The suicidal DNA repalr methyltransferases of microbes

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

A structural taxonomy of DNA-binding domains

1991 • 615 citations

Improved detection of helix-turn-helix DNA-binding motifs in protein sequences

1990 • 526 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Adaptive response of escherichia coli to alkylation damage

1988 • 108 citations

Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.

1986 • 108 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.

1991 • 101 citations

Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

1991 • 94 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

Purification of theE.coliogt gene product to homogeneity and its rate of action onO⁶-methylguanine,O⁶-ethyiguanine andO⁴-methylthymine in dodecadeoxyribnucleotides

1989 • 81 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

1990 • 68 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

Functional sites of the Ada regulatory protein of Escherichia coli

1988 • 59 citations

Resistance to alkylation damage in Escherichia coli: Role of the Ada protein in induction of the adaptive response

1990 • 51 citations

Bacillus subtilis adaoperon encodes two DNA alkyltransferases

1990 • 51 citations

Regulation of expression of the ada gene controlling the adaptive response

1989 • 51 citations

Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase

1991 • 48 citations

Positive and negative regulation of transcription by a cleavage product of Ada protein

1990 • 45 citations

Widespread adaptive response against environmental methylating agents in microorganisms

1991 • 44 citations

In vitro proteolytic cleavage of the Escherichia coli Ada protein by the ompT gene product

1989 • 44 citations

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli

1991 • 43 citations

Expression of the ada gene of Escherichia coli in response to alkylating agents

1988 • 41 citations

Bacillus subtilisgene coding for constitutiveO⁶-methylguanine-DNA alkyttransferase

1989 • 37 citations

A weak adaptive response to alkylation damage in Salmonella typhimurium

1991 • 29 citations

Inducible alkyltransferase DNA repair proteins in the filamentous fungusAspergillus nidulans

1992 • 27 citations

S-Adenosylmethionine, an endogenous alkylating agent

1983 • 24 citations

Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada− cells

1989 • 24 citations

Adaptive response orMicrococcus luteusto alkylating chemlcals

1984 • 23 citations

A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkA.

1991 • 22 citations

Polyclonal antibodies against O6-methylguanine-DNA methyltransferase in adapted bacteria

1988 • 19 citations

An adaptive response to alkylating agents in Aspergillus nidulans

1988 • 11 citations

A constitutive O6-methylguanine-DNA methyltransferase of Rhizobium meliloti

1990 • 7 citations

O⁶-methylguanine in the SV40 origin of replication inhibits binding but increases unwinding by viral large T antigen

1990 • 6 citations

Methyl transferases induced during chemical adaptation ofM. luteus

1987 • 5 citations