Trial of Pemetrexed Combined With Either Cisplatin or Carboplatin in Untreated Extensive-Stage Small-Cell Lung Cancer

2006 • 81 citations

Limited-Stage Small Cell Lung Cancer: Current Chemoradiotherapy Treatment Paradigms

2010 • 81 citations

Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs

1998 • 72 citations

Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung

2009 • 71 citations

Update on paraneoplastic syndromes

2005 • 68 citations

Single-agent gemcitabine in patients with resistant small-cell lung cancer

2001 • 65 citations

Comparison of gemcitabine and carboplatin versus cisplatin and etoposide for patients with poor-prognosis small cell lung cancer

2008 • 61 citations

Inhibition of Insulin-Like Growth Factor 1 Receptor by CP-751,871 Radiosensitizes Non–Small Cell Lung Cancer Cells

2009 • 59 citations

Sorafenib in Platinum-Treated Patients with Extensive Stage Small Cell Lung Cancer: A Southwest Oncology Group (SWOG 0435) Phase II Trial

2010 • 58 citations

Reduction in BCL-2 levels by 26S proteasome inhibition with bortezomib is associated with induction of apoptosis in small cell lung cancer

2005 • 54 citations

Randomized phase III trial of amrubicin versus topotecan (Topo) as second-line treatment for small cell lung cancer (SCLC).

2011 • 51 citations

Small Cell Lung Cancer: Are We Making Progress?

2009 • 51 citations

CALGB 30306: A phase II study of cisplatin (C), irinotecan (I) and bevacizumab (B) for untreated extensive stage small cell lung cancer (ES-SCLC)

2007 • 50 citations

A Phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473)

2003 • 43 citations

Randomized phase III study (SPEAR) of picoplatin plus best supportive care (BSC) or BSC alone in patients (pts) with SCLC refractory or progressive within 6 months after first-line platinum-based chemotherapy.

2010 • 42 citations

A phase II study of amrubicin combined with carboplatin for elderly patients with small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0405

2009 • 37 citations

Phase II trial of thalidomide with chemotherapy and as maintenance therapy for patients with poor prognosis small-cell lung cancer

2007 • 35 citations

ZD0473 treatment in lung cancer: an overview of the clinical trial results

2002 • 32 citations

Phase II trial of thalidomide as maintenance therapy for extensive stage small cell lung cancer after response to chemotherapy

2007 • 31 citations

Pemetrexed in Relapsed Small-Cell Lung Cancer and the Impact of Shortened Vitamin Supplementation Lead-In Time: Results of a Phase II Trial

2008 • 28 citations

Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity of lung cancer cell lines by blocking IGF-1 pathway

2006 • 26 citations

Phase I and pharmacokinetic study of SM-5887, a new anthracycline derivative

1989 • 24 citations

Amrubicin for the Treatment of Small Cell Lung Cancer: Does Effectiveness Cross the Pacific?

2007 • 22 citations

Phase II study of RAD001 (everolimus) in previously treated small cell lung cancer (SCLC)

2009 • 19 citations

A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensive-disease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401

2011 • 18 citations

Phase II study of RAD001 (Everolimus) in previously treated small cell lung cancer (SCLC)

2008 • 18 citations

Phase II trial of amrubicin and carboplatin in patients with sensitive or refractory relapsed small-cell lung cancer

2011 • 12 citations

Phase II Study of Sequential Triplet Chemotherapy, Irinotecan and Cisplatin Followed by Amrubicin, in Patients with Extensive-Stage Small Cell Lung Cancer: West Japan Thoracic Oncology Group Study 0301

2010 • 11 citations