Functional sites of the Ada regulatory protein of Escherichia coli

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid

1978 • 4,472 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

[57] Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria

1975 • 839 citations

Construction and characterization of the chloramphenicol-resistance gene cartridge: A new approach to the transcriptional mapping of extrachromosomal elements

1982 • 307 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Location of DNA methylation genes on the Escherichia coli K-12 genetic map

1973 • 211 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

[5] Kilo-sequencing: Creation of an ordered nest of asymmetric deletions across a large target sequence carried on phage M13

1983 • 169 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Cloning of theE. coliO⁶-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay

1985 • 124 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II.

1984 • 90 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

Enzymic excision of 3-methyladenine and 7-methylguanine by a rat liver nuclear fraction

1981 • 58 citations

Adaptive response: induced synthesis of DNA repair enzymes by alkylating agents

1987 • 56 citations

Pathways for repair of DNA damaged by alkylating agent in Escherichia coli

1979 • 44 citations

Expression of the E. coli O⁶-methylguanine-methylphosphotriester methyltransferase gene in mammalian cells

1986 • 31 citations

MutantEscherichia coliAda proteins simultaneously defective in the repair of O⁶-metbylguanine and in gene activation

1986 • 28 citations