G protein signaling and the molecular basis of antidepressant action

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

The Corticosteroid Receptor Hypothesis of Depression

2000 • 2,126 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

1997 • 1,080 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

1995 • 612 citations

Neuronal Cyclic AMP Controls the Developmental Loss in Ability of Axons to Regenerate

2001 • 527 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment

2000 • 503 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein

2002 • 478 citations

Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex

1988 • 474 citations

Lipid-dependent Targeting of G Proteins into Rafts

2000 • 428 citations

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

2001 • 370 citations

Membrane organization in G‐protein mechanisms

1994 • 345 citations

cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs

2002 • 330 citations

Signal Transduction Pathways

1995 • 328 citations

Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex

2002 • 316 citations

Organization of G Proteins and Adenylyl Cyclase at the Plasma Membrane

1997 • 211 citations

Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1.

1990 • 204 citations

Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiesterase 4A and 4B Isoforms

1999 • 175 citations

Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration

2002 • 171 citations

A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.

1997 • 148 citations

Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment

1983 • 142 citations

Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims

1994 • 136 citations

Effects of colchicine on cyclic AMP levels in human leukocytes

1977 • 132 citations

Neurobiology of lithium: an update.

1998 • 130 citations

The regulatory subunit of adenylate cyclase interacts with cytoskeletal components

1981 • 129 citations

Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.

1980 • 118 citations

Real-Time Visualization of a Fluorescent Gα_s: Dissociation of the Activated G Protein from Plasma Membrane

2002 • 113 citations

Chronic Electroconvulsive Treatment Augments Coupling of the GTP‐Binding Protein G_s to the Catalytic Moiety of Adenylyl Cyclase in a Manner Similar to That Seen with Chronic Antidepressant Drugs

1991 • 110 citations

Antipsychotics in bipolar disorder.

1996 • 108 citations

Tubulin-G protein interactions involve microtubule polymerization domains

1991 • 102 citations

cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment

1989 • 102 citations

G protein binding and G protein activation by nucleotide transfer involve distinct domains on tubulin: Regulation of signal transduction by cytoskeletal elements

1993 • 97 citations

Lithium regulates PKC‐mediated intracellular cross‐talk and gene expression in the CNS in vivo

2000 • 92 citations

Fluoxetine increases the content of neurotrophic protein S100β in the rat hippocampus

2001 • 91 citations

Tubulin, Gq, and Phosphatidylinositol 4,5-Bisphosphate Interact to Regulate Phospholipase Cβ1 Signaling

1997 • 90 citations

Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase is enhanced subsequent to chronic antidepressant treatment.

1989 • 81 citations

Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism‐induced defects in memory function and cerebral cyclic AMP signal transduction system in rats

2002 • 79 citations

Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription.

1995 • 79 citations

Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content.

1995 • 78 citations

Exchange of Guanine Nucleotides Between Tubulin and GTP‐Binding Proteins That Regulate Adenylate Cyclase: Cytoskeletal Modification of Neuronal Signal Transduction

1988 • 76 citations

Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor

2000 • 75 citations

cAMP binding proteins in the rat cerebral cortex after administration of selective 5-HT and NE reuptake blockers with antidepressant activity.

1991 • 72 citations

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein (G_S) and Adenylyl Cyclase

1995 • 70 citations

Desensitization of β‐Adrenergic Receptor‐Coupled Adenylate Cyclase in Cerebral Cortex After In Vivo Treatment of Rats with Desipramine

1986 • 62 citations

Regulation of G proteins by chronic antidepressant drug treatment in rat brain: tricyclics but not clorgyline increase Goα subunits

1991 • 62 citations

Effect of imipramine and adrenocorticotropin administration on the rat brain norepinephrine-coupled cyclic nucleotide generating system: alterations in alpha and beta adrenergic components.

1985 • 61 citations

Colchicine potentiates β-adrenoreceptor-stimulated cyclic AMP in lymphoma cells by an action distal to the receptor

1978 • 60 citations

Effect of the Tricyclic Antidepressant Desipramine on β‐Adrenergic Receptors in Cultured Rat Glioma C6 Cells

1987 • 54 citations

Treatment of C6 Glioma Cells and Rats with Antidepressant Drugs Increases the Detergent Extraction of G_sα from Plasma Membrane

1999 • 53 citations

Pharmacological actions of the antidepressant venlafaxine beyond aminergic receptors

1999 • 52 citations

Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number of beta-adrenoceptors

1986 • 49 citations

Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.

1981 • 48 citations

Exchange of guanine nucleotide between GTP-binding proteins that regulate neuronal adenylate cyclase.

1986 • 47 citations

Alterations in Detergent Solubility of Heterotrimeric G Proteins after Chronic Activation of G_i/o-Coupled Receptors: Changes in Detergent Solubility Are in Correlation with Onset of Adenylyl Cyclase Superactivation

2000 • 45 citations

Inhibitors of microtubule assembly enhance beta-adrenergic and prostaglandin E1-stimulated cyclic AMP accumulation in S49 lymphoma cells.

1979 • 43 citations

Cyclic Nucleotide-Mediated Regulation of Hippocampal Mossy Fiber Development: A Target-Specific Guidance

2001 • 43 citations

Muscarinic Receptor Activation Promotes the Membrane Association of Tubulin for the Regulation of Gq-Mediated Phospholipase Cβ₁Signaling

2000 • 42 citations

Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?

2002 • 41 citations

Synaptic Membrane G Proteins Are Complexed with Tubulin In Situ

1996 • 40 citations

Antidepressant interactions with corticotropin-releasing factor in the noradrenergic nucleus locus coeruleus.

1991 • 39 citations

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gsα

2001 • 37 citations

Antidepressant treatments and regulation of norepinephrine-receptor-coupled adenylate cyclase systems in brain.

1984 • 37 citations

Interaction of Antibipolar and Antidepressant Treatments with Receptor-Coupled G Proteins

1992 • 36 citations

Limited trypsin proteolysis of photoreceptor GTP-binding protein. Light- and GTP-induced conformational changes.

1984 • 35 citations

Corticotropin-releasing factor antagonists in affective disorders

1999 • 35 citations

Agonist interactions with beta adrenergic receptors in rat brain.

1984 • 34 citations

Acute and chronic effects of antidepressant drugs on β‐adrenergic function in astrocytes in primary cultures: An indication of glial involvement in affective disorders?

1983 • 34 citations

The interaction of colchicine with hormone-sensitive adenylate cyclase in human leukocytes.

1979 • 30 citations

Lithium Modulation of Phosphoinositide Signaling System in Rat Cortex: Selective Effect on Phorbol Ester Binding

1993 • 29 citations

Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders

2001 • 29 citations

Close reciprocal regulation of beta 1- and beta 2-adrenergic receptors by dexamethasone in C6 glioma cells: effects on catecholamine responsiveness.

1993 • 29 citations

Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells

1994 • 28 citations

Selective adenylate cyclase increase in the limbic area of long-term imipramine-treated rats

1990 • 27 citations

[8] Photoaffinity guanosine 5′-triphosphate analogs as a tool for the study of GTP-binding proteins

1994 • 23 citations

Effects of subchronic administration of antidepressants and anxiolytics on levels of the ? subunits of G proteins in the rat brain

1997 • 23 citations

Fluoride-stimulated adenylate cyclase activity in rat brain following chronic treatment with psychotropic drugs

1984 • 22 citations

Lack of Effect of Chronic Antidepressant Treatment on Gs and Gi α-Subunit Protein and mRNA Levels in the Rat Cerebral Cortex

1996 • 20 citations

In situ binding of a photo‐affinity GTP analog to synaptic membrane G‐proteins Distribution of bound GTP analog reflects the status of adenylate cyclase

1988 • 20 citations

Differential effects of chronic administration of desipramine on the cyclic AMP response in cortical slices and membranes in the rat

1987 • 17 citations

Reduction in β‐Adrenoceptor Density in Cultured Rat Glioma C6 Cells After Incubation with Antidepressants Is Dependent upon the Culturing Conditions Used

1990 • 15 citations

Alterations of tubulin function caused by chronic antidepressant treatment in rat brain.

1999 • 14 citations

Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein

1995 • 14 citations

Chronic exposure of C6 glioma cells to desipramine desensitizes ß-adrenoceptors, but increases ratio

1991 • 13 citations

Models of antidepressant action.

1999 • 13 citations

Antidepressants directly influence in situ binding of guanine nucleotide in synaptic membrane

1994 • 12 citations

The effect of chronic treatment with imipramine on the G proteins mRNA level in the rat hippocampus--an interaction with a calcium channel antagonist.

1993 • 11 citations

A cyclic AMP-regulated negative feedforward system for neuritogenesis revealed in a neuroblastoma×glioma hybrid cell line

2001 • 11 citations

The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline.

1992 • 9 citations

Idazoxan down-regulates β-adrenoceptors on C6 glioma cells in vitro

1992 • 6 citations